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Article

In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system

  • Authors:
    • Ali Hafez Ali Mohammed El‑Far
    • Seiichi Munesue
    • Ai Harashima
    • Akira Sato
    • Mika Shindo
    • Shingo Nakajima
    • Mana Inada
    • Mariko Tanaka
    • Akihiko Takeuchi
    • Hiroyuki Tsuchiya
    • Hiroshi Yamamoto
    • Hazem M.E. Shaheen
    • Yasser S. El‑Sayed
    • Shuhei Kawano
    • Sei‑Ichi Tanuma
    • Yasuhiko Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920‑8640, Japan, Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278‑8510, Japan, Department of Orthopedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920‑8641, Japan, Department of Pharmacology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt, Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt
  • Pages: 4627-4634
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7902
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Abstract

Receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized‑peptide strategy drug design system. Papaverine significantly inhibited RAGE‑dependent nuclear factor κ‑B activation driven by high mobility group box‑1, a RAGE ligand. Using RAGE‑ or dominant‑negative RAGE‑expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE‑dependent cell proliferation and migration dose‑dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
El‑Far AH, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Tsuchiya H, et al: In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. Oncol Lett 15: 4627-4634, 2018.
APA
El‑Far, A.H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S. ... Yamamoto, Y. (2018). In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. Oncology Letters, 15, 4627-4634. https://doi.org/10.3892/ol.2018.7902
MLA
El‑Far, A. H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S., Inada, M., Tanaka, M., Takeuchi, A., Tsuchiya, H., Yamamoto, H., Shaheen, H. M., El‑Sayed, Y. S., Kawano, S., Tanuma, S., Yamamoto, Y."In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system". Oncology Letters 15.4 (2018): 4627-4634.
Chicago
El‑Far, A. H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S., Inada, M., Tanaka, M., Takeuchi, A., Tsuchiya, H., Yamamoto, H., Shaheen, H. M., El‑Sayed, Y. S., Kawano, S., Tanuma, S., Yamamoto, Y."In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system". Oncology Letters 15, no. 4 (2018): 4627-4634. https://doi.org/10.3892/ol.2018.7902
Copy and paste a formatted citation
x
Spandidos Publications style
El‑Far AH, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Tsuchiya H, et al: In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. Oncol Lett 15: 4627-4634, 2018.
APA
El‑Far, A.H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S. ... Yamamoto, Y. (2018). In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. Oncology Letters, 15, 4627-4634. https://doi.org/10.3892/ol.2018.7902
MLA
El‑Far, A. H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S., Inada, M., Tanaka, M., Takeuchi, A., Tsuchiya, H., Yamamoto, H., Shaheen, H. M., El‑Sayed, Y. S., Kawano, S., Tanuma, S., Yamamoto, Y."In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system". Oncology Letters 15.4 (2018): 4627-4634.
Chicago
El‑Far, A. H., Munesue, S., Harashima, A., Sato, A., Shindo, M., Nakajima, S., Inada, M., Tanaka, M., Takeuchi, A., Tsuchiya, H., Yamamoto, H., Shaheen, H. M., El‑Sayed, Y. S., Kawano, S., Tanuma, S., Yamamoto, Y."In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system". Oncology Letters 15, no. 4 (2018): 4627-4634. https://doi.org/10.3892/ol.2018.7902
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