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Article

Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility

  • Authors:
    • Masafumi Ota
    • Tomomitsu Tahara
    • Toshimi Otsuka
    • Wu Jing
    • Tomoe Nomura
    • Ranji Hayashi
    • Takeo Shimasaki
    • Masakatsu Nakamura
    • Tomoyuki Shibata
    • Tomiyasu Arisawa
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Kanazawa Medical University, Uchinada‑machi, Ishikawa 920‑0293, Japan, Department of Gastroenterology, Fujita Health University, Toyoake, Aichi 470‑1192, Japan
  • Pages: 3772-3778
    |
    Published online on: January 12, 2018
       https://doi.org/10.3892/ol.2018.7785
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Abstract

The present study aimed to investigate whether single nucleotide polymorphisms in receptor interacting serine/threonine kinase 2 (RIPK2), which encodes a component of the nucleotide binding oligomerization domain containing 2‑RIP2 pathway, may compromise the innate immune response to Helicobacter pylori infection, leading to increased susceptibility to gastric cancer in the Japanese population. The present case control study investigated the associations between RIPK2 single nucleotide polymorphisms and gastric mucosal inflammation, atrophy and cancer susceptibility in 528 patients with gastric cancer and 697 patients without gastric malignancies on upper gastro‑duodenal endoscopy. Overall, the RIPK2 rs16900627 minor allele was significantly associated with the susceptibility to gastric cancer [OR, 1.37; 95% confidence interval (CI), 1.06‑1.77; P=0.016], particularly of the intestinal type (OR, 1.53; 95% CI, 1.13‑2.07; P=0.0062). It was also significantly associated with gastric mucosal atrophy (OR, 1.83; 95% CI, 1.14‑2.93; P=0.011). When assessing the severity of chronic gastritis using the updated Sydney system, the activity and inflammation scores, as well as atrophy and metaplasia scores, were significantly higher in rs16900627 minor allele carriers compared with wild‑type homozygotes. In patients younger than 60 years old, the pepsinogen I/II ratio was significantly lower in rs16900627 minor allele carriers compared with wild‑type homozygotes (P=0.037). The rs16900627 minor allele is associated with the severity of gastric mucosal inflammation and the development of gastric mucosal atrophy. Carriers of this allele may have an increased risk for the development of gastric cancer, particularly of the intestinal type.
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1 

Blaser MJ and Parsonnet J: Parasitism by the ‘slow’ bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest. 94:4–8. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Huang JQ, Sridhar S, Chen Y and Hunt RH: Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 114:1169–1179. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N and Schlemper RJ: Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345:784–789. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Correa P: Human gastric carcinogenesis: A multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 52:6735–6740. 1992.PubMed/NCBI

5 

Crabtree JE: Gastric mucosal inflammatory responses to Helicobacter pylori. Aliment Pharmacol Ther. 10 Suppl 1:S29–S37. 1996. View Article : Google Scholar

6 

Rosenstiel P, Hellmig S, Hampe J, Ott S, Till A, Fischbach W, Sahly H, Lucius R, Fölsch UR, Philpott D and Schreiber S: Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection. Cell Microbiol. 8:1188–1198. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Tigno-Aranjuez JT and Abbott DW: Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease. Biochim Biophys Acta. 1823:2022–2028. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kim DJ, Park JH, Franchi L, Backert S and Núñez G: The Cag pathogenicity island and cooperative interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori-infected dendritic cells. Eur J Immunol. 43:2650–2658. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S and Nunez G: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 276:4812–4818. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Li ZX, Wang YM, Tang FB, Zhang L, Zhang Y, Ma JL, Zhou T, You WC and Pan KF: NOD1 and NOD2 genetic variants in association with risk of gastric cancer and its precursors in a Chinese population. PLoS One. 10:e01249492015. View Article : Google Scholar : PubMed/NCBI

11 

Li J, Tian J, Ma Y, Cen H, Leng RX, Lu MM, Chen GM, Feng CC, Tao JH, Pan HF and Ye DQ: Association of RIP2 gene polymorphisms and systemic lupus erythematosus in a Chinese population. Mutagenesis. 27:319–322. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Nakashima K, Hirota T, Suzuki Y, Akahoshi M, Shimizu M, Jodo A, Doi S, Fujita K, Ebisawa M, Yoshihara S, et al: Association of the RIP2 gene with childhood atopic asthma. Allergol Int. 55:77–83. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Liu J, He C, Xu Q, Xing C and Yuan Y: NOD2 polymorphisms associated with cancer risk: A meta-analysis. PLoS One. 9:e893402014. View Article : Google Scholar : PubMed/NCBI

14 

Castaño-Rodríguez N, Kaakoush NO, Goh KL, Fock KM and Mitchell HM: The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: A case-control study and meta-analysis. PLoS One. 8:e603272013. View Article : Google Scholar : PubMed/NCBI

