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Article Open Access

Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma

  • Authors:
    • Ge Bai
    • Mei Yang
    • Chao Zheng
    • Li Zhang
    • Mayinur Eli
  • View Affiliations / Copyright

    Affiliations: Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Autonomous Region 830011, P.R. China, VIP Medicine, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Autonomous Region 830011, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5703-5711
    |
    Published online on: February 8, 2018
       https://doi.org/10.3892/ol.2018.8004
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Abstract

Progestin and adipoQ receptor family member 3 (PAQR3) is a novel tumor suppressor; however, its function in esophageal cancer is not well understood. The present study explored the association between PAQR3, and the survival and clinical phenotype in patients with esophageal squamous cell carcinoma (ESCC). The expression of PAQR3 in 80 cases of ESCC and its corresponding adjacent tissues was detected by reverse transcription‑quantitative polymerase chain reaction. The results demonstrated that PAQR3 expression in cancer tissues was significantly lower compared with that in adjacent tissues. Clinicopathological analysis indicated that PAQR3 expression was significantly correlated with ethnicity (P=0.032), tumor length (P=0.019), lymph node metastasis (P=0.011) and local recurrence (P=0.009). Notably, the Kaplan‑Meier survival curve demonstrated that a decrease in PAQR3 expression was associated with poor prognosis in patients with ESCC. Multivariate analysis indicated that PAQR3 expression was an independent prognostic indicator for patients with ESCC. PAQR3 may serve an important role in the progress of ESCC and become a potential candidate for ESCC targeted therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Bai G, Yang M, Zheng C, Zhang L and Eli M: Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma. Oncol Lett 15: 5703-5711, 2018.
APA
Bai, G., Yang, M., Zheng, C., Zhang, L., & Eli, M. (2018). Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma. Oncology Letters, 15, 5703-5711. https://doi.org/10.3892/ol.2018.8004
MLA
Bai, G., Yang, M., Zheng, C., Zhang, L., Eli, M."Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma". Oncology Letters 15.4 (2018): 5703-5711.
Chicago
Bai, G., Yang, M., Zheng, C., Zhang, L., Eli, M."Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma". Oncology Letters 15, no. 4 (2018): 5703-5711. https://doi.org/10.3892/ol.2018.8004
Copy and paste a formatted citation
x
Spandidos Publications style
Bai G, Yang M, Zheng C, Zhang L and Eli M: Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma. Oncol Lett 15: 5703-5711, 2018.
APA
Bai, G., Yang, M., Zheng, C., Zhang, L., & Eli, M. (2018). Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma. Oncology Letters, 15, 5703-5711. https://doi.org/10.3892/ol.2018.8004
MLA
Bai, G., Yang, M., Zheng, C., Zhang, L., Eli, M."Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma". Oncology Letters 15.4 (2018): 5703-5711.
Chicago
Bai, G., Yang, M., Zheng, C., Zhang, L., Eli, M."Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma". Oncology Letters 15, no. 4 (2018): 5703-5711. https://doi.org/10.3892/ol.2018.8004
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