Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain

  • Authors:
    • Ying Wang
    • Chenyang Feng
    • Haoying He
    • Jinjin He
    • Jun Wang
    • Xiaomin Li
    • Shasha Wang
    • Wei Li
    • Jiuzhou Hou
    • Tong Liu
    • Dong Fang
    • Song‑Qiang Xie
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, P.R. China, Institute of Chemical Biology, College of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China, Department of Clinic Pharmacy, The First Affiliated Hospital of Henan University, Kaifeng, Henan 475001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5013-5019
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/ol.2018.7986
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Vincristine is one of the most common anticancer drugs clinically employed in the treatment of various malignancies. A major side effect associated with vincristine is the development of neuropathic pain, which is not readily relieved by available analgesics. Although efforts have been made to identify the pathogenesis of vincristine‑induced neuropathic pain, the mechanisms underlying its pathogenesis have not been fully elucidated. In the present study, a neuropathic pain model was established in Sprague‑Dawley rats by intraperitoneal injection of vincristine sulfate. The results demonstrated that vincristine administration induced the upregulation of transient receptor potential cation channel subfamily V member 1 (TRPV1) protein expression and current density in dorsal root ganglion (DRG) nociceptive neurons. Consistently, inhibition of TRPV1 with capsazepine alleviated vincristine‑induced mechanical allodynia and thermal hyperalgesia in rats. Furthermore, vincristine administration induced the upregulation of tumor necrosis factor (TNF)‑α production in DRGs, and inhibition of TNF‑α synthesis with thalidomide in vivo reversed TRPV1 protein expression, as well as pain hypersensitivity induced by vincristine in rats. The present results suggested that TNF‑α could sensitize TRPV1 by promoting its expression, thus leading to mechanical allodynia and thermal hyperalgesia in vincristine‑treated rats. Taken together, these findings may enhance our understanding of the pathophysiological mechanisms underlying vincristine‑induced pain.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Nieder C, Mehta MP and Jalali R: Combined radio- and chemotherapy of brain tumours in adult patients. Clin Oncol (R Coll Radiol). 21:515–524. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Raj TA, Smith AM and Moore AS: Vincristine sulfate liposomal injection for acute lymphoblastic leukemia. Int J Nanomedicine. 8:4361–4369. 2013.PubMed/NCBI

3 

Eden T, Pieters R and Richards S; Childhood Acute Lymphoblastic Leukaemia Collaborative Group (CALLCG), : Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia-an individual patient data meta-analysis involving 5,659 children. Br J Haematol. 149:722–733. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Quasthoff S and Hartung HP: Chemotherapy-induced peripheral neuropathy. J Neurol. 249:9–17. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Sioka C and Kyritsis AP: Central and peripheral nervous system toxicity of common chemotherapeutic agents. Cancer Chemother Pharmacol. 63:761–767. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Hu C, Zhao YT, Zhang G and Xu MF: Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain. Mol Med Rep. 15:975–980. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Allen DT and Kiernan JA: Permeation of proteins from the blood into peripheral nerves and ganglia. Neuroscience. 59:755–764. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Old EA, Nadkarni S, Grist J, Gentry C, Bevan S, Kim KW, Mogg AJ, Perretti M and Malcangio M: Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. J Clin Invest. 124:2023–2036. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Mitchell K, Bates BD, Keller JM, Lopez M, Scholl L, Navarro J, Madian N, Haspel G, Nemenov MI and Iadarola MJ: Ablation of rat TRPV1-expressing Adelta/C-fibers with resiniferatoxin: Analysis of withdrawal behaviors, recovery of function and molecular correlates. Mol Pain. 6:942010. View Article : Google Scholar : PubMed/NCBI

10 

Han Q, Kim YH, Wang X, Liu D, Zhang ZJ, Bey AL, Lay M, Chang W, Berta T, Zhang Y, et al: SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons. Neuron. 92:1279–1293. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Fang D, Kong LY, Cai J, Li S, Liu XD, Han JS and Xing GG: Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: Roles in the development of bone cancer pain in a rat model. Pain. 156:1124–1144. 2015.PubMed/NCBI

12 

Labuz D, Spahn V, Celik MÖ and Machelska H: Opioids and TRPV1 in the peripheral control of neuropathic pain-Defining a target site in the injured nerve. Neuropharmacology. 101:330–340. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Morales-Lázaro SL, Llorente I, Sierra-Ramírez F, López-Romero AE, Ortíz-Rentería M, Serrano-Flores B, Simon SA, Islas LD and Rosenbaum T: Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. Nat Commun. 7:130922016. View Article : Google Scholar : PubMed/NCBI

