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Article

Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.

  • Authors:
    • Xiu‑Mei Li
    • Xue‑Gang Luo
    • Jun‑Fang He
    • Nan Wang
    • Hao Zhou
    • Pei‑Long Yang
    • Tong‑Cun Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Feed Biotechnology of The Ministry of Agriculture, National Engineering Research Center of Biological Feed, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China, Key Laboratory of Industrial Fermentation Microbiology of The Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, Hebei 300457, P.R. China
  • Pages: 3944-3950
    |
    Published online on: January 16, 2018
       https://doi.org/10.3892/ol.2018.7812
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Abstract

Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer activity compounds from H. ascyron L. and the underlying molecular mechanism. Anticancer activity of H. ascyron L. extract was evaluated using an MTT assay. To confirm the anticancer mechanism of activity compounds, Hoechst 33258, Annexin V‑fluorescein isothiocyanate/propidium iodide, 2',7'‑dichlorodihydrofluorescein diacetate, rhodamine 123 staining and caspase‑3 activity analysis were performed. The results demonstrated that the anti‑proliferative action of the mixture of kaempferol 3‑O‑β‑(2
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Copy and paste a formatted citation
Spandidos Publications style
Li XM, Luo XG, He JF, Wang N, Zhou H, Yang PL and Zhang TC: Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncol Lett 15: 3944-3950, 2018.
APA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., & Zhang, T. (2018). Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncology Letters, 15, 3944-3950. https://doi.org/10.3892/ol.2018.7812
MLA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15.3 (2018): 3944-3950.
Chicago
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15, no. 3 (2018): 3944-3950. https://doi.org/10.3892/ol.2018.7812
Copy and paste a formatted citation
x
Spandidos Publications style
Li XM, Luo XG, He JF, Wang N, Zhou H, Yang PL and Zhang TC: Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncol Lett 15: 3944-3950, 2018.
APA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., & Zhang, T. (2018). Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.. Oncology Letters, 15, 3944-3950. https://doi.org/10.3892/ol.2018.7812
MLA
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15.3 (2018): 3944-3950.
Chicago
Li, X., Luo, X., He, J., Wang, N., Zhou, H., Yang, P., Zhang, T."Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.". Oncology Letters 15, no. 3 (2018): 3944-3950. https://doi.org/10.3892/ol.2018.7812
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