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Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof

  • Authors:
    • Qingliang Chen
    • Congmei Wang
    • Hongkai Zhang
    • Yun Li
    • Yunhong Cao
    • Yongxiang Zhang
    • Shaokun Liu
    • Zhen Li
    • Xiaoguo Xin
    • Xinwei Han
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Third People's Provincial Hospital of Henan Province, Zhengzhou, Henan 450006, P.R. China, Department of Radiology, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China, Department of Radiology, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China, Department of Radio-Intervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5947-5951
    |
    Published online on: February 9, 2018
       https://doi.org/10.3892/ol.2018.8016
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Abstract

This study aimed to investigate the expression levels of microRNA-195 (miRNA-195) in different types of patients with cholangiocarcinoma (CCA) and its correlation with the prognosis. Serum samples were collected from different types of patients with CCA (I, II, III, IV) and normal cases, followed by detection of expression of miRNA‑195 using quantitative polymerase chain reaction (qPCR). The serum samples of 204 patients with CCA, including 75 cases of type I, 68 cases of type II, 35 cases of type III and 26 cases of type IV and 200 healthy subjects were selected. The baseline clinicopathological data of patients with CCA were assessed and recorded, and patients were followed up constantly. The receiver operating characteristic (ROC) curve was established, and the area under the ROC curve (AUC) was calculated to evaluate the difference of miRNA-195 expression levels between patients with CCA and normal controls. Survival curves were set up for groups with high and low expression levels via the Kaplan‑Meier method, and the log-rank test was used to evaluate the difference of survival curves between the two groups. The expression of miR-195 in patients with CCA was significantly lower than that in the normal control group, with a sensitivity of 0.78 and a specificity of 0.76, and it was positively correlated with the pathological grade of CCA. Additionally, the expression level of serum miRNA‑195 was associated with lymph node metastasis (P=0.009) and tumor-node-metastasis (TNM) classification (P=0.010). The survival analysis revealed that the prognosis in patients with CCA in types III and IV was poorer than that in those with types I and III who had a low expression of miRNA-195 (P=0.0026). The results show that miR-195 is an important marker that reflects the malignant degree of CCA, and it is expected to be a reference marker to determine the prognosis of CCA.
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1 

Blechacz B: Cholangiocarcinoma: Current knowledge and new developments. Gut Liver. 11:13–26. 2017. View Article : Google Scholar

2 

Marcano-Bonilla L, Mohamed EA, Mounajjed T and Roberts LR: Biliary tract cancers: Epidemiology, molecular pathogenesis and genetic risk associations. Linchuang Zhongliuxue Zazhi. 5:612016.

3 

Razumilava N and Gores GJ: Cholangiocarcinoma. Lancet. 383:2168–2179. 2014. View Article : Google Scholar

4 

Fairweather M, Balachandran VP and D'Angelica MI: Surgical management of biliary tract cancers. Linchuang Zhongliuxue Zazhi. 5:632016.

5 

Høgdall D, O'Rourke CJ, Taranta A, Oliveira DV and Andersen JB: Molecular pathogenesis and current therapy in intrahepatic cholangiocarcinoma. Dig Dis. 34:440–451. 2016. View Article : Google Scholar

6 

Jiang XM, Li ZL, Li JL, Zheng WY, Li XH, Cui YF and Sun DJ: LncRNA CCAT1 as the unfavorable prognostic biomarker for cholangiocarcinoma. Eur Rev Med Pharmacol Sci. 21:1242–1247. 2017.

