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Article

Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy

  • Authors:
    • Yajie Zhao
    • Lin Shen
    • Xinqiong Huang
    • Yuxiang He
    • Jun Fu
    • Yujie Qian
    • Shan Li
    • Na Zhao
    • Liangfang Shen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Hospital Management Consulting Center, National Institute of Hospital Administration, Beijing 100083, P.R. China
  • Pages: 4445-4450
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    Published online on: January 24, 2018
       https://doi.org/10.3892/ol.2018.7850
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Abstract

The present study retrospectively analyzed the prognostic factors of 135 patients with locally advanced nasopharyngeal carcinoma (NPC) who received intensity modulated radiation therapy between August 2008 and January 2012 at Xiangya Hospital of Central South University. Patients were staged from III‑IVA according to the 7th American Joint Committee on Cancer staging system. Using Statistical Analysis System 9.3 software, the present study demonstrated that, among these 135 patients, the 5‑year overall survival, the 5‑year local relapse‑free survival, and the 5‑year disease metastasis‑free survival were 84, 82, and 78%, respectively. Multivariate Cox regression analysis identified that targeted treatment [hazard ratio (95% confidence interval), 2.642 (1.001, 6.972); P=0.0497] served as an independent negative prognostic factor in locally advanced NPC. The results of immunostaining revealed that the staining intensity of the radiation‑resistant group was increased compared with that of the radiation‑sensitive group. These results demonstrate that a high expression of EGFR may be associated with radiation resistance, and targeted treatment may not be effective in patients with locally advanced nasopharyngeal carcinoma with low expression of EGFR.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Wei WI and Sham JS: Nasopharyngeal carcinoma. Lancet. 365:2041–2054. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Chang JT, See LC, Liao CT, Ng SH, Wang CH, Chen IH, Tsang NM, Tseng CK, Tang SG and Hong JH: Locally recurrent nasopharyngeal carcinoma. Radiother Onco1. 54:135–142. 2000. View Article : Google Scholar

4 

Stoker SD, van Diessen JNA, de Boer JP, Karakullukcu B, Leemans CR and Tan IB: Current treatment options for local residual nasopharyngeal carcinoma. Curr Treat Options Oncol. 14:475–491. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Qiu S, Lin S, Tham IW, Pan J, Lu J and Lu JJ: Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 83:676–683. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lee AW, Sze WM, Au JS, Leung SF, Leung TW, Chua DT, Zee BC, Law SC, Teo PM, Tung SY, et al: Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience. Int J Radiat Oncol Biol Phys. 61:1107–1116. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Yeh SA, Tang Y, Lui CC, Huang YJ and Huang EY: Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone. Int J Radiat Oncol Biol Phys. 62:672–679. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, et al: Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 64:47–56. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Vermorken JB and Specenier P: Optimal treatment for recurrent/metastatic head and neck cancer. Ann Oncol. 21 Suppl 7:vii252–vii261. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Bianco C, Tortora G, Bianco R, Caputo R, Veneziani BM, Caputo R, Damiano V, Troiani T, Fontanini G, Raben D, et al: Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res. 8:3250–3258. 2002.PubMed/NCBI

11 

Ai Z, Wang J, Wang Y, Lu L, Tong J and Teng Y: Overexpressed epidermal growth factor receptor (EGFR)-induced progestin insensitivity in human endometrial carcinoma cells by the EGFR/mitogen-activated protein kinase signaling pathway. Cancer. 116:3603–3613. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Pfister DG, Su YB, Kraus DH, Wolden SL, Lis E, Aliff TB, Zahalsky AJ, Lake S, Needle MN and Shaha AR: Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced squamous cell head and neck cancer: A pilot phase II study of a new combined-modality paradigm. J Clin Oncol. 24:1072–1078. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Du Y, Peyser ND and Grandis JR: Integration of molecular targeted therapy with radiation in head and neck cancer. Pharmacol Ther. 142:88–98. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, et al: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 354:567–578. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash andsurvival. Lancet Oncol. 11:21–28. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Cohen RB: Current challenges and clinical investigations of epidermal growth factor receptor (EGFR) and ErbB family-targeted agents in the treatmentof head and neck squamous cell carcinoma (HNSCC). Cancer Treat Rev. 40:567–577. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Huang XQ, Chen X, Xie XX, Zhou Q, Li K, Li S, Shen LF and Su J: Co-expression of CD147 and GLUT-1 indicates radiation resistance and poor prognosis in cervical squamous cell carcinoma. Int J Clin Exp Pathol. 7:1651–1666. 2014.PubMed/NCBI

