|
1
|
Jemal A, Bray F, Center MM, Ferlay J, Ward
E and Forman D: Global cancer statistics. CA Cancer J Clin.
61:69–90. 2011. View Article : Google Scholar
|
|
2
|
Heldin CH and Moustakas A: Role of Smads
in TGFβ signaling. Cell Tissue Res. 347:21–36. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Kretzschmar M, Doody J, Timokhina I and
Massagué J: A mechanism of repression of TGFbeta/Smad signaling by
oncogenic Ras. Genes Dev. 13:804–816. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Tahashi Y, Matsuzaki K, Date M, Yoshida K,
Furukawa F, Sugano Y, Matsushita M, Himeno Y, Inagaki Y and Inoue
K: Differential regulation of TGF-beta signal in hepatic stellate
cells between acute and chronic rat liver injury. Hepatology.
35:49–61. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Derynck R and Zhang YE: Smad-dependent and
Smad-independent pathways in TGF-beta family signalling. Nature.
425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Matsuzaki K, Murata M, Yoshida K, Sekimoto
G, Uemura Y, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M,
Fujisawa J, et al: Chronic inflammation associated with hepatitis C
virus infection perturbs hepatic transforming growth factor beta
signaling, promoting cirrhosis and hepatocellular carcinoma.
Hepatology. 46:48–57. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Freytag J, Wilkins-Port CE, Higgins CE,
Higgins SP, Samarakoon R and Higgins PJ: PAI-1 mediates the
TGF-beta1+EGF-induced ‘scatter’ response in transformed human
keratinocytes. J Invest Dermatol. 130:2179–2190. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wrighton KH, Willis D, Long J, Liu F, Lin
X and Feng XH: Small C-terminal domain phosphatases dephosphorylate
the regulatory linker regions of Smad2 and Smad3 to enhance
transforming growth factor-beta signaling. J Biol Chem.
281:38365–38375. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Javelaud D and Mauviel A: Crosstalk
mechanisms between the mitogen-activated protein kinase pathways
and Smad signaling downstream of TGF-beta: Implications for
carcinogenesis. Oncogene. 24:5742–5750. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Janda E, Lehmann K, Killisch I, Jechlinger
M, Herzig M, Downward J, Beug H and Grünert S: Ras and TGF[beta]
cooperatively regulate epithelial cell plasticity and metastasis:
Dissection of Ras signaling pathways. J Cell Biol. 156:299–313.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kfir S, Ehrlich M, Goldshmid A, Liu X,
Kloog Y and Henis YI: Pathway- and expression level-dependent
effects of oncogenic N-Ras: p27(Kip1) mislocalization by the
Ral-GEF pathway and Erk-mediated interference with Smad signaling.
Mol Cell Biol. 25:8239–8250. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Iwayama H, Sakamoto T, Nawa A and Ueda N:
Crosstalk between smad and mitogen-activated protein kinases for
the regulation of apoptosis in cyclosporine a-induced renal tubular
injury. Nephron Extra. 1:178–189. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Liu Q, Zhang Y, Mao H, Chen W, Luo N, Zhou
Q, Chen W and Yu X: A crosstalk between the Smad and JNK signaling
in the TGF-β-induced epithelial-mesenchymal transition in rat
peritoneal mesothelial cells. PLoS One. 7:e320092012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang FM, Hu T and Zhou X: p38
mitogen-activated protein kinase and alkaline phosphatase in human
dental pulp cells. Oral Surg Oral Med Oral Pathol Oral Radiol
Endod. 102:114–118. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Furukawa F, Matsuzaki K, Mori S, Tahashi
Y, Yoshida K, Sugano Y, Yamagata H, Matsushita M, Seki T, Inagaki
Y, et al: p38 MAPK mediates fibrogenic signal through Smad3
phosphorylation in rat myofibroblasts. Hepatology. 38:879–889.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Abécassis L, Rogier E, Vazquez A, Atfi A
and Bourgeade MF: Evidence for a role of MSK1 in transforming
growth factor-beta-mediated responses through p38alpha and Smad
signaling pathways. J Biol Chem. 279:30474–30479. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
He S, Liu X, Yang Y, Huang W, Xu S, Yang
S, Zhang X and Roberts MS: Mechanisms of transforming growth factor
beta(1)/Smad signalling mediated by mitogen-activated protein
kinase pathways in keloid fibroblasts. Br J Dermatol. 162:538–546.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Boye A, Kan H, Wu C, Jiang Y, Yang X, He S
and Yang Y: MAPK inhibitors differently modulate TGF-β/Smad
signaling in HepG2 cells. Tumour Biol. 36:3643–3651. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hill CS: Nucleocytoplasmic shuttling of
Smad proteins. Cell Res. 19:36–46. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Xu L, Yao X, Chen X, Lu P, Zhang B and Ip
YT: Msk is required for nuclear import of TGF-{beta}/BMP-activated
Smads. J Cell Biol. 178:981–994. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yao X, Chen X, Cottonham C and Xu L:
Preferential utilization of Imp7/8 in nuclear import of Smads. J
Biol Chem. 283:22867–22874. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Matsuzaki K: Smad phospho-isoforms direct
context-dependent TGF-β signaling. Cytokine Growth Factor Rev.
