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Article

Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer

  • Authors:
    • Xinghua Wei
    • Weiwei Zeng
    • Keji Xie
    • Pengfei Diao
    • Ping Tang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Urology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China
  • Pages: 5149-5154
    |
    Published online on: February 2, 2018
       https://doi.org/10.3892/ol.2018.7936
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Abstract

Although it is the most widely used biomarker for prostate cancer, the use of prostate specific antigen (PSA) is controversial due to its limitations in specificity and sensitivity. The proteasome is a complex associated with cell proliferation and apoptosis, and the abnormity of these processes may lead to tumor occurrence. Previous studies have reported that proteasomal activity is associated with cancer progression and can be used in risk stratification. The purpose of the present study was thus to investigate the feasibility of proteasome activity as a biomarker for prostate cancer. Proteasome activity in vitro and in vivo was detected, along with the expression of the substrate proteins NF‑κB inhibitor‑α (IκB‑α), Bcl-2‑associated X (Bax) and p27. Chymotrypsin‑like proteasomal activity was elevated by 70% in vitro and 23% in vivo, and the expression levels of the proteasome substrate proteins IκB‑α, Bax and p27 were decreased in prostate cancer cells and prostate tumor xenografts compared with normal mouse prostate tissue. In conclusion, proteasomal chymotrypsin‑like activity maybe a potential biomarker for prostate cancer, and may be suitable to supplement PSA in clinical application for prostate cancer diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wei X, Zeng W, Xie K, Diao P and Tang P: Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer. Oncol Lett 15: 5149-5154, 2018.
APA
Wei, X., Zeng, W., Xie, K., Diao, P., & Tang, P. (2018). Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer. Oncology Letters, 15, 5149-5154. https://doi.org/10.3892/ol.2018.7936
MLA
Wei, X., Zeng, W., Xie, K., Diao, P., Tang, P."Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer". Oncology Letters 15.4 (2018): 5149-5154.
Chicago
Wei, X., Zeng, W., Xie, K., Diao, P., Tang, P."Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer". Oncology Letters 15, no. 4 (2018): 5149-5154. https://doi.org/10.3892/ol.2018.7936
Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Zeng W, Xie K, Diao P and Tang P: Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer. Oncol Lett 15: 5149-5154, 2018.
APA
Wei, X., Zeng, W., Xie, K., Diao, P., & Tang, P. (2018). Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer. Oncology Letters, 15, 5149-5154. https://doi.org/10.3892/ol.2018.7936
MLA
Wei, X., Zeng, W., Xie, K., Diao, P., Tang, P."Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer". Oncology Letters 15.4 (2018): 5149-5154.
Chicago
Wei, X., Zeng, W., Xie, K., Diao, P., Tang, P."Potential use of chymotrypsin-like proteasomal activity as a biomarker for prostate cancer". Oncology Letters 15, no. 4 (2018): 5149-5154. https://doi.org/10.3892/ol.2018.7936
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