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Article

Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells

  • Authors:
    • Pei‑Hua Li
    • Lin Wang
    • Yao‑Jie Pan
    • Miao‑Miao Sang
    • Jun‑Nian Zheng
    • Dong‑Sheng Pei
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Rehabilitation Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Pathology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 5137-5142
    |
    Published online on: February 6, 2018
       https://doi.org/10.3892/ol.2018.7963
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Abstract

c-Jun activation domain-binding protein‑1 (Jab1) is a multifunctional protein involved in cell proliferation and apoptosis, DNA damage and repair and genome stability. In a number of types of human carcinoma, the abnormal expression of Jab1 is associated with poor prognosis, suggesting that Jab1 serves a vital function in tumorigenesis. However, the functional effects and the underlying molecular mechanisms of Jab1 in laryngeal squamous cell carcinoma (LSCC) progression remain poorly understood. The results of the present study demonstrate that downregulating Jab1 expression promotes LSCC apoptosis while inhibiting the proliferation of LSCC cells. Furthermore, Jab1 inhibition results in decreased protein kinase B phosphorylation accompanied by increased caspase‑3 cleavage and p53 expression. It has been identified that the increased expression of Jab1 is markedly associated with LSCC progression, therefore Jab1 may be used as a novel target for the treatment of laryngeal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li PH, Wang L, Pan YJ, Sang MM, Zheng JN and Pei DS: Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells. Oncol Lett 15: 5137-5142, 2018.
APA
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., & Pei, D. (2018). Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells. Oncology Letters, 15, 5137-5142. https://doi.org/10.3892/ol.2018.7963
MLA
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., Pei, D."Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells". Oncology Letters 15.4 (2018): 5137-5142.
Chicago
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., Pei, D."Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells". Oncology Letters 15, no. 4 (2018): 5137-5142. https://doi.org/10.3892/ol.2018.7963
Copy and paste a formatted citation
x
Spandidos Publications style
Li PH, Wang L, Pan YJ, Sang MM, Zheng JN and Pei DS: Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells. Oncol Lett 15: 5137-5142, 2018.
APA
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., & Pei, D. (2018). Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells. Oncology Letters, 15, 5137-5142. https://doi.org/10.3892/ol.2018.7963
MLA
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., Pei, D."Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells". Oncology Letters 15.4 (2018): 5137-5142.
Chicago
Li, P., Wang, L., Pan, Y., Sang, M., Zheng, J., Pei, D."Suppression of Jab1 expression inhibits proliferation and promotes apoptosis of AMC-HN-8 cells". Oncology Letters 15, no. 4 (2018): 5137-5142. https://doi.org/10.3892/ol.2018.7963
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