Open Access

Paclitaxel plus nedaplatin vs. paclitaxel plus carboplatin in women with epithelial ovarian cancer: A multi-center, randomized, open-label, phase III trial

  • Authors:
    • Li Li
    • Qingqing Zhuang
    • Zeyi Cao
    • Rutie Yin
    • Yaping Zhu
    • Lirong Zhu
    • Xing Xie
    • Youzhong Zhang
    • Qiang Wu
    • Jianhua Zheng
    • Qi Zhou
    • Xiaoping Li
    • Lingying Wu
    • Youji Feng
    • Changyu Wang
  • View Affiliations

  • Published online on: January 10, 2018     https://doi.org/10.3892/ol.2018.7761
  • Pages: 3646-3652
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The multi-center, randomized, open-label, phase III trial discussed in the present study was performed to compare the clinical outcomes of nedaplatin (NDP) plus paclitaxel, and carboplatin (CBP) plus paclitaxel for the treatment of epithelial ovarian cancer (EOC). In the current study, 182 patients with International Federation of Gynecology and Obstetrics (FIGO) stage II‑IV EOC were randomly assigned to receive NDP plus paclitaxel or CBP plus paclitaxel at 3‑week intervals for a total of six courses. The primary endpoints were progression‑free survival rate (PFS) and overall survival rate (OS). The secondary endpoints were toxicity profiles. The median follow‑up was 44.63 months [95% confidence interval (CI) 33.67‑46.47 months] for the NDP group and 47.63 months (95% CI 45.13‑49.07 months) for the CBP group. Overall, there was no significant difference in PFS or OS between the two groups (P=0.09 for PFS, and P=0.65 for OS). For the patients with FIGO stage III‑IV EOC, the NDP plus paclitaxel regimen significantly prolonged PFS (P=0.02) but did not result in improved OS (P=0.53) when compared with the CBP group. The patients in the NDP plus paclitaxel group also exhibited a lower incidence rate of grade 3 or 4 leucopenia (P=0.03). Other hematological and non-hematological toxicity profiles were similar between the two groups. Compared with CBP plus paclitaxel regimens, NDP plus paclitaxel regimens achieved comparable survival outcomes and similar toxicity profiles. However, patients of FIGO stage III‑IV EOC may experience more clinical benefits from NDP plus paclitaxel treatment, including a prolonged PFS and a lower incidence rate of leucopenia. Therefore, an NDP‑based regimen may be an alternative choice when using platinum‑based agents to treat EOC.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li L, Zhuang Q, Cao Z, Yin R, Zhu Y, Zhu L, Xie X, Zhang Y, Wu Q, Zheng J, Zheng J, et al: Paclitaxel plus nedaplatin vs. paclitaxel plus carboplatin in women with epithelial ovarian cancer: A multi-center, randomized, open-label, phase III trial. Oncol Lett 15: 3646-3652, 2018
APA
Li, L., Zhuang, Q., Cao, Z., Yin, R., Zhu, Y., Zhu, L. ... Wang, C. (2018). Paclitaxel plus nedaplatin vs. paclitaxel plus carboplatin in women with epithelial ovarian cancer: A multi-center, randomized, open-label, phase III trial. Oncology Letters, 15, 3646-3652. https://doi.org/10.3892/ol.2018.7761
MLA
Li, L., Zhuang, Q., Cao, Z., Yin, R., Zhu, Y., Zhu, L., Xie, X., Zhang, Y., Wu, Q., Zheng, J., Zhou, Q., Li, X., Wu, L., Feng, Y., Wang, C."Paclitaxel plus nedaplatin vs. paclitaxel plus carboplatin in women with epithelial ovarian cancer: A multi-center, randomized, open-label, phase III trial". Oncology Letters 15.3 (2018): 3646-3652.
Chicago
Li, L., Zhuang, Q., Cao, Z., Yin, R., Zhu, Y., Zhu, L., Xie, X., Zhang, Y., Wu, Q., Zheng, J., Zhou, Q., Li, X., Wu, L., Feng, Y., Wang, C."Paclitaxel plus nedaplatin vs. paclitaxel plus carboplatin in women with epithelial ovarian cancer: A multi-center, randomized, open-label, phase III trial". Oncology Letters 15, no. 3 (2018): 3646-3652. https://doi.org/10.3892/ol.2018.7761