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Article

MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Ru‑Ting Xie
    • Xian‑Ling Cong
    • Xiao‑Ming Zhong
    • Ping Luo
    • Hui‑Qiong Yang
    • Gai‑Xia Lu
    • Pei Luo
    • Zheng‑Yan Chang
    • Ran Sun
    • Ting‑Miao Wu
    • Zhong‑Wei Lv
    • Da Fu
    • Yu‑Shui Ma
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Tissue Bank, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Department of Radiology, Jiangxi Provincial Tumor Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Breast Cancer, Nanchang Third Hospital, Nanchang, Jiangxi 330002, P.R. China, Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 4571-4577
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7892
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Abstract

In order to examine the prognostic significance of miR‑33a in patients with hepatocellular carcinoma (HCC), total RNA was extracted from 149 HCC biopsies, 36 of which were paired with para‑carcinoma tissues, and miR‑33a expression was measured by reverse transcription-quantitative polymerase chain reaction. The results demonstrated that miR‑33a expression was decreased in HCC biopsies compared with normal liver tissue samples. It was also demonstrated that miR‑33a expression was significantly associated with tumor foci number. Furthermore, overall and progression‑free survival time was decreased in patients expressing low miR‑33a with multiple tumor foci. Taken together, the low expression of miR‑33a may be a potential risk factor for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Xie RT, Cong XL, Zhong XM, Luo P, Yang HQ, Lu GX, Luo P, Chang ZY, Sun R, Wu TM, Wu TM, et al: MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 15: 4571-4577, 2018.
APA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G. ... Ma, Y. (2018). MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 15, 4571-4577. https://doi.org/10.3892/ol.2018.7892
MLA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15.4 (2018): 4571-4577.
Chicago
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15, no. 4 (2018): 4571-4577. https://doi.org/10.3892/ol.2018.7892
Copy and paste a formatted citation
x
Spandidos Publications style
Xie RT, Cong XL, Zhong XM, Luo P, Yang HQ, Lu GX, Luo P, Chang ZY, Sun R, Wu TM, Wu TM, et al: MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 15: 4571-4577, 2018.
APA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G. ... Ma, Y. (2018). MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 15, 4571-4577. https://doi.org/10.3892/ol.2018.7892
MLA
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15.4 (2018): 4571-4577.
Chicago
Xie, R., Cong, X., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z., Sun, R., Wu, T., Lv, Z., Fu, D., Ma, Y."MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 15, no. 4 (2018): 4571-4577. https://doi.org/10.3892/ol.2018.7892
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