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Case Report

Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review

  • Authors:
    • Jing‑Yu Hu
    • Dan Yu
    • Yao‑Hui Wu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 4427-4431
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7895
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Abstract

Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B‑cell primary non‑Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7‑year period of complete remission, a new, similar lesion was identified in the left femur. With both lesions, there was no accompanying destruction of any other bones or organ involvement. Metastasis of PLB to the contralateral side is extremely rare and, to the best of our knowledge, this is the first report of this particular presentation in China or worldwide. We hypothesized that the present situation arose due to mechanisms involving the tumor microenvironment, circulating tumor cells, lymphocyte homing and self‑seeding. The present report describes the case in detail, and discusses the possible underlying mechanisms and their potential contribution to the treatment of non‑Hodgkin lymphoma, as well as the prevention of metastasis and recurrence, which may be of considerable clinical significance.
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1 

Aziz F: Primary non-Hodgkin lymphoma of the bone. J Cancer Res Ther. 5:3312009. View Article : Google Scholar : PubMed/NCBI

2 

Bruno Ventre M, Ferreri AJ, Gospodarowicz M, Govi S, Messina C, Porter D, Radford J, Heo DS, Park Y, Martinelli G, et al: Clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-Cell lymphoma of the bone (the IELSG-14 study). Oncologist. 19:291–298. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Hwang J, Cho S, Kim O, Shim HJ, Lee SR, Ahn JS, Yang DH, Kim YK, Lee JJ, Kim HJ and Chung IJ: Newly developed multiple myeloma in a patient with primary T-Cell lymphoma of bone. J Korean Med Sci. 23:544–547. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Fletcher CD: The evolving classification of soft tissue tumours: An update based on the new WHO classification. Histopathology. 48:3–12. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Stein ME, Kuten A, Gez E, Rosenblatt KE, Drumea K, Ben-Shachar M, Zidan J, Haim N and Epelbaum R: Primary lymphoma of bone: A retrospective study. Oncology. 64:322–327. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Beal K, Allen L and Yahalom J: Primary bone lymphoma: Treatment results and prognostic factors with long-term follow-up of 82 patients. Cancer. 106:2652–2656. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Wu H, Zhang L, Shao H, Sokol L, Sotomayor E, Letson D and Bui MM: Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: A single institutional experience. Br J Haematol. 166:60–68. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Vertinksy AT, Krasnokutsky MV, Augustin M and Bammer R: Cutting-edge imaging of the spine. Neuroimaging Clin N Am. 17:117–136. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Jawad MU, Schneiderbauer MM, Min ES, Cheung MC, Koniaris LG and Scully SP: Primary lymphoma of bone in adult patients. Cancer. 116:871–879. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Zhang X, Zhu J, Song Y, Ping L and Zheng W: Clinical characterization and outcome of primary bone lymphoma: A retrospective study of 61 Chinese patients. Sci Rep. 6:288342016. View Article : Google Scholar : PubMed/NCBI

11 

Zinzani PL, Carrillo G, Ascani S, Barbieri E, Tani M, Paulli M, Stefoni V, Sabattini E, Alinari L, Binazzi R, et al: Primary bone lymphoma: Experience with 52 patients. Haematologica. 88:280–285. 2003.PubMed/NCBI

12 

Baar J, Burkes RL, Bell R, Blackstein ME, Fernandes B and Langer F: Primary non-Hodgkin lymphoma of the bone. A clinicopathologic study. Cancer. 73:1194–1199. 1994. View Article : Google Scholar : PubMed/NCBI

13 

Salmi M and Jalkanen S: Lymphocyte homing to the gut: Attraction, adhesion, and commitment. Immunol Rev. 206:100–113. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Piovan E, Tosello V, Indraccolo S, Masiero M, Persano L, Esposito G, Zamarchi R, Ponzoni M, Chieco-Bianchi L, Dalla-Favera R and Amadori A: Differential regulation of hypoxia-induced CXCR4 triggering during B-Cell development and lymphomagenesis. Cancer Res. 67:8605–8614. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Norton L and Massagué J: Is cancer a disease of self-seeding? Nat Med. 12:875–878. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Leung CT and Brugge JS: Tumor self-seeding: Bidirectional flow of tumor cells. Cell. 139:1226–1228. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Carmellet P and Jain RK: Angiogenesis in cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, et al: CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 11:812–824. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Burger JA and Gribben JG: The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies. Semin Cancer Biol. 24:71–81. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Reddy BY, Lim PK, Silverio K, Patel SA, Won BW and Rameshwar P: The microenvironmental effect in the progression, metastasis, and dormancy of breast cancer: A model system within bone marrow. Int J Breast Cancer. 2012:7216592012. View Article : Google Scholar : PubMed/NCBI

