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Article Open Access

NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

  • Authors:
    • Hairong Fu
    • Xiaoshan Li
    • Jiahua Tan
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China, Department of Pathology, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China, Department of Physical Education, Chongqing Three Gorges Medical College, Chongqing 404120, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4827-4836
    |
    Published online on: February 1, 2018
       https://doi.org/10.3892/ol.2018.7922
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Abstract

The main method for the treatment of acute myocardial infarction (AMI) is percutaneous coronary intervention; however percutaneous coronary intervention will induce ischemia/reperfusion (IR) injury, resulting in the loss of cardiac function and cardiomyocyte death. An effective drug to target this condition is necessary. N‑isopropylacrylamide and methacrylic acid were used to synthesize drug delivery nanoparticles (NP) containing the natural compound visnagin for IR injury treatment. It was demonstrated that NP containing fluorescein isothiocyanate localized to the site of myocardial IR, and that NP‑visnagin treatment induced cardioprotection, reducing the size of the MI and ameliorating cardiac dysfunction through the induction of autophagy and the inhibition of apoptosis. In the future, visnagin may be suitable as a drug for IR injury treatment, and NP may be an effective drug delivery system.
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1 

Capodanno D: Long-term EXAMINATION of drug-eluting stents in acute myocardial infarction. Lancet. 387:316–318. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Doll JA and Roe MT: Time to treatment as a quality metric for acute STEMI care. Lancet. 385:1056–1057. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Inoue T: Ischemia-reperfusion injury is still a big hurdle to overcome for treatment of acute myocardial infarction. J Cardiol. 67:305–306. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Kaul B and Staba EJ: Visnagin: Biosynthesis and isolation from ammi visnagi suspension cultures. Science. 150:1731–1732. 1995. View Article : Google Scholar

5 

Liu Y, Asnani A, Zou L, Bentley VL, Yu M, Wang Y, Dellaire G, Sarkar KS, Dai M, Chen HH, et al: Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Sci Transl Med. 6:266ra1702014. View Article : Google Scholar : PubMed/NCBI

6 

Abu-Hashem AA and El-Shazly M: Synthesis, reactions and biological activities of furochromones: A review. Eur J Med Chem. 90:633–665. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Hu CM, Fang RH, Luk BT and Zhang L: Nanoparticle-detained toxins for safe and effective vaccination. Nat Nanotechnol. 8:933–938. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Bearat HH, Lee BH and Vernon BL: Comparison of properties between NIPAAm-based simultaneously physically and chemically gelling polymer systems for use in vivo. Acta Biomater. 8:3629–3642. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Chao TI, Xiang S, Lipstate JF, Wang C and Lu J: Poly(methacrylic acid)-grafted carbon nanotube scaffolds enhance differentiation of hESCs into neuronal cells. Adv Mater. 22:3542–3547. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Zeighamian V, Darabi M, Akbarzadeh A, Rahmati-Yamchi M, Zarghami N, Badrzadeh F, Salehi R, Mirakabad FS and Taheri-Anganeh M: PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells. Artif Cells Nanomed Biotechnol. 44:735–742. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kim SW, Oh KT, Youn YS and Lee ES: Hyaluronated nanoparticles with pH- and enzyme-responsive drug release properties. Colloids Surf B Biointerfaces. 116:359–64. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Boateng S and Sanborn T: Acute myocardial infarction. Dis Mon. 59:83–96. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr, Gottlieb RA and Przyklenk K: Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation. 122:S179–S184. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Przyklenk K, Undyala VV, Wider J, Sala-Mercado JA, Gottlieb RA and Mentzer RM Jr: Acute induction of autophagy as a novel strategy for cardioprotection: Getting to the heart of the matter. Autophagy. 7:432–433. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hirsch A, Windhausen F, Tijssen JG, Verheugt FW, Cornel JH and de Winter RJ: Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): A follow-up study. Lancet. 369:827–835. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Takahama H, Minamino T, Asanuma H, Fujita M, Asai T, Wakeno M, Sasaki H, Kikuchi H, Hashimoto K, Oku N, et al: Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats. J Am Coll Cardiol. 53:709–717. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Cabigas EB, Ding G, Chen T, Saafir TB, Pendergrass KD, Wagner MB and Davis ME: Age- and chamber-specific differences in oxidative stress after ischemic injury. Pediatr Cardiol. 33:322–331. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Ragab FA, Hassan GS, Yossef HA and Hashem HA: Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents. Eur J Med Chem. 42:1117–1127. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Badr JM, Hadad GM, Nahriry K and Hassanean HA: Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. Nat Prod Res. 29:593–601. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kwon MS, Lee JK, Park SH, Sim YB, Jung JS, Won MH, Kim SM and Suh HW: Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus. Korean J Physiol Pharmacol. 14:257–263. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Lee JK, Jung JS, Park SH, Park SH, Sim YB, Kim SM, Ha TS and Suh HW: Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells. Arch Pharm Res. 33:1843–1850. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Vrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z and Haarmann-Stemmann T: Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 8:e749172013. View Article : Google Scholar : PubMed/NCBI

