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Article Open Access

Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma

  • Authors:
    • Chaobin He
    • Yize Mao
    • Xiangming Lao
    • Shengping Li
    • Xiaojun Lin
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Oncology, Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4262-4268
    |
    Published online on: January 26, 2018
       https://doi.org/10.3892/ol.2018.7882
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Abstract

The neutrophil-to-lymphocyte ratio (NLR) has been regarded as a prognostic factor in various types of cancer. The present study aimed to identify the association between NLR and combined hepatocellular cholangiocarcinoma (cHCC‑CC) in patients who underwent surgical resection. The present study retrospectively reviewed 59 patients who were diagnosed with cHCC‑CC and treated with surgical resection between January 2000 and October 2014 at the Department of Hepatobiliary and Pancreatic Surgery at Sun Yat‑sen University Cancer Center (Guangzhou, China). The patients were divided into two groups: NLR≤2.75 and NLR>2.75. Patients with stage I and II or stage III and IV disease were classified into early‑ and advanced‑stage groups, respectively, according to the Tumor‑Node‑Metastasis (TNM) staging system. Overall survival time (OS) was estimated using the Kaplan‑Meier method. Univariate and multivariate Cox regression models were used to evaluate the prognostic value of NLR. The NLR value was significantly higher in the HCC advanced‑stage group compared with that in the HCC early‑stage group according to the TNM staging system (3.19 vs. 2.00; P=0.001). The median survival time was 83.6 months in the NLR≤2.75 group and 15 months in the NLR>2.75 group (P=0.004). Upon multivariate analysis, NLR>2.75 was an independent prognostic factor for poor cHCC‑CC outcomes. Overall, the easily evaluated pre‑treatment NLR may be an independent prognostic factor for patients with cHCC-CC treated by surgical resection.
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Copy and paste a formatted citation
Spandidos Publications style
He C, Mao Y, Lao X, Li S and Lin X: Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma. Oncol Lett 15: 4262-4268, 2018.
APA
He, C., Mao, Y., Lao, X., Li, S., & Lin, X. (2018). Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma. Oncology Letters, 15, 4262-4268. https://doi.org/10.3892/ol.2018.7882
MLA
He, C., Mao, Y., Lao, X., Li, S., Lin, X."Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma". Oncology Letters 15.4 (2018): 4262-4268.
Chicago
He, C., Mao, Y., Lao, X., Li, S., Lin, X."Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma". Oncology Letters 15, no. 4 (2018): 4262-4268. https://doi.org/10.3892/ol.2018.7882
Copy and paste a formatted citation
x
Spandidos Publications style
He C, Mao Y, Lao X, Li S and Lin X: Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma. Oncol Lett 15: 4262-4268, 2018.
APA
He, C., Mao, Y., Lao, X., Li, S., & Lin, X. (2018). Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma. Oncology Letters, 15, 4262-4268. https://doi.org/10.3892/ol.2018.7882
MLA
He, C., Mao, Y., Lao, X., Li, S., Lin, X."Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma". Oncology Letters 15.4 (2018): 4262-4268.
Chicago
He, C., Mao, Y., Lao, X., Li, S., Lin, X."Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma". Oncology Letters 15, no. 4 (2018): 4262-4268. https://doi.org/10.3892/ol.2018.7882
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