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Article Open Access

Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer

  • Authors:
    • Wei Liu
    • Hua Ye
    • Ying‑Fu Liu
    • Chao‑Qun Xu
    • Yue‑Xian Zhong
    • Tian Tian
    • Shi‑Wei Ma
    • Huan Tao
    • Ling Li
    • Li‑Chun Xue
    • Hua‑Qin He
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China, Department of Gastroenterology, Ningbo Medical Treatment Center Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China, Department of Cell Biology, Logistics University of Chinese Armed Police Forces, Tianjin 300309, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4351-4357
    |
    Published online on: January 25, 2018
       https://doi.org/10.3892/ol.2018.7855
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Abstract

The stromal and immune cells that form the tumor microenvironment serve a key role in the aggressiveness of tumors. Current tumor‑centric interpretations of cancer transcriptome data ignore the roles of stromal and immune cells. The aim of the present study was to investigate the clinical utility of stromal and immune cells in tissue‑based transcriptome data. The ‘Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data’ (ESTIMATE) algorithm was used to probe diverse cancer datasets and the fraction of stromal and immune cells in tumor tissues was scored. The association between the ESTIMATE scores and patient survival data was asessed; it was indicated that the two scores have implications for patient survival, metastasis and recurrence. Analysis of a colorectal cancer progression dataset revealed that decreased levels immune cells could serve an important role in cancer progression. The results of the present study indicated that trasncriptome‑derived stromal and immune scores may be a useful indicator of cancer prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Ye H, Liu YF, Xu CQ, Zhong YX, Tian T, Ma SW, Tao H, Li L, Xue LC, Xue LC, et al: Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. Oncol Lett 15: 4351-4357, 2018.
APA
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T. ... He, H. (2018). Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. Oncology Letters, 15, 4351-4357. https://doi.org/10.3892/ol.2018.7855
MLA
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T., Ma, S., Tao, H., Li, L., Xue, L., He, H."Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer". Oncology Letters 15.4 (2018): 4351-4357.
Chicago
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T., Ma, S., Tao, H., Li, L., Xue, L., He, H."Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer". Oncology Letters 15, no. 4 (2018): 4351-4357. https://doi.org/10.3892/ol.2018.7855
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Ye H, Liu YF, Xu CQ, Zhong YX, Tian T, Ma SW, Tao H, Li L, Xue LC, Xue LC, et al: Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. Oncol Lett 15: 4351-4357, 2018.
APA
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T. ... He, H. (2018). Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer. Oncology Letters, 15, 4351-4357. https://doi.org/10.3892/ol.2018.7855
MLA
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T., Ma, S., Tao, H., Li, L., Xue, L., He, H."Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer". Oncology Letters 15.4 (2018): 4351-4357.
Chicago
Liu, W., Ye, H., Liu, Y., Xu, C., Zhong, Y., Tian, T., Ma, S., Tao, H., Li, L., Xue, L., He, H."Transcriptome-derived stromal and immune scores infer clinical outcomes of patients with cancer". Oncology Letters 15, no. 4 (2018): 4351-4357. https://doi.org/10.3892/ol.2018.7855
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