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Article

PRR4: A novel downregulated gene in laryngeal cancer

  • Authors:
    • Seda Ekizoglu
    • Turgut Ulutin
    • Jalal Guliyev
    • Nur Buyru
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey, Department of Otorhinolaryngology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey
  • Pages: 4669-4675
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7888
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Abstract

Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor types, including neoplasia of the paranasal sinuses, oral cavity, trachea, pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The proline‑rich 4 (PRR4) protein is synthesized in the acinar cells of human lacrimal glands. Previous studies have demonstrated that PRR4 may function as an antimicrobial protein protecting the ocular surface and the oral cavity. In order to determine differentially expressed genes (DEGs) in laryngeal tumors, a GeneFishing Assay was performed; 27 DEGs were identified. The PRR4 gene expression level in laryngeal tissue samples obtained from 90 patients, and the saliva of 25 healthy smokers and 25 non‑smokers, was investigated using reverse transcription‑quantitative polymerase chain reaction. It was revealed that PRR4 gene expression was decreased in 65/90 tumor tissues (72.2%) compared with normal tissues. No significant difference was identified between the healthy smoker and the non‑smoker groups in terms of PRR4 gene expression. The results of the present study indicated that the PRR4 gene may serve an important role in laryngeal carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Ekizoglu S, Ulutin T, Guliyev J and Buyru N: PRR4: A novel downregulated gene in laryngeal cancer. Oncol Lett 15: 4669-4675, 2018.
APA
Ekizoglu, S., Ulutin, T., Guliyev, J., & Buyru, N. (2018). PRR4: A novel downregulated gene in laryngeal cancer. Oncology Letters, 15, 4669-4675. https://doi.org/10.3892/ol.2018.7888
MLA
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15.4 (2018): 4669-4675.
Chicago
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15, no. 4 (2018): 4669-4675. https://doi.org/10.3892/ol.2018.7888
Copy and paste a formatted citation
x
Spandidos Publications style
Ekizoglu S, Ulutin T, Guliyev J and Buyru N: PRR4: A novel downregulated gene in laryngeal cancer. Oncol Lett 15: 4669-4675, 2018.
APA
Ekizoglu, S., Ulutin, T., Guliyev, J., & Buyru, N. (2018). PRR4: A novel downregulated gene in laryngeal cancer. Oncology Letters, 15, 4669-4675. https://doi.org/10.3892/ol.2018.7888
MLA
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15.4 (2018): 4669-4675.
Chicago
Ekizoglu, S., Ulutin, T., Guliyev, J., Buyru, N."PRR4: A novel downregulated gene in laryngeal cancer". Oncology Letters 15, no. 4 (2018): 4669-4675. https://doi.org/10.3892/ol.2018.7888
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