Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch

  • Authors:
    • Songcheng Yu
    • Zhen Yan
    • Feifei Feng
    • Jing Ni
    • Wei Wang
    • Kadijatu Nabie
    • Yiguo Zhang
    • Lingbo Qu
    • Yongjun Wu
  • View Affiliations / Copyright

    Affiliations: College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, College of Medical Bioengineering and Faculty of Life Sciences, University of Chongqing, Chongqing 400044, P.R. China, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
  • Pages: 5143-5148
    |
    Published online on: February 1, 2018
       https://doi.org/10.3892/ol.2018.7924
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Coal tar pitch (CTP) is a key factor in the development of occupational lung cancer. In order to investigate the function of the anti‑oxidative signaling pathway regulated by NF‑E2‑related factor 2 (Nrf2) during cancer development, BEAS‑2B cells were cultured with CTP extract for 30 passages. It was revealed that malignant transformation occurred in cells between the 20 and 30th passage. The expression levels of Nrf2 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were promoted throughout the CTP exposure culture, and there was a positive linear correlation between the expression levels of Nrf2 and NQO1. Following knockdown of Nrf2 expression, the level of NQO1 decreased markedly and malignant transformation was more likely to occur. It was hypothesized that CTP may be toxic to BEAS‑2B cells, which may lead to malignant transformation. Nrf2 was a quick response factor: Counteracting cytotoxicity by promoting the expression of anti‑oxidative genes. Thus, Nrf2 was associated with the malignant transformation of BEAS‑2B cells exposed to CTP and may be a potential therapeutic target.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Gibbs GW and Labrèche F: Cancer risks in aluminum reduction plant workers: A review. J Occup Environ Med. 56 5 Suppl:S40–S59. 2014. View Article : Google Scholar

2 

Kim SY, Lee J, Kim BH, Kim YJ, Yang KS and Park MS: Facile synthesis of carbon-coated silicon/graphite spherical composites for high-performance lithium-ion batteries. ACS Appl Mater Interfaces. 8:12109–12117. 2016. View Article : Google Scholar

3 

Yamaoka M, Asami SS, Funaki N, Kimura S, Yingjie L, Fukuda T and Yamashita M: Preparation of organic light-emitting diode using coal tar pitch, a low-cost material, for printable devices. PLoS One. 8:e629032013. View Article : Google Scholar

4 

Koganti A, Singh R, Rozett K, Modi N, Goldstein LS, Roy TA, Zhang FJ, Harvey RG and Weyand EH: 7H-benzo[c]fluorene: A major DNA adduct-forming component of coal tar. Carcinogenesis. 21:1601–1609. 2000. View Article : Google Scholar

5 

Lavoué J, Gérin M, Côté J and Lapointe R: Mortality and cancer experience of Quebec aluminum reduction plant workers. Part I: The reduction plants and coal tar pitch volatile (CTPV) exposure assessment. J Occup Environ Med. 49:997–1008. 2007. View Article : Google Scholar

6 

Spinelli JJ, Demers PA, Le ND, Friesen MD, Lorenzi MF, Fang R and Gallagher RP: Cancer risk in aluminum reduction plant workers (Canada). Cancer Causes Control. 17:939–948. 2006. View Article : Google Scholar

7 

Bolliet C, Juery C and Thiebaut B: Impact of oxidation process on polycyclic aromatic hydrocarbon (PAH) content in bitumen. J Occup Environ Hyg. 10:435–445. 2013. View Article : Google Scholar

8 

Feng F, Wu Y, Zhang S, Liu Y, Qin L, Wu Y, Yan Z and Wu W: Macrophages facilitate coal tar pitch extract-induced tumorigenic transformation of human bronchial epithelial cells mediated by NF-kB. PLoS One. 7:e516902012. View Article : Google Scholar

9 

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. 2007. View Article : Google Scholar

10 

Pilger A and Rudiger HW: 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health. 80:1–15. 2006. View Article : Google Scholar

11 

Taguchi K, Motohashi H and Yamamoto M: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells. 16:123–140. 2011. View Article : Google Scholar

12 

Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G and Dennery PA: Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses. J Biol Chem. 289:26882–26894. 2014. View Article : Google Scholar

13 

Ma Q: Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53:401–426. 2013. View Article : Google Scholar

14 

Li LR, Dong H, Song E, Xu X, Liu L and Song Y: Nrf2/ARE pathway activation, HO-1 and NQ01 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Chem Biol Interact. 209:56–67. 2014. View Article : Google Scholar

15 

Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO and El-Kadi AO: Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radic Biol Med. 67:171–187. 2014. View Article : Google Scholar

16 

Nioi P and Hayes JD: Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res. 555:149–171. 2004. View Article : Google Scholar

17 

Oh ET and Park HJ: Implications of NQO1 in cancer therapy. BMB Rep. 48:609–617. 2015. View Article : Google Scholar

18 

National Center for Biotechnology Information. https://www.ncbi.nlm.nih.govJanuary. 2018

19 

Feed ingredients for laboratory animal, National standard in China, GB 14924.3. 2010

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH and Kong AN: Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem. 275:39907–39913. 2000. View Article : Google Scholar

22 

Feng FF, Qin LJ, Wu YJ, Li YQ and Wu YM: GC-MS analysis of coal tar pitch fume exract. Ind Health Occup Dis. 37:198–203. 2011.(In Chinese).

23 

Moorthy B, Chu C and Carlin DJ: Polycyclic aromatic hydrocarbons: From metabolism to lung cancer. Toxicol Sci. 145:5–15. 2015. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu S, Yan Z, Feng F, Ni J, Wang W, Nabie K, Zhang Y, Qu L and Wu Y: NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch. Oncol Lett 15: 5143-5148, 2018.
APA
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K. ... Wu, Y. (2018). NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch. Oncology Letters, 15, 5143-5148. https://doi.org/10.3892/ol.2018.7924
MLA
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K., Zhang, Y., Qu, L., Wu, Y."NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch". Oncology Letters 15.4 (2018): 5143-5148.
Chicago
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K., Zhang, Y., Qu, L., Wu, Y."NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch". Oncology Letters 15, no. 4 (2018): 5143-5148. https://doi.org/10.3892/ol.2018.7924
Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Yan Z, Feng F, Ni J, Wang W, Nabie K, Zhang Y, Qu L and Wu Y: NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch. Oncol Lett 15: 5143-5148, 2018.
APA
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K. ... Wu, Y. (2018). NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch. Oncology Letters, 15, 5143-5148. https://doi.org/10.3892/ol.2018.7924
MLA
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K., Zhang, Y., Qu, L., Wu, Y."NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch". Oncology Letters 15.4 (2018): 5143-5148.
Chicago
Yu, S., Yan, Z., Feng, F., Ni, J., Wang, W., Nabie, K., Zhang, Y., Qu, L., Wu, Y."NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch". Oncology Letters 15, no. 4 (2018): 5143-5148. https://doi.org/10.3892/ol.2018.7924
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team