20 

Zhao Y, Shen L, Chen X, Qian Y, Zhou Q, Wang Y, Li K, Liu M, Zhang S and Huang X: High expression of PKM2 as a poor prognosis indicatoris associated with radiation resistance in cervical cancer. Histol Histopathol. 30:1313–1320. 2015.PubMed/NCBI

21 

International Commission on Radiation Units and Measurements (ICRU), . ICRU Report: Prescribing, recording, and reporting photon beam therapy. 50. ICRU; Bethesda, MD: 1993

22 

International Commission on Radiation Units and Measurements (ICRU), . ICRU Report: Prescribing, recording, and reporting photon beam therapy. 62. ICRU; Bethesda, MD: 1999, (supplement to ICRU report 50).

23 

Zhao Y and Shen L, Huang X, Jing D, Huang D, Fu J, Li Z, Zhang G and Shen L: High expression of Ki-67 acts a poor prognosis indicator in locally advanced nasopharyngeal carcinoma. Biochem Biophys Res Commun. 494:390–396. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zhou Q, He Y, Zhao Y, Wang Y, Kuang W and Shen L: A study of 358 cases of locally advanced nasopharyngeal carcinoma receiving intensity-modulated radiation therapy: Improving the seventh edition of the American joint committee on cancer T-staging system. Biomed Res Int. 2017:14196762017.PubMed/NCBI

25 

Radiation Therapy Oncology Group, . A Phase II Study of Intensity Modulated Radiation Therapy (IMRT)+/− Chemotherapy for Nasopharyngeal Cancer. RTOG protocol 0225. 2014, https://www.rtog.org

26 

He Y, Zhou Q, Shen L, Zhao Y, Lei M, Wei R, Shen L and Cao S: A retrospective study of the prognostic value of MRI-derived residual tumors at the end ofintensity-modulated radiotherapy in 358 patients with locally-advanced nasopharyngeal carcinoma. Radiat Oncol. 10:892015. View Article : Google Scholar : PubMed/NCBI

27 

Liu X, Liu LZ, Mao YP, Chen L, Tang LL, Zhou GQ, Sun Y, Yue D, Lin AH, Li L and Ma J: Prognostic value ofmagnetic resonance imaging-detected cranial nerve invasion in nasopharyngeal carcinoma. Br J Cancer. 110:1465–1471. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Hsu HC, Chen CL, Hsu MM, Lynn TC, Tu SM and Huang SC: Pathology of nasopharyngeal carcinoma. Proposal of a new histologic classification correlated with prognosis. Cancer. 59:945–951. 1987. View Article : Google Scholar : PubMed/NCBI

29 

Yang S, Chen J, Guo Y, Lin H, Zhang Z, Feng G, Hao Y, Cheng J, Liang P, Chen K, et al: Identification of prognostic biomarkers for response to radiotherapy by DNA microarray in nasopharyngeal carcinoma patients. Int J Oncol. 40:1590–1600. 2012.PubMed/NCBI

30 

Little SE, Bax DA, Rodriguez-Pinilla M, Natrajan R, Messahel B, Pritchard-Jones K, Vujanic GM, Reis-Filho JS and Jones C: Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney. Clin Cancer Res. 13:4360–4364. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Ekstrand AJ, James CD, Cavenee WK, Seliger B, Pettersson RF and Collins VP: Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 51:2164–2172. 1991.PubMed/NCBI

32 

Qi DL, Cui Y, Wang QS, Huang CB, Xu J, Yang YZ, Xin L, Tian Y and Qi XA: A clinical trail on docetaxel and carboplatin therapy with or without nimotuzumab for the treatment of advanced nonsmall cell lung cancer. J Cancer Res Ther. 11 Suppl 1:C32–C37. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Shin DM, Ro JY, Hong WK and Hittelman WN: Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis. Cancer Res. 54:3153–3159. 1994.PubMed/NCBI