15 

Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965. View Article : Google Scholar : PubMed/NCBI

16 

Dixon MF, Genta RM, Yardley JH and Correa P: Classification and grading of gastritis. The updated sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 20:1161–1181. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM and Sirotkin K: dbSNP: The NCBI database of genetic variation. Nucleic Acids Res. 29:308–311. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Arisawa T, Tahara T, Ozaki K, Matsue Y, Minato T, Yamada H, Nomura T, Hayashi R, Matsunaga K, Fukumura A, et al: Association between common genetic variant of HRH2 and gastric cancer risk. Int J Oncol. 41:497–503. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Algood HM and Cover TL: Helicobacter pylori persistence: An overview of interactions between H. pylori and host immune defenses. Clin Microbiol Rev. 19:597–613. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Rad R, Ballhorn W, Voland P, Eisenächer K, Mages J, Rad L, Ferstl R, Lang R, Wagner H, Schmid RM, et al: Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology. 136:2247–2257. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M, Hirata I and Nakano H: Toll-like receptor 2 −196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci. 98:1790–1794. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rigoli L, Di Bella C, Fedele F, Procopio V, Amorini M, Lo Giudice G, Romeo P, Pugliatti F, Finocchiaro G, Lucianò R and Caruso RA: TLR4 and NOD2/CARD15 genetic polymorphisms and their possible role in gastric carcinogenesis. Anticancer Res. 30:513–517. 2010.PubMed/NCBI

23 

Hnatyszyn A, Szalata M, Stanczyk J, Cichy W and Slomski R: Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients. Exp Mol Pathol. 88:388–393. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A and Strober W: NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest. 120:1645–1662. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Marcinek P, Jha AN, Shinde V, Sundaramoorthy A, Rajkumar R, Suryadevara NC, Neela SK, van Tong H, Balachander V, Valluri VL, et al: LRRK2 and RIPK2 variants in the NOD 2-mediated signaling pathway are associated with susceptibility to Mycobacterium leprae in Indian populations. PLoS One. 8:e731032013. View Article : Google Scholar : PubMed/NCBI

26 

Huang YK, Yu JC, Kang WM, Ma ZQ, Ye X, Tian SB and Yan C: Significance of serum pepsinogens as a biomarker for gastric cancer and atrophic gastritis screening: A systematic review and meta-analysis. PLoS One. 10:e01420802015. View Article : Google Scholar : PubMed/NCBI

27 

Lee JY, Kim N, Lee HS, Oh JC, Kwon YH, Choi YJ, Yoon KC, Hwang JJ, Lee HJ, Lee A, et al: Correlations among endoscopic, histologic and serologic diagnoses for the assessment of atrophic gastritis. J Cancer Prev. 19:47–55. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Go MF: Review article: Natural history and epidemiology of Helicobacter pylori infection. Aliment Pharmacol Ther. 16 Suppl 1:S3–S15. 2002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ota M, Tahara T, Otsuka T, Jing W, Nomura T, Hayashi R, Shimasaki T, Nakamura M, Shibata T, Arisawa T, Arisawa T, et al: Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility. Oncol Lett 15: 3772-3778, 2018.
APA
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R. ... Arisawa, T. (2018). Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility. Oncology Letters, 15, 3772-3778. https://doi.org/10.3892/ol.2018.7785
MLA
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R., Shimasaki, T., Nakamura, M., Shibata, T., Arisawa, T."Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility". Oncology Letters 15.3 (2018): 3772-3778.
Chicago
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R., Shimasaki, T., Nakamura, M., Shibata, T., Arisawa, T."Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility". Oncology Letters 15, no. 3 (2018): 3772-3778. https://doi.org/10.3892/ol.2018.7785
Copy and paste a formatted citation
x
Spandidos Publications style
Ota M, Tahara T, Otsuka T, Jing W, Nomura T, Hayashi R, Shimasaki T, Nakamura M, Shibata T, Arisawa T, Arisawa T, et al: Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility. Oncol Lett 15: 3772-3778, 2018.
APA
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R. ... Arisawa, T. (2018). Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility. Oncology Letters, 15, 3772-3778. https://doi.org/10.3892/ol.2018.7785
MLA
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R., Shimasaki, T., Nakamura, M., Shibata, T., Arisawa, T."Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility". Oncology Letters 15.3 (2018): 3772-3778.
Chicago
Ota, M., Tahara, T., Otsuka, T., Jing, W., Nomura, T., Hayashi, R., Shimasaki, T., Nakamura, M., Shibata, T., Arisawa, T."Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility". Oncology Letters 15, no. 3 (2018): 3772-3778. https://doi.org/10.3892/ol.2018.7785
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