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Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer

  • Authors:
    • Ling Zhou
    • Min Wang
    • Chongyong Guo
    • Ying Zhu
    • Hua Yu
    • Lu Zhang
    • Pei Yu
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Branch of Shanghai First People's Hospital, Shanghai 200081, P.R. China, Department of Pathology, Branch of Shanghai First People's Hospital, Shanghai 200081, P.R. China, Department of General Surgery, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Orthopedics, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 210025, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4859-4866
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    Published online on: February 6, 2018
       https://doi.org/10.3892/ol.2018.7965
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Abstract

Over the past three decades, numerous patients with breast cancer succumbed to cancer metastasis and recurrence, while, the exact mechanisms underlying this malignancy, and the potential biomarkers for prognosis prediction remain elusive. It was previously demonstrated that phosphorylated RAC‑α serine/threonine‑protein kinase (pAkt) and Beclin 1 was associated with cancer metastasis, and recurrence. Thus far, the expression patterns of pAkt and Beclin 1 in breast cancer tissues, and their associations with the prognosis of invasive ductal breast cancer remain inconclusive, which may be due to various factors, including ethnicity and pathological types. In the present study, a total of 90 Chinese female patients with invasive ductal breast cancer between June 1999 and August 2002 were enrolled at Shanghai First People's Hospital (Shanghai, China). The patients were followed up from 5 months to 13.5 years for survival analysis. The expressional levels of pAkt and Beclin 1 in invasive ductal breast cancer tissues, and the normal paracancerous tissues were measured by immunohistochemistry. Associations with prognosis following surgery were further evaluated using Cox regression analysis. In 90 invasive ductal breast cancer samples, pAkt was detected in 17 (18.9%) samples and Beclin 1 in 33 (36.7%) samples, but both were not detected in any of the paracancerous samples. Survival analysis revealed that pAkt expression carried a tendency to predict a shorter disease-free survival (DFS) in patients with invasive ductal breast cancer. Additionally, Beclin 1 expression was not significantly associated with survival. Furthermore, univariate Cox regression analysis demonstrated that pAkt expression was negatively associated with DFS and overall survival. Multivariate Cox regression analysis indicated that pAkt expression was an independent risk factor associated with poor prognosis in patients with invasive ductal breast cancer (all P<0.05). pAkt may be used as a potential prognostic biomarker in Chinese women with invasive ductal breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou L, Wang M, Guo C, Zhu Y, Yu H, Zhang L and Yu P: Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer. Oncol Lett 15: 4859-4866, 2018.
APA
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., & Yu, P. (2018). Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer. Oncology Letters, 15, 4859-4866. https://doi.org/10.3892/ol.2018.7965
MLA
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., Yu, P."Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer". Oncology Letters 15.4 (2018): 4859-4866.
Chicago
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., Yu, P."Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer". Oncology Letters 15, no. 4 (2018): 4859-4866. https://doi.org/10.3892/ol.2018.7965
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou L, Wang M, Guo C, Zhu Y, Yu H, Zhang L and Yu P: Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer. Oncol Lett 15: 4859-4866, 2018.
APA
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., & Yu, P. (2018). Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer. Oncology Letters, 15, 4859-4866. https://doi.org/10.3892/ol.2018.7965
MLA
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., Yu, P."Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer". Oncology Letters 15.4 (2018): 4859-4866.
Chicago
Zhou, L., Wang, M., Guo, C., Zhu, Y., Yu, H., Zhang, L., Yu, P."Expression of pAkt is associated with a poor prognosis in Chinese women with invasive ductal breast cancer". Oncology Letters 15, no. 4 (2018): 4859-4866. https://doi.org/10.3892/ol.2018.7965
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