21 

Bates DO, Lodwick D and Williams B: Vascular endothelial growth factor and microvascular permeability. Microcirculation. 6:83–96. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Blagoev KB: Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche. Proc Natl Acad Sci USA. 108:pp. 19216–19221. 2011; View Article : Google Scholar : PubMed/NCBI

23 

Joosse SA and Pantel K: Biologic challenges in the detection of circulating tumor cells. Cancer Res. 73:8–11. 2013. View Article : Google Scholar : PubMed/NCBI

24 

van Laarhoven HW, Gambarota G, Heerschap A, Lok J, Verhagen I, Corti A, Toma S, Gallo Stampino C, van der Kogel A and Punt CJ: Effects of the tumor vasculature targeting agent NGR-TNF on the tumor microenvironment in murine lymphomas. Invest New Drugs. 24:27–36. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Dondossola E, Dobroff AS, Marchiò S, Cardó-Vila M, Hosoya H, Libutti SK, Corti A, Sidman RL, Arap W and Pasqualini R: Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proc Natl Acad Sci USA. 113:pp. 2223–2228. 2016; View Article : Google Scholar : PubMed/NCBI

26 

Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L and Massagué J: Tumor self-seeding by circulating cancer cells. Cell. 139:1315–1326. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Blonska M, Agarwal NK and Vega F: Shaping of the tumor microenvironment: Stormal cells and vessels. Semin Cancer Biol. 34:3–13. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Mao Y, Keller ET, Garfield DH, Shen K and Wang J: Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev. 32:303–315. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Kamińska K, Szczylik C, Bielecka ZF, Bartnik E, Porta C, Lian F and Czarnecka AM: The role of the cell-cell interactions in cancer progression. J Cell Mol Med. 19:283–296. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Doñate C, Ody C, Mckee T, Ruault-Jungblut S, Fischer N, Ropraz P, Imhof BA and Matthes T: Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C. Cancer Res. 73:640–651. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Desgrosellier JS and Cheresh DA: Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer. 10:9–22. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Kaufmann H, Raderer M, Wöhrer S, Püspök A, Bankier A, Zielinski C, Chott A and Drach J: Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma. Blood. 104:2269–2271. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Coupland SE: The challenge of the microenvironment in B-cell lymphomas. Histopathology. 58:69–80. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Efstathiou E, Troncoso P, Wen S, Do KA, Pettaway CA, Pisters LL, McDonnell TJ and Logothetis CJ: Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer. Clin Cancer Res. 13:1224–1231. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Funahashi Y, Okamoto K, Adachi Y, Semba T, Uesugi M, Ozawa Y, Tohyama O, Uehara T, Kimura T, Watanabe H, et al: Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models. Cancer Sci. 105:1334–1342. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Zhu Y, Li F, Vadakkan TJ, Zhang M, Landua J, Wei W, Ma J, Dickinson ME, Rosen JM and Lewis MT: Three-dimensional vasculature reconstruction of tumour microenvironment via local clustering and classification. Interface Focus. 3:201300152013. View Article : Google Scholar : PubMed/NCBI

37 

Gavalas NG, Liontos M, Trachana SP, Bagratuni T, Arapinis C, Liacos C, Dimopoulos MA and Bamias A: Angiogenesis-related pathways in the pathogenesis of ovarian cancer. Int J Mol Sci. 14:15885–15909. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu JY, Yu D and Wu YH: Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review. Oncol Lett 15: 4427-4431, 2018.
APA
Hu, J., Yu, D., & Wu, Y. (2018). Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review. Oncology Letters, 15, 4427-4431. https://doi.org/10.3892/ol.2018.7895
MLA
Hu, J., Yu, D., Wu, Y."Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review". Oncology Letters 15.4 (2018): 4427-4431.
Chicago
Hu, J., Yu, D., Wu, Y."Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review". Oncology Letters 15, no. 4 (2018): 4427-4431. https://doi.org/10.3892/ol.2018.7895
Copy and paste a formatted citation
x
Spandidos Publications style
Hu JY, Yu D and Wu YH: Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review. Oncol Lett 15: 4427-4431, 2018.
APA
Hu, J., Yu, D., & Wu, Y. (2018). Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review. Oncology Letters, 15, 4427-4431. https://doi.org/10.3892/ol.2018.7895
MLA
Hu, J., Yu, D., Wu, Y."Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review". Oncology Letters 15.4 (2018): 4427-4431.
Chicago
Hu, J., Yu, D., Wu, Y."Primary non‑Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review". Oncology Letters 15, no. 4 (2018): 4427-4431. https://doi.org/10.3892/ol.2018.7895
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