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Article

MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor

  • Authors:
    • Jianqiao Luo
    • Caidan Zhu
    • Hongya Wang
    • Li Yu
    • Jianwei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Shaoxing Shangyu Women and Children Hospital, Shaoxing, Zhejiang 312000, P.R. China, Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 5803-5808
    |
    Published online on: February 12, 2018
       https://doi.org/10.3892/ol.2018.8025
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Abstract

Primary ovarian cancer is the main cause of gynecological cancer‑associated mortality. However, the mechanism behind the spread of ovarian cancer requires elucidation. The present study aimed to investigate the effects of microRNA‑126 (miR‑126) on differentiation and invasion, and its mechanism in primary ovarian cancer. Ovarian cancer SKOV3 cells transfected with LV3‑has‑miR‑126 mimics and LV3‑has‑miR‑126 inhibitor were produced; it was revealedthatLV‑miR‑126 mimics could induce cell cycle arrest at G1 phase, suppress cell invasion through Matrigel‑coated membranes and downregulate the expression of vascular endothelial growth factor (VEGF). Furthermore, LV‑has‑miR‑126 inhibitor‑transfected cells could increase the number of cells in S phase, induce cell invasion and upregulate the expression of VEGF. The present study, to the best of our knowledge, is the first to report that miR‑126 may serve tumor suppressor roles by inducing G1 cell cycle arrest and suppressing invasion in ovarian cancer cells, at least in part by targeting VEGF expression.
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Copy and paste a formatted citation
Spandidos Publications style
Luo J, Zhu C, Wang H, Yu L and Zhou J: MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncol Lett 15: 5803-5808, 2018.
APA
Luo, J., Zhu, C., Wang, H., Yu, L., & Zhou, J. (2018). MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncology Letters, 15, 5803-5808. https://doi.org/10.3892/ol.2018.8025
MLA
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15.4 (2018): 5803-5808.
Chicago
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15, no. 4 (2018): 5803-5808. https://doi.org/10.3892/ol.2018.8025
Copy and paste a formatted citation
x
Spandidos Publications style
Luo J, Zhu C, Wang H, Yu L and Zhou J: MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncol Lett 15: 5803-5808, 2018.
APA
Luo, J., Zhu, C., Wang, H., Yu, L., & Zhou, J. (2018). MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncology Letters, 15, 5803-5808. https://doi.org/10.3892/ol.2018.8025
MLA
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15.4 (2018): 5803-5808.
Chicago
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15, no. 4 (2018): 5803-5808. https://doi.org/10.3892/ol.2018.8025
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