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Article

Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration

  • Authors:
    • Dexiao Huang
    • Yong Chen
    • Qingle Zeng
    • Jianbo Zhao
    • Xizhong Wu
    • Renhua Wu
    • Yanhao Li
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong 515041, P.R. China, Department of Interventional Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 3383-3389
    |
    Published online on: December 21, 2017
       https://doi.org/10.3892/ol.2018.7844
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Abstract

Pedunculated hepatocellular carcinoma (P-HCC) is a rare type of HCC, defined as a carcinoma protruding from the liver with or without a pedicle with a low degree of liver invasion. The present study aimed to evaluate the characteristics of blood supply of P-HCC prior to and following transcatheter arterial chemoembolization (TACE) treatment. Angiographic findings prior to and following TACE treatment in 39 patients with P-HCC were analyzed retrospectively. Angiography performed at the first TACE session revealed 70 tumor-feeding arteries collectively in all patients, including 31/70 (44.0%) extrahepatic parasitic arteries in 23/39 patients (59.0%). The intrahepatic arteries served as the main blood supply to P‑HCC in all patients. Extrahepatic collateral blood supplies to P‑HCCs were significantly associated with larger tumor diameter (χ2=164.000, P<0.001), but not tumor location (χ2=7.358, P=0.061). Following repeated TACE treatment, all angiographies revealed a total of 131 tumor feeding arteries collectively in all patients, including intrahepatic arteries (54/131) and extrahepatic collateral arteries (78/131) in 31 patients (79.5%). Compared with angiographies performed at the initial TACE treatment, these results also demonstrated an increase in the number of extrahepatic collateral arteries, which produced 47 new blood vessels (χ2=4.278, P=0.039). P-HCC tumor lesions readily acquired a parasitic blood supply from adjacent vessels following repeated TACE. Intrahepatic arteries functioned as the main blood supply for P-HCC, whereas extrahepatic collateral arteries were complementary to P-HCC, regardless of whether the patient was pre- or post‑TACE. Extrahepatic collateral supplies to P‑HCCs that originated from adjacent vessels were rich, were closely associated with tumor size, and were prone to be newly established following repeated TACE.
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1 

Eggel H: Uber das primare Carcinom der Leber. Beitr Pathol Anat Allg Pathol. 30:506–604. 1901.

2 

Roux: Un cas de cancer primitif du foie avec pericholecystite calculeuse, perforation intestinale: Hemostase hepatique. Rev Med Suisse Romande. 17:114–119. 1897.

3 

Horie Y, Katoh S, Yoshida H, Imaoka T, Suou T and Hirayama C: Pedunculated hepatocellular carcinoma. Report of three cases and review of the literature. Cancer. 51:746–751. 1983. View Article : Google Scholar : PubMed/NCBI

4 

Horie Y, Shigoku A, Tanaka H, Tomie Y, Maeda N, Hoshino U, Koda M, Shiota G, Yamamoto T, Kato S, et al: Prognosis for pedunculated hepatocellular carcinoma. Oncology. 57:23–28. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Yeh CN, Lee WC, Jeng LB and Chen MF: Pedunculated hepatocellular carcinoma: Clinicopathologic study of 18 surgically resected cases. World J Surg. 26:1133–1138. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Moritz MW, Shoji M, Sicard GA, Shioda R and DeSchryver K: Surgical therapy in two patients with pedunculated hepatocellular carcinoma. Arch Surg. 123:772–774. 1988. View Article : Google Scholar : PubMed/NCBI

7 

Anthony PP and James K: Pedunculated hepatocellular carcinoma. Is it an entity? Histopatholoy. 11:403–414. 1987.

8 

Lopez PM, Villanueva A and Llovet JM: Systematic review: Evidence-based management of hepatocellular carcinoma-an updated analysis of randomized controlled trials. Aliment Pharmacol Ther. 23:1535–1547. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT, Fan ST and Wong J: Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 35:1164–1171. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Llovet JM, Real MI, Montana X, Planas R, Coll S, Aponte J, Ayuso C, Sala M, Muchart J, Solà R, et al: Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial. Lancet. 359:1734–1739. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Yang P, Zeng ZC, Wang BL, Zhang JY, Fan J, Zhou J and Hu Y: The degree of Lipiodol accumulation can be an indicator of successful treatment for unresectable hepatocellular carcinoma (HCC) patients-in the case of transcatheter arterial chemoembolization (TACE) and external beam radiotherapy (EBRT). J Cancer. 7:1413–1420. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Miyayama S, Matsui O, Taki K, Minami T, Ryu Y, Ito C, Nakamura K, Inoue D, Notsumata K, Toya D, et al: Extrahepatic blood supply to hepatocellular carcinoma: Angiographic demonstration and transcatheter arterial chemoembolization. Cardiovasc Intervent Radiol. 29:39–48. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Yuminaga Y, Kam J and Louie-Johnsun M: Multi-centre, prospective evaluation of the Seldinger technique for difficult male urethral catheter insertions by non-urology trained doctors. BJU Int. 120:(Suppl 3): S21–S27. 2017. View Article : Google Scholar

14 

Huang D, Chen Y, Chen S, Zeng Q, Zhao J, Wu R and Li Y: TACE plus percutaneous chemotherapy-lipiodol treatment of unresectable pedunculated hepatocellular carcinoma. Medicine. 96:e76502017. View Article : Google Scholar : PubMed/NCBI

15 

Charnsangavej C, Chuang VP, Wallace S, Soo CS and Bowers T: Angiographic classification of hepatic arterial collaterals. Radiology. 144:485–494. 1982. View Article : Google Scholar : PubMed/NCBI

