Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

  • Authors:
    • Yingkun Pan
    • Yi Mei Zheng
    • Wing Shing Ho
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, The Chinese University of Hong Kong, Shatin, 011‑852 Hong Kong, SAR, P.R. China, Minnan Normal University, College of Biological Science and Technology, Zhangzhou, Fujian 363000, P.R. China
  • Pages: 4657-4661
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7893
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the effects of quercetin glucosides, which were isolated from the Chinese onion (Allium chinense), garlic (Allium sativum), onion (Allium cepa L.) and the Welsh onion (Allium fistulosum L.) in HepG2, HT‑29 and PC‑3 cancer cell lines. Quercetin‑3,4'‑di‑O‑glucoside (3,4'‑Qdg) and quercetin‑4'‑O‑glucoside (4'‑Qmg) comprise ~98% of the flavonoids in the methanol extract of onion. A small amount of 3,4'‑Qdg is present in the Welsh onion and Chinese onion, whereas 4'‑Qmg is also present in the Welsh onion. In HepG2 cells, 4'‑Qmg was demonstrated to exhibit more significant growth inhibition compared with 3,4'‑Qdg and quercetin 3‑β‑D‑glucoside, but exhibited less inhibitory effects in PC‑3 and HT‑29 cells. These results suggest the anti‑proliferative potential of 4'‑Qmg in various cancer cell lines and the health benefits of the genus Allium. The findings indicate the potential of 4'‑Qmg as an anticancer agent for further development.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Slimestad R, Fossen T and Vågen IM: Onions: A source of unique dietary flavonoids. J Agric Food Chem. 55:10067–10080. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Lee J and Mitchell AE: Pharmacokinetics of quercetin absorption from apples and onions in healthy humans. J Agric Food Chem. 60:3874–3881. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Bae CR, Park YK and Cha YS: Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes. J Sci Food Agric. 94:2655–2660. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kiokias S and Varzakas T: Activity of flavonoids and β-carotene during the auto-oxidative deterioration of model food oil-in water emulsions. Food Chem. 150:280–286. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Williamson G, Plumb GW, Uda Y, Price KR and Rhodes MJ: Dietary quercetin glycosides: Antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis. 17:2385–2387. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Yang J, Meyers KJ, van der Heide J and Liu RH: Varietal differences in phenolic content and antioxidant and antiproliferative activities of onions. J Agric Food Chem. 52:6787–6793. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lin S, Zhu Q, Wen L, Yang B, Jiang G, Gao H, Chen F and Jiang Y: Production of quercetin, kaempferol and their glycosidic derivatives from the aqueous-organic extracted residue of litchi pericarp with Aspergillus awamori. Food Chem. 145:220–227. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zielińska M, Gülden M and Seibert H: Effects of quercetin and quercetin-3-O-glycosides on oxidative damage in rat C6 glioma cells. Environ Toxicol Pharmacol. 13:47–53. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Rohn S, Buchner N, Driemel G, Rauser M and Kroh LW: Thermal degradation of onion quercetin glucosides under roasting conditions. J Agric Food Chem. 55:1568–1573. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Caridi D, Trenerry VC, Rochfort S, Duong S, Laugher D and Jones R: Profiling and quantifying quercetin glucosides in onion (Allium cepa L.) varieties using capillary zone electrophoresis and high performance liquid chromatography. Food Chem. 105:691–699. 2007. View Article : Google Scholar

11 

Wagner C, Fachinetto R, Dalla Corte CL, Brito VB, Severo D, de Oliveira Costa Dias G, Morel AF, Nogueira CW and Rocha JB: Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro. Brain Res. 1107:192–198. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Yang WS, Jeong D, Yi YS, Lee BH, Kim TW, Htwe KM, Kim YD, Yoon KD, Hong S, Lee WS and Cho JY: Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1. J Ethnopharmacol. 151:1165–1174. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sugantha Priya E, Selvakumar K, Bavithra S, Elumalai P, Arunkumar R, Raja Singh P, Brindha Mercy A and Arunakaran J: Anti-cancer activity of quercetin in neuroblastoma: An in vitro approach. Neurol Sci. 35:163–170. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Cao HH, Tse AK, Kwan HY, Yu H, Cheng CY, Su T, Fong WF and Yu ZL: Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 87:424–434. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Žižková P, Blaškovič D, Májeková M, Švorc L, Račková L, Ratkovská L, Veverka M and Horáková L: Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1. Mol Cell Biochem. 386:1–14. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hollman PC, de Vries JH, Van Leeuwen SD, Mengelers MJ and Katan MB: Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin. Nutr. 62:1276–1282. 1995.

17 

Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH and Katan MB: Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett. 114:139–140. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Marotti M and Piccaglia R: Characterization of flavonoids in different cultivars of onion (Allium cepa L.). J Food Sci. 67:1229–1232. 2002. View Article : Google Scholar

19 

Lu X, Ross CF, Powers JR and Rasco BA: Determination of quercetins in onion (Allium cepa) using infrared spectroscopy. J Agric Food Chem. 59:6376–6382. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Yang HH, Hwangbo K, Zheng MS, Cho JH, Son JK, Kim HY, Baek SH, Choi HC, Park SY and Kim JR: Quercetin-3-O-β-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch Pharm Res. 37:1219–1233. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Li W, Liu M, Xu YF, Feng Y, Che JP, Wang GC and Zheng JH: Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. Oncol Rep. 31:117–124. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Chen JY, Hu RY and Chou HC: Quercetin-induced cardioprotection against doxorubicin cytotoxicity. J Biomed Sci. 20:952013. View Article : Google Scholar : PubMed/NCBI

23 

Chang YC, Tsai MH, Sheu WH, Hsieh SC and Chiang AN: The therapeutic potential and mechanisms of action of quercetin in relation to lipopolysaccharide-induced sepsis in vitro and in vivo. PLoS One. 8:e807442013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pan Y, Zheng Y and Ho W: Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines. Oncol Lett 15: 4657-4661, 2018.
APA
Pan, Y., Zheng, Y., & Ho, W. (2018). Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines. Oncology Letters, 15, 4657-4661. https://doi.org/10.3892/ol.2018.7893
MLA
Pan, Y., Zheng, Y., Ho, W."Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines". Oncology Letters 15.4 (2018): 4657-4661.
Chicago
Pan, Y., Zheng, Y., Ho, W."Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines". Oncology Letters 15, no. 4 (2018): 4657-4661. https://doi.org/10.3892/ol.2018.7893
Copy and paste a formatted citation
x
Spandidos Publications style
Pan Y, Zheng Y and Ho W: Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines. Oncol Lett 15: 4657-4661, 2018.
APA
Pan, Y., Zheng, Y., & Ho, W. (2018). Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines. Oncology Letters, 15, 4657-4661. https://doi.org/10.3892/ol.2018.7893
MLA
Pan, Y., Zheng, Y., Ho, W."Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines". Oncology Letters 15.4 (2018): 4657-4661.
Chicago
Pan, Y., Zheng, Y., Ho, W."Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines". Oncology Letters 15, no. 4 (2018): 4657-4661. https://doi.org/10.3892/ol.2018.7893
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team