34 

Pan J, Tang T, Xu L, Lu JJ, Lin S, Qiu S, Chen G and K Tham IW: Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. Head Neck. 35:1238–1247. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Ma BB, Poon TC, To KF, Zee B, Mo FK, Chan CM, Ho S, Teo PM, Johnson PJ and Chan AC: Prognostic significance of tumor angiogenesis, Ki67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma-a prospective study. Head Neck. 25:864–872. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Soo R, Putti T, Tao Q, Goh BC, Lee KH, Kwok-Seng L, Tan L and Hsieh WS: Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. Arch Otolaryngol Head Neck Surg. 131:147–152. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Pan J, Kong L, Lin S, Chen G, Chen Q and Lu JJ: The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma. Laryngoscope. 118:1970–1975. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Lee SC, Lim SG, Soo R, Hsieh WS, Guo JY, Putti T, Tao Q, Soong R and Goh BC: Lack of somatic mutations in EGFR tyrosine kinase domain in hepatocellular and nasopharyngeal carcinoma. Pharmacogenet Genomics. 16:73–74. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Zhang ZC, Fu S, Wang F, Wang HY, Zeng YX and Shao JY: Oncogene mutational profile in nasopharyngeal carcinoma. Onco Targets Ther. 7:457–467. 2014.PubMed/NCBI

40 

Zuo Q, Shi M, Chen J and Liao W: The Ras signaling pathway mediates cetuximab resistance in nasopharyngeal carcinoma. Biomed Pharmacother. 65:168–174. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Fernández-Medarde A and Santos E: Ras in cancer and developmental diseases. Genes Cancer. 2:344–358. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Bozec A, Etienne-Grimaldi MC, Fischel JL, Sudaka A, Toussan N, Formento P and Milano G: The mTOR-targeting drug temsirolimus enhances the growth-inhibiting effects of the cetuximabbevacizumab-irradiation combination on head and neck cancer xenografts. Oral Oncol. 47:340–344. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Chung CH, Wang H, Tsottles N, Gourin CG, Agrawal N, Molinolo A, Gutkind S, Forastiere AA and Marur S: A phase I study of everolimus in combination with cetuximab and cisplatin as first-line therapy in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). J Clin Oncol Oncol Clin Oncol. 30 Suppl:2012.

44 

Argiris A, Ohr J, Kubicek GJ, Duvvuri U, Heron DE, Kotsakis AP, Spencer C, Kim S, Grandis JR, Johnson JT, et al: Phase II randomized trial of radiotherapy (RT), cetuximab (E), and pemetrexed (Pem) with or without bevacizumab (B) in locally advanced squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol. 31 Suppl:S6043. 2013.

45 

Xu M, Mizoguchi I, Morishima N, Chiba Y, Mizuguchi J and Yoshimoto T: Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clin Dev Immunol. 2010:8324542010. View Article : Google Scholar : PubMed/NCBI

46 

Yoo DS, Kirkpatrick JP, Craciunescu O, Broadwater G, Peterson BL, Carroll MD, Clough R, MacFall JR, Hoang J, Scher RL, et al: Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer. Clin Cancer Res. 18:1404–1414. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Argiris A, Kotsakis AP, Hoang T, Worden FP, Savvides P, Gibson MK, Gyanchandani R, Blumenschein GR Jr, Chen HX, Grandis JR, et al: Cetuximab and bevacizumab: Preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck. Ann Oncol. 24:220–225. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Liu MT, Chen MK, Huang CC and Huang CY: Prognostic value of molecular markers and implication for molecular targeted therapies in nasopharyngeal carcinoma: An update in an era of new targeted molecules development. World J Oncol. 6:243–261. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Shen L, Huang X, He Y, Fu J, Qian Y, Li S, Zhao N and Shen L: Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy. Oncol Lett 15: 4445-4450, 2018.
APA
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y. ... Shen, L. (2018). Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy. Oncology Letters, 15, 4445-4450. https://doi.org/10.3892/ol.2018.7850
MLA
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y., Li, S., Zhao, N., Shen, L."Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy". Oncology Letters 15.4 (2018): 4445-4450.
Chicago
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y., Li, S., Zhao, N., Shen, L."Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy". Oncology Letters 15, no. 4 (2018): 4445-4450. https://doi.org/10.3892/ol.2018.7850
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Shen L, Huang X, He Y, Fu J, Qian Y, Li S, Zhao N and Shen L: Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy. Oncol Lett 15: 4445-4450, 2018.
APA
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y. ... Shen, L. (2018). Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy. Oncology Letters, 15, 4445-4450. https://doi.org/10.3892/ol.2018.7850
MLA
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y., Li, S., Zhao, N., Shen, L."Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy". Oncology Letters 15.4 (2018): 4445-4450.
Chicago
Zhao, Y., Shen, L., Huang, X., He, Y., Fu, J., Qian, Y., Li, S., Zhao, N., Shen, L."Prognostic analysis of patients with locally advanced nasopharyngeal carcinoma following intensity modulated radiation therapy". Oncology Letters 15, no. 4 (2018): 4445-4450. https://doi.org/10.3892/ol.2018.7850
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