16 

Michels NA: Collateral arterial pathways to the liver after ligation of the hepatic artery and removal of the celiac axis. Cancer. 6:708–724. 1953. View Article : Google Scholar : PubMed/NCBI

17 

Koehler RE, Korobkin M and Lewis F: Arteriographic demonstration of collateral arterial supply to the liver after hepatic artery ligation. Radiology. 117:49–54. 1975. View Article : Google Scholar : PubMed/NCBI

18 

Miyayama S, Matsui O, Akakura Y, Yamamoto T, Nishida H, Yoneda K, Kawai K and Nishijima H: Hepatocellular carcinoma with blood supply from omental branches: Treatment with transcatheter arterial embolization. J Vasc Interv Radiol. 12:1285–1290. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Chung JW, Park JH, Han JK, Choi BI, Kim TK and Han MC: Transcatheter oily chemoembolization of the inferior phrenic artery in hepatocellular carcinoma: The safety and potential therapeutic role. J Vasc Interv Radiol. 9:495–500. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Hirota S, Matsumoto S, Fukuda T, Yoshikawa T, Motohara T and Ichikawa S: Solitary hepatocellular carcinoma fed by the cystic artery: Limitation of transcatheter arterial embolization. Cardiovasc Intervent Radiol. 22:206–209. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Tanigawa N, Sawada S, Okuda Y, Shinzato S, Mishima K, Asai T, Ohmura N and Kobayashi M: A case of small hepatocellular carcinoma supplied by the cystic artery. AJR Am J Roentgenol. 170:675–676. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Park SI, Lee DY, Won JY and Lee JT: Extrahepatic collateral supply of hepatocellular carcinoma by the intercostal arteries. J Vasc Interv Radiol. 14:461–468. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Soo CS, Chuang VP, Wallace S, Charnsangavej C and Carrasco H: Treatment of hepatic neoplasm through extrahepatic collaterals. Radiology. 147:45–49. 1983. View Article : Google Scholar : PubMed/NCBI

24 

Kim JH, Chung JW, Han JK, Park JH, Choi BI and Han MC: Transcatheter arterial embolization of the internal mammary artery in hepatocellular carcinoma. J Vasc Interv Radiol. 6:71–77. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Duprat G, Charnsangavej C, Wallace S and Carrasco CH: Inferior phrenic artery embolization in the treatment of hepatic neoplasms. Acta Radiol. 29:427–429. 1988. View Article : Google Scholar : PubMed/NCBI

26 

Nakai M, Sato M, Kawai N, Minamiguchi H, Masuda M, Tanihata H, Takeuchi T, Terada M and Kishi K: Hepatocellular carcinoma: Involvement of the internal mammary artery. Radiology. 219:147–152. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Kodama Y, Shimizu T, Endo H, Hige S, Kamishima T, Holland GA, Miyamoto N and Miyasaka K: Spontaneous rupture of hepatocellular carcinoma supplied by the right renal capsular artery treated by transcatheter arterial embolization. Cardiovasc Intervent Radiol. 25:137–140. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Miyayama S, Matsui O, Nishida H, Yamamori S, Minami T, Shinmura R, Kozaka K, Notsumata K, Toya D, Tanaka N, et al: Transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma fed by the cystic artery. J Vasc Interv Radiol. 14:1155–1161. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Miyayama S, Matsui O, Taki K, Minami T, Ito C, Shinmura R, Takamatsu S, Kobayashi M, Notsumata K, Toya D, et al: Transcatheter arterial chemoembolization for hepatocellular carcinoma fed by the reconstructed inferior phrenic artery: Anatomical and technical analysis. J Vasc Interv Radiol. 15:815–823. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Nishizaki T, Matsumata T, Adachi E, Hayashi H and Sugimachi K: Pedunculated hepatocellular carcinoma and surgical treatment. Br J Cancer. 67:115–118. 1993. View Article : Google Scholar : PubMed/NCBI

31 

Chung GE, Lee JH, Kim HY, Hwang SY, Kim JS, Chung JW, Yoon JH, Lee HS and Kim YJ: Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology. 258:627–634. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Becher G, Sozgen T, Olschewski M, Laubenberger J, Blum HE and Allgaier HP: Combined TACE and PEI for paliative treatment of unresectable hepatocellular carcinoma. World J Gastroenterol. 11:6104–6109. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang D, Chen Y, Zeng Q, Zhao J, Wu X, Wu R and Li Y: Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration. Oncol Lett 15: 3383-3389, 2018.
APA
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., & Li, Y. (2018). Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration. Oncology Letters, 15, 3383-3389. https://doi.org/10.3892/ol.2018.7844
MLA
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., Li, Y."Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration". Oncology Letters 15.3 (2018): 3383-3389.
Chicago
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., Li, Y."Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration". Oncology Letters 15, no. 3 (2018): 3383-3389. https://doi.org/10.3892/ol.2018.7844
Copy and paste a formatted citation
x
Spandidos Publications style
Huang D, Chen Y, Zeng Q, Zhao J, Wu X, Wu R and Li Y: Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration. Oncol Lett 15: 3383-3389, 2018.
APA
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., & Li, Y. (2018). Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration. Oncology Letters, 15, 3383-3389. https://doi.org/10.3892/ol.2018.7844
MLA
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., Li, Y."Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration". Oncology Letters 15.3 (2018): 3383-3389.
Chicago
Huang, D., Chen, Y., Zeng, Q., Zhao, J., Wu, X., Wu, R., Li, Y."Blood supply characteristics of pedunculated hepatocellular carcinoma prior to and following transcatheter arterial chemoembolization treatment: An angiographic demonstration". Oncology Letters 15, no. 3 (2018): 3383-3389. https://doi.org/10.3892/ol.2018.7844
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