23 

Gatica D, Chiong M, Lavandero S and Klionsky DJ: Molecular mechanisms of autophagy in the cardiovascular system. Circ Res. 116:456–467. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Dutta D, Calvani R, Bernabei R, Leeuwenburgh C and Marzetti E: Contribution of impaired mitochondrial autophagy to cardiac aging: Mechanisms and therapeutic opportunities. Circ Res. 110:1125–1138. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Kolwicz SC Jr, Purohit S and Tian R: Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 113:603–616. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Nishida K, Yamaguchi O and Otsu K: Crosstalk between autophagy and apoptosis in heart disease. Circ Res. 103:343–351. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Kolwicz SC Jr, Purohit S and Tian R: Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 113:603–616. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Viola HM, Arthur PG and Hool LC: Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes. Circ Res. 100:1036–1044. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Dong S, Wang H, Tao S and Kiyama R: Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors. Environ Pollut. 213:809–824. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Ni HM, Bhakta A, Wang S, Li Z, Manley S, Huang H, Copple B and Ding WX: Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS One. 9:e1158492014. View Article : Google Scholar : PubMed/NCBI

31 

Farrall AL and Whitelaw ML: The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene. 28:3671–3680. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Vilahur G, Cubedo J, Casani L, Padro T, Sabate-Tenas M, Badimon JJ and Badimon L: Reperfusion-triggered stress protein response in the myocardium is blocked by post-conditioning. Systems biology pathway analysis highlights the key role of the canonical aryl-hydrocarbon receptor pathway. Eur Heart J. 34:2082–2093. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P and Li S: Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 198:103–114. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu H, Li X and Tan J: NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. Oncol Lett 15: 4827-4836, 2018.
APA
Fu, H., Li, X., & Tan, J. (2018). NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. Oncology Letters, 15, 4827-4836. https://doi.org/10.3892/ol.2018.7922
MLA
Fu, H., Li, X., Tan, J."NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis". Oncology Letters 15.4 (2018): 4827-4836.
Chicago
Fu, H., Li, X., Tan, J."NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis". Oncology Letters 15, no. 4 (2018): 4827-4836. https://doi.org/10.3892/ol.2018.7922
Copy and paste a formatted citation
x
Spandidos Publications style
Fu H, Li X and Tan J: NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. Oncol Lett 15: 4827-4836, 2018.
APA
Fu, H., Li, X., & Tan, J. (2018). NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis. Oncology Letters, 15, 4827-4836. https://doi.org/10.3892/ol.2018.7922
MLA
Fu, H., Li, X., Tan, J."NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis". Oncology Letters 15.4 (2018): 4827-4836.
Chicago
Fu, H., Li, X., Tan, J."NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis". Oncology Letters 15, no. 4 (2018): 4827-4836. https://doi.org/10.3892/ol.2018.7922
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