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RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis

  • Authors:
    • Feng Shen
    • Qing Guo
    • Qi Hu
    • Ailiang Zeng
    • Weining Wu
    • Wei Yan
    • Yongping You
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Oncology, People's Hospital of Taizhou, Taizhou, Jiangsu 225300, P.R. China, Department of Neurosurgery, The First People's Hospital of Yueyang, Yueyang, Hunan 414000, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4404-4410
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7894
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Abstract

Nuclear factor κB (NF‑κB) exhibits an important role in inflammation and tumorigenesis. The key regulatory protein of the pathway, RELB Proto‑Oncogene, NF‑KB Subunit (relB), is overexpressed and associated with the pathogenesis of a variety of malignant tumors. However, the molecular features and clinical signature of relB expression in gliomas remains to be elucidated. The present study obtained the raw sequencing data of 325 glioma samples of all grades from the Chinese Glioma Genome Atlas (CGGA) database and human glioma cell line (LN229) from the Chinese Academy of Sciences cell bank. Cell proliferation, invasion and wound healing assays were used for functional annotation of relB. Western blot analysis was used for validating the protein expression of relB, matrix metalloproteinase (MMP)‑2 and MMP‑9 in a further 77 glioma samples. In Diffuse Glioma data, relB expression was associated with glioma grade, demonstrated a mesenchymal subtype preference and cell development association. The downregulation of relB expression inhibited glioma cell migration and invasion by regulating the MMPs in vitro. relB expression was independently associated with grade and prognosis of grade III and grade IV gliomas, suggesting that relB is a novel biomarker with therapeutic potential for predicting prognosis in glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Shen F, Guo Q, Hu Q, Zeng A, Wu W, Yan W and You Y: RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis. Oncol Lett 15: 4404-4410, 2018.
APA
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., & You, Y. (2018). RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis. Oncology Letters, 15, 4404-4410. https://doi.org/10.3892/ol.2018.7894
MLA
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., You, Y."RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis". Oncology Letters 15.4 (2018): 4404-4410.
Chicago
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., You, Y."RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis". Oncology Letters 15, no. 4 (2018): 4404-4410. https://doi.org/10.3892/ol.2018.7894
Copy and paste a formatted citation
x
Spandidos Publications style
Shen F, Guo Q, Hu Q, Zeng A, Wu W, Yan W and You Y: RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis. Oncol Lett 15: 4404-4410, 2018.
APA
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., & You, Y. (2018). RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis. Oncology Letters, 15, 4404-4410. https://doi.org/10.3892/ol.2018.7894
MLA
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., You, Y."RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis". Oncology Letters 15.4 (2018): 4404-4410.
Chicago
Shen, F., Guo, Q., Hu, Q., Zeng, A., Wu, W., Yan, W., You, Y."RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis". Oncology Letters 15, no. 4 (2018): 4404-4410. https://doi.org/10.3892/ol.2018.7894
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