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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2018 Volume 15 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood

  • Authors:
    • Weihuang Liu
    • Jie Zhao
    • Qiaoqi Li
    • Qiaona Wang
    • Ying Zhou
    • Zan Tong
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 5087-5092
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/ol.2018.7990
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Abstract

Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers in the peripheral blood, which are informative for gastric cancer stages, is not only useful for prognosis but may also provide mechanistic insights into processes facilitating therapy. The present study investigated plasmacytoid dendritic cells (pDCs) and myeloid CD1c+ dendritic cells (mDC1s) in the peripheral blood of patients with gastric cancer and healthy controls using flow cytometry. Using peripheral DC staining and subset analysis, patients with gastric cancer were identified to have substantially higher numbers of peripheral pDCs and mDC1s. In addition, there was a trend of elevated circulating pDCs with advanced stages and lymph node metastasis in gastric cancer, whereas no differences in circulating mDC1s were observed among the various groups. The results suggested that circulating pDCs are a positive prognostic indicator in patients with gastric cancer of different stages and highlighted the critical role of pDCs immunity in the development of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Zhao J, Li Q, Wang Q, Zhou Y and Tong Z: Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood. Oncol Lett 15: 5087-5092, 2018.
APA
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., & Tong, Z. (2018). Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood. Oncology Letters, 15, 5087-5092. https://doi.org/10.3892/ol.2018.7990
MLA
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., Tong, Z."Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood". Oncology Letters 15.4 (2018): 5087-5092.
Chicago
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., Tong, Z."Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood". Oncology Letters 15, no. 4 (2018): 5087-5092. https://doi.org/10.3892/ol.2018.7990
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zhao J, Li Q, Wang Q, Zhou Y and Tong Z: Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood. Oncol Lett 15: 5087-5092, 2018.
APA
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., & Tong, Z. (2018). Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood. Oncology Letters, 15, 5087-5092. https://doi.org/10.3892/ol.2018.7990
MLA
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., Tong, Z."Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood". Oncology Letters 15.4 (2018): 5087-5092.
Chicago
Liu, W., Zhao, J., Li, Q., Wang, Q., Zhou, Y., Tong, Z."Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood". Oncology Letters 15, no. 4 (2018): 5087-5092. https://doi.org/10.3892/ol.2018.7990
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