24:385–399. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Murata M, Matsuzaki K, Yoshida K, Sekimoto
G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, et
al: Hepatitis B virus X protein shifts human hepatic transforming
growth factor (TGF)-beta signaling from tumor suppression to
oncogenesis in early chronic hepatitis B. Hepatology. 49:1203–1217.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Nagata H, Hatano E, Tada M, Murata M,
Kitamura K, Asechi H, Narita M, Yanagida A, Tamaki N, Yagi S, et
al: Inhibition of c-Jun NH2-terminal kinase switches Smad3
signaling from oncogenesis to tumor-suppression in rat
hepatocellular carcinoma. Hepatology. 49:1944–1953. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kawamata S, Matsuzaki K, Murata M, Seki T,
Matsuoka K, Iwao Y, Hibi T and Okazaki K: Oncogenic Smad3 signaling
induced by chronic inflammation is an early event in ulcerative
colitis-associated carcinogenesis. Inflamm Bowel Dis. 17:683–695.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Velden JL, Alcorn JF, Guala AS, Badura EC
and Janssen-Heininger YM: c-Jun N-terminal kinase 1 promotes
transforming growth factor-β1-induced epithelial-to-mesenchymal
transition via control of linker phosphorylation and
transcriptional activity of Smad3. Am J Respir Cell Mol Biol.
44:571–581. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sekimoto G, Matsuzaki K, Yoshida K, Mori
S, Murata M, Seki T, Matsui H, Fujisawa J and Okazaki K: Reversible
Smad-dependent signaling between tumor suppression and oncogenesis.
Cancer Res. 67:5090–5096. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Hough C, Radu M and Doré JJ: Tgf-beta
induced Erk phosphorylation of smad linker region regulates smad
signaling. PLoS One. 7:e425132012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Mori S, Matsuzaki K, Yoshida K, Furukawa
F, Tahashi Y, Yamagata H, Sekimoto G, Seki T, Matsui H, Nishizawa
M, et al: TGF-beta and HGF transmit the signals through
JNK-dependent Smad2/3 phosphorylation at the linker regions.
Oncogene. 23:7416–7429. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Matsuzaki K, Kitano C, Murata M, Sekimoto
G, Yoshida K, Uemura Y, Seki T, Taketani S, Fujisawa J and Okazaki
K: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal
regions transmit malignant TGF-beta signal in later stages of human
colorectal cancer. Cancer Res. 69:5321–5330. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
De Bosscher K, Hill CS and Nicolás FJ:
Molecular and functional consequences of Smad4 C-terminal missense
mutations in colorectal tumour cells. Biochem J. 379:209–216. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chen HB, Rud JG, Lin K and Xu L: Nuclear
targeting of transforming growth factor-beta-activated Smad
complexes. J Biol Chem. 280:21329–21336. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Reguly T and Wrana JL: In or out? The
dynamics of Smad nucleocytoplasmic shuttling. Trends Cell Biol.
13:216–220. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Inman GJ, Nicolás FJ and Hill CS:
Nucleocytoplasmic shuttling of Smads 2, 3 and 4 permits sensing of
TGF-beta receptor activity. Mol Cell. 10:283–294. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Kurisaki A, Kose S, Yoneda Y, Heldin CH
and Moustakas A: Transforming growth factor-beta induces nuclear
import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol
Biol Cell. 12:1079–1091. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Schmierer B, Tournier AL, Bates PA and
Hill CS: Mathematical modeling identifies Smad nucleocytoplasmic
shuttling as a dynamic signal-interpreting system. Proc Natl Acad
Sci USA. 105:pp. 6608–6613. 2008; View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Zhang J, Ito H, Wate R, Ohnishi S, Nakano
S and Kusaka H: Altered distributions of nucleocytoplasmic
transport-related proteins in the spinal cord of a mouse model of
amyotrophic lateral sclerosis. Acta Neuropathol. 112:673–680. 2006.
View Article : Google Scholar : PubMed/NCBI
|
