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Article

Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells

  • Authors:
    • Chiawen Hsieh
    • Yun‑Wei Lin
    • Ching‑Hsein Chen
    • Wenjun Ku
    • Fuching Ma
    • Hanming Yu
    • Chishih Chu
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60004, Taiwan, R.O.C., Department of Biochemistry and Biotechnology Sciences, National Chiayi University, Chiayi 60004, Taiwan, R.O.C., Forest Chemistry Division, Taiwan Forestry Research Institute, Taipei 10066, Taiwan, R.O.C., Silviculture Division, Taiwan Forestry Research Institute, Taipei 10066, Taiwan, R.O.C., Fushan Botanic Garden, Taiwan Forestry Research Institute, Yuanshan, Yilan 26445, Taiwan, R.O.C.
  • Pages: 5915-5923
    |
    Published online on: February 14, 2018
       https://doi.org/10.3892/ol.2018.8052
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Abstract

Natural compounds have been candidates for anticancer medicine over the last 20 years. During the process of isolating seed oil from Calophyllum inophyllum L., yellow and green pigments containing multiple compounds with an aromatic structure were identified. High‑performance liquid chromatography and nuclear magnetic resonance analysis of these pigments revealed that the compounds present were identical, but the concentration of the compounds was different. Treatment with the pigments was able to induce the death of DLD‑1 human colon cancer cells and increase the percentage of the cells in the sub‑G1 and sub‑G2/M phases in a dose‑dependent manner. Additionally, the pigments were able to exhibit cytotoxic activity on A549 and H1975 human non‑small cell lung cancer (NSCLC) cell lines at 24 h, with half‑maximal inhibitory concentrations (IC50) values of 0.1206 and 0.0676%, respectively for green pigments, and 0.0434 and 0.0501%, respectively for yellow pigments. Furthermore, a decrease in IC50 value was associated with an increase in the duration of treatment. However, a sharp decrease in IC50 value of the yellow pigment was observed for H1975 cells at 48 h and for A549 cells at 72 h compared with no change in IC50 value for the green pigment with time, suggesting that the pigments function and induce cell death differently in the two cell lines. An investigation was performed into the synergistic effect of the green pigment and gefitinib (Iressa®, ZD1839), which is a selective epidermal growth factor receptor‑tyrosine kinase inhibitor to block growth factor‑mediated cell proliferation. The combination of the green pigment and gefitinib resulted in an enhancement of the decrease in viability of A549 and H1975 cells compared with treatment with gefitinib alone, which suggested that treatment with the green pigments was able to enhance the sensitivity of NSCLC cells to gefitinib. In conclusion, these pigments may be considered for development as anti‑colon cancer agents.
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1 

Prasad J, Shrivastava A, Khanna AK, Bhatia G, Awasthi SK and Narendera T: Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum. Phytomedicine. 19:1245–1249. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Tsai SC, Liang YH, Chiang JH, Liu FC, Lin WH, Chang SJ, Lin WY, Wu CH and Weng JR: Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells. Oncol Rep. 28:1096–1102. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Spino C, Dodier M and Sotheeswaran S: Anti-HIV coumarins from calophyllum seed oil. Bioorg Med Chem Lett. 8:3475–3478. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Venugopala KN, Rashmi V and Odhav B: Review on natural coumarin lead compounds for their pharmacological activity. Biomed Res Int. 2013:9632482013. View Article : Google Scholar : PubMed/NCBI

5 

Luo KW, Sun JG, Chan JY, Yang L, Wu SH, Fung KP and Liu FY: Anticancer effects of imperatorin isolated from Angelica dahurica: Induction of apoptosis in HepG2 cells through both death-receptor and mitochondria-mediated pathways. Chemotherapy. 57:449–459. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Yun ES, Park SS, Shin HC, Choi YH, Kim WJ and Moon SK: p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation. Toxicol In Vitro. 25:1335–1342. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yang D, Gu T, Wang T, Tang Q and Ma C: Effects of osthole on migration and invasion in breast cancer cells. Biosci Biotechnol Biochem. 74:1430–1434. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Itoigawa M, Ito C, Tan HT, Kuchide M, Tokuda H, Nishino H and Furukawa H: Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Lett. 169:15–19. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Cooper GM: The Development and Causes of Cancer. The Cell: A Molecular Approach. 2nd. Sinauer Associates; Sunderland, MA: 2000

10 

World Health Organization, . Cancer worldwide = World Cancer Report 2014. Stewart BW and Wild CP: IARC Nonserial Publication; pp. 16–81. 2014