14 

Xiao X, Zhao XT, Xu LC, Yue LP, Liu FY, Cai J, Liao FF, Kong JG, Xing GG, Yi M and Wan Y: Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain. 156:597–608. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Xu Q, Zhang XM, Duan KZ, Gu XY, Han M, Liu BL, Zhao ZQ and Zhang YQ: Peripheral TGF-β1 signaling is a critical event in bone cancer-induced hyperalgesia in rodents. J Neurosci. 33:19099–19111. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Kiguchi N, Maeda T, Kobayashi Y, Saika F and Kishioka S: Involvement of inflammatory mediators in neuropathic pain caused by vincristine. Int Rev Neurobiol. 85:179–190. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Shen Y, Zhang ZJ, Zhu MD, Jiang BC, Yang T and Gao YJ: Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice. Neurobiol Dis. 79:100–110. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Constantin CE, Mair N, Sailer CA, Andratsch M, Xu ZZ, Blumer MJ, Scherbakov N, Davis JB, Bluethmann H, Ji RR and Kress M: Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci. 28:5072–5081. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Rozas P, Lazcano P, Piña R, Cho A, Terse A, Pertusa M, Madrid R, Gonzalez-Billault C, Kulkarni AB and Utreras E: Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons. Pain. 157:1346–1362. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Kahng J, Kim TK, Chung EY, Kim YS and Moon JY: The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model. J Int Med Res. 43:350–355. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Jiang H, Fang D, Kong LY, Jin ZR, Cai J, Kang XJ, Wan Y and Xing GG: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Mol Brain. 7:722014. View Article : Google Scholar : PubMed/NCBI

22 

Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 53:55–63. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Tyrrell L, Renganathan M, Dib-Hajj SD and Waxman SG: Glycosylation alters steady-state inactivation of sodium channel Nav1.9/NaN in dorsal root ganglion neurons and is developmentally regulated. J Neurosci. 21:9629–9637. 2001.PubMed/NCBI

24 

Chen Y, Zhang Y, Huo Y, Wang D and Hong Y: Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in rats. Brain Res. 1644:183–191. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Xu J.E.X..Liu H, Li F, Cao Y, Tian J and Yan J: Tumor necrosis factor-alpha is a potential diagnostic biomarker for chronic neuropathic pain after spinal cord injury. Neurosci Lett. 595:30–34. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Sisignano M, Baron R, Scholich K and Geisslinger G: Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nat Rev Neurol. 10:694–707. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Bosilkovska M, Ing Lorenzini K, Uppugunduri CR, Desmeules J, Daali Y and Escher M: Severe vincristine-induced neuropathic pain in a CYP3A5 nonexpressor with reduced CYP3A4/5 activity: Case study. Clin Ther. 38:216–220. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Gong SS, Li YX, Zhang MT, Du J, Ma PS, Yao WX, Zhou R, Niu Y, Sun T and Yu JQ: Neuroprotective effect of matrine in mouse model of vincristine-induced neuropathic pain. Neurochem Res. 41:3147–3159. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Walters ET: Neuroinflammatory contributions to pain after SCI: Roles for central glial mechanisms and nociceptor-mediated host defense. Exp Neurol. 258:48–61. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kochukov MY: Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. Mol Pain. 5:492009. View Article : Google Scholar : PubMed/NCBI

31 

Sacerdote P, Franchi S, Gerra G, Leccese V, Panerai AE and Somaini L: Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function. Brain Behav Immun. 22:606–613. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Sasaki M, Hashimoto S, Sawa T and Amaya F: Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury. Neuroscience. 279:1–9. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Liu J, Du J, Yang Y and Wang Y: Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 273:253–262. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Hensellek S, Brell P, Schaible HG, Bräuer R and Segond von Banchet G: The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 36:381–391. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Feng C, He H, He J, Wang J, Li X, Wang S, Li W, Hou J, Liu T, Liu T, et al: Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain. Oncol Lett 15: 5013-5019, 2018.
APA
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X. ... Xie, S. (2018). Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain. Oncology Letters, 15, 5013-5019. https://doi.org/10.3892/ol.2018.7986
MLA
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X., Wang, S., Li, W., Hou, J., Liu, T., Fang, D., Xie, S."Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain". Oncology Letters 15.4 (2018): 5013-5019.
Chicago
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X., Wang, S., Li, W., Hou, J., Liu, T., Fang, D., Xie, S."Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain". Oncology Letters 15, no. 4 (2018): 5013-5019. https://doi.org/10.3892/ol.2018.7986
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Feng C, He H, He J, Wang J, Li X, Wang S, Li W, Hou J, Liu T, Liu T, et al: Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain. Oncol Lett 15: 5013-5019, 2018.
APA
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X. ... Xie, S. (2018). Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain. Oncology Letters, 15, 5013-5019. https://doi.org/10.3892/ol.2018.7986
MLA
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X., Wang, S., Li, W., Hou, J., Liu, T., Fang, D., Xie, S."Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain". Oncology Letters 15.4 (2018): 5013-5019.
Chicago
Wang, Y., Feng, C., He, H., He, J., Wang, J., Li, X., Wang, S., Li, W., Hou, J., Liu, T., Fang, D., Xie, S."Sensitization of TRPV1 receptors by TNF‑α orchestrates the development of vincristine‑induced pain". Oncology Letters 15, no. 4 (2018): 5013-5019. https://doi.org/10.3892/ol.2018.7986
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team