7 

Zen K and Zhang CY: Circulating microRNAs: A novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. 32:326–348. 2012. View Article : Google Scholar

8 

Luo Q, Wei C, Li X, Li J, Chen L, Huang Y, Song H, Li D and Fang L: MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer. Oncol Rep. 31:1096–1102. 2014. View Article : Google Scholar

9 

Yongchun Z, Linwei T, Xicai W, Lianhua Y, Guangqiang Z, Ming Y, Guanjian L, Yujie L and Yunchao H: MicroRNA-195 inhibits non-small cell lung cancer cell proliferation, migration and invasion by targeting MYB. Cancer Lett. 347:65–74. 2014. View Article : Google Scholar

10 

Heneghan HM, Miller N, Kelly R, Newell J and Kerin MJ: Systemic miRNA-195 differentiates breast cancer from other malignancies and is a potential biomarker for detecting noninvasive and early stage disease. Oncologist. 15:673–682. 2010. View Article : Google Scholar

11 

Eriksen AHM, Sørensen FB, Andersen RF, Jakobsen A and Hansen TF: Association between the expression of microRNAs and the response of patients with locally advanced rectal cancer to preoperative chemoradiotherapy. Oncol Lett. 14:201–209. 2017. View Article : Google Scholar

12 

Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, et al: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64:3753–3756. 2004. View Article : Google Scholar

13 

Forte S, La Rosa C, Pecce V, Rosignolo F and Memeo L: The role of microRNAs in thyroid carcinomas. Anticancer Res. 35:2037–2047. 2015.

14 

Letelier P, Riquelme I, Hernández AH, Guzmán N, Farías JG and Roa JC: Circulating MicroRNAs as biomarkers in biliary tract cancers. Int J Mol Sci. 17:172016. View Article : Google Scholar

15 

Ortiz-Quintero B: Cell-free microRNAs in blood and other body fluids, as cancer biomarkers. Cell Prolif. 49:281–303. 2016. View Article : Google Scholar

16 

Han K, Chen X, Bian N, Ma B, Yang T, Cai C, Fan Q, Zhou Y and Zhao TB: MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1. Oncotarget. 6:8875–8889. 2015. View Article : Google Scholar

17 

Soon PS, Tacon LJ, Gill AJ, Bambach CP, Sywak MS, Campbell PR, Yeh MW, Wong SG, Clifton-Bligh RJ, Robinson BG, et al: MiR-195 and miR-483-5p identified as predictors of poor prognosis in adrenocortical cancer. Clin Cancer Res. 15:7684–7692. 2009. View Article : Google Scholar

18 

Zanette DL, Rivadavia F, Molfetta GA, Barbuzano FG, Proto-Siqueira R, Silva-Jr WA, Falcão RP and Zago MA: miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res. 40:1435–1440. 2007. View Article : Google Scholar

19 

Hannafon BN, Sebastiani P, de las Morenas A, Lu J and Rosenberg CL: Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res. 13:R242011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Wang C, Zhang H, Li Y, Cao Y, Zhang Y, Liu S, Li Z, Xin X, Han X, Han X, et al: Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof. Oncol Lett 15: 5947-5951, 2018.
APA
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y. ... Han, X. (2018). Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof. Oncology Letters, 15, 5947-5951. https://doi.org/10.3892/ol.2018.8016
MLA
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y., Liu, S., Li, Z., Xin, X., Han, X."Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof". Oncology Letters 15.4 (2018): 5947-5951.
Chicago
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y., Liu, S., Li, Z., Xin, X., Han, X."Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof". Oncology Letters 15, no. 4 (2018): 5947-5951. https://doi.org/10.3892/ol.2018.8016
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Wang C, Zhang H, Li Y, Cao Y, Zhang Y, Liu S, Li Z, Xin X, Han X, Han X, et al: Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof. Oncol Lett 15: 5947-5951, 2018.
APA
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y. ... Han, X. (2018). Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof. Oncology Letters, 15, 5947-5951. https://doi.org/10.3892/ol.2018.8016
MLA
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y., Liu, S., Li, Z., Xin, X., Han, X."Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof". Oncology Letters 15.4 (2018): 5947-5951.
Chicago
Chen, Q., Wang, C., Zhang, H., Li, Y., Cao, Y., Zhang, Y., Liu, S., Li, Z., Xin, X., Han, X."Expression levels of serum miRNA-195 in different types of patients with cholangiocarcinoma and its value to determine the prognosis thereof". Oncology Letters 15, no. 4 (2018): 5947-5951. https://doi.org/10.3892/ol.2018.8016
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