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Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia

  • Authors:
    • Kei Kushitani
    • Vishwa Jeet Amatya
    • Amany Sayed Mawas
    • Rui Suzuki
    • Yoshihiro Miyata
    • Morihito Okada
    • Kouki Inai
    • Takumi Kishimoto
    • Yukio Takeshima
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8551, Japan, Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt, Department of Surgical Oncology, Research Center for Radiation Casualty Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734‑8551, Japan, Department of Internal Medicine, Okayama Rosai Hospital, Okayama 702‑8055, Japan
    Copyright: © Kushitani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3540-3547
    |
    Published online on: January 10, 2018
       https://doi.org/10.3892/ol.2018.7765
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Abstract

Histological distinction between epithelioid mesothelioma (EM) and reactive mesothelial hyperplasia (RMH) can be challenging. The aim of this study was to assess the diagnostic utility of Survivin, Ki‑67, and loss of BRCA1‑associated protein 1 (BAP1) expressions in distinguishing EM from RMH using immunohistochemistry. Formalin‑fixed, paraffin‑embedded specimens from 78 cases of EM and 80 cases of RMH were immunohistochemically examined for Survivin, BAP1, and Ki‑67. In addition, receiver operating characteristic curve analyses were performed to establish the cut‑off values for Survivin and Ki‑67 labelling indices. Survivin (cut‑off value: 5%) had 67.7% sensitivity and 100% specificity, while Ki‑67 (cut‑off value: 10%) had 85.1% sensitivity and 87.5% specificity, and BAP1 had 66.2% sensitivity and 100% specificity for the differentiation of EM from RMH. Among the combinations of two markers, the combination of Survivin and BAP1 (Survivin‑positive and/or BAP1‑loss finding) had the highest diagnostic accuracy (sensitivity: 89.8%; specificity: 100%; accuracy: 95.3%). We recommend using the combination of Survivin and BAP1 to distinguish EM from RMH.
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Copy and paste a formatted citation
Spandidos Publications style
Kushitani K, Amatya VJ, Mawas AS, Suzuki R, Miyata Y, Okada M, Inai K, Kishimoto T and Takeshima Y: Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia. Oncol Lett 15: 3540-3547, 2018.
APA
Kushitani, K., Amatya, V.J., Mawas, A.S., Suzuki, R., Miyata, Y., Okada, M. ... Takeshima, Y. (2018). Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia. Oncology Letters, 15, 3540-3547. https://doi.org/10.3892/ol.2018.7765
MLA
Kushitani, K., Amatya, V. J., Mawas, A. S., Suzuki, R., Miyata, Y., Okada, M., Inai, K., Kishimoto, T., Takeshima, Y."Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia". Oncology Letters 15.3 (2018): 3540-3547.
Chicago
Kushitani, K., Amatya, V. J., Mawas, A. S., Suzuki, R., Miyata, Y., Okada, M., Inai, K., Kishimoto, T., Takeshima, Y."Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia". Oncology Letters 15, no. 3 (2018): 3540-3547. https://doi.org/10.3892/ol.2018.7765
Copy and paste a formatted citation
x
Spandidos Publications style
Kushitani K, Amatya VJ, Mawas AS, Suzuki R, Miyata Y, Okada M, Inai K, Kishimoto T and Takeshima Y: Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia. Oncol Lett 15: 3540-3547, 2018.
APA
Kushitani, K., Amatya, V.J., Mawas, A.S., Suzuki, R., Miyata, Y., Okada, M. ... Takeshima, Y. (2018). Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia. Oncology Letters, 15, 3540-3547. https://doi.org/10.3892/ol.2018.7765
MLA
Kushitani, K., Amatya, V. J., Mawas, A. S., Suzuki, R., Miyata, Y., Okada, M., Inai, K., Kishimoto, T., Takeshima, Y."Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia". Oncology Letters 15.3 (2018): 3540-3547.
Chicago
Kushitani, K., Amatya, V. J., Mawas, A. S., Suzuki, R., Miyata, Y., Okada, M., Inai, K., Kishimoto, T., Takeshima, Y."Utility of Survivin, BAP1, and Ki‑67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia". Oncology Letters 15, no. 3 (2018): 3540-3547. https://doi.org/10.3892/ol.2018.7765
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