11 

Parkinn DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

12 

World Health Organization, . GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Cancer fact sheets: Lung. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxDec 27–2013

13 

Dikshit R, Gupta PC, Ramasundarahettige C, Gajalakshmi V, Aleksandrowicz L, Badwe R, Kumar R, Roy S, Suraweera W, Bray F, et al: Cancer mortality in India: A nationally representative survey. Lancet. 379:1807–1816. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Earp HS, Dawson TL, Li X and Yu H: Heterodimerization and functional interaction between EGF receptor family members: A new signaling paradigm with implications for breast cancer research. Breast Cancer Res Treat. 35:115–132. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Yeh CH, Yang ST and Chen CH: Calvatia lilacina protein extract induces apoptosis through endoplasmic reticulum stress in human colon carcinoma cells. Process Biochem. 46:1599–1606. 2011. View Article : Google Scholar

16 

Chen CH, Lin WC, Kuo CN and Lu FJ: Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells. Food Chem Toxicol. 49:494–501. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Yang JT, Li ZL, Wu JY, Lu FJ and Chen CH: An oxidative stress mechanism of shikonin in human glioma cells. PLoS One. 9:e941802014. View Article : Google Scholar : PubMed/NCBI

18 

Chen CY, Li ZL, Chung KT, Lu FJ and Chen CH: Liriodenine enhances the apoptosis effect of valproic acid in human colon cancer cells through oxidative stress upregulation and Akt inhibition. Process Biochem. 49:1990–2000. 2014. View Article : Google Scholar

19 

Chen TR, Dorotinsky CS, McGuire LJ, Macy ML and Hay RJ: DLD-1 and HCT-15 cell lines derived separately from colorectal carcinomas have totally different chromosome changes but the same genetic origin. Cancer Genet Cytogenet. 81:103–108. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Gartel AL: Mechanisms of apoptosis induced by anticancer compounds in melanoma cells. Curr Top Med Chem. 12:50–52. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, et al: Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer. 119:2784–2794. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Hirose Y, Berger MS and Pieper RO: Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61:5843–5849. 2001.PubMed/NCBI

23 

Kawabe T: G2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther. 3:513–519. 2004.PubMed/NCBI

24 

Karunagaran D, Rashmi R and Kumar TR: Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets. 5:117–129. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Wang WZ, Cheng J, Luo J and Zhuang SM: Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett. 582:2689–2695. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Sridhar SS, Seymour L and Shepherd FA: Inhibitors of epidermal-growth-factor receptors: A review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4:397–406. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, et al: Contrasting effects of the cytotoxic anticancer drug gemcitabine and the EGFR tyrosine kinase inhibitor gefitinib on NK cell-mediated cytotoxicity via regulation of NKG2D ligand in non-small-cell lung cancer cells. PLoS One. 10:e01398092015. View Article : Google Scholar : PubMed/NCBI

28 

Cui F, Wang W, Wu D, He X, Wu J and Wang M: Overexpression of cathepsin L is associated with gefitinib resistance in non-small cell lung cancer. Clin Transl Oncol. 18:722–727. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Li N, Li H, Su F, Li J, Ma X and Gong P: Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. Int J Clin Exp Pathol. 8:9010–9020. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hsieh C, Lin YW, Chen CH, Ku W, Ma F, Yu H and Chu C: Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncol Lett 15: 5915-5923, 2018.
APA
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., & Chu, C. (2018). Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncology Letters, 15, 5915-5923. https://doi.org/10.3892/ol.2018.8052
MLA
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., Chu, C."Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells". Oncology Letters 15.4 (2018): 5915-5923.
Chicago
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., Chu, C."Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells". Oncology Letters 15, no. 4 (2018): 5915-5923. https://doi.org/10.3892/ol.2018.8052
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh C, Lin YW, Chen CH, Ku W, Ma F, Yu H and Chu C: Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncol Lett 15: 5915-5923, 2018.
APA
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., & Chu, C. (2018). Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncology Letters, 15, 5915-5923. https://doi.org/10.3892/ol.2018.8052
MLA
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., Chu, C."Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells". Oncology Letters 15.4 (2018): 5915-5923.
Chicago
Hsieh, C., Lin, Y., Chen, C., Ku, W., Ma, F., Yu, H., Chu, C."Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells". Oncology Letters 15, no. 4 (2018): 5915-5923. https://doi.org/10.3892/ol.2018.8052
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