Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status

  • Authors:
    • Luigi Cavanna
    • Pietro Seghini
    • Camilla Di Nunzio
    • Elena Orlandi
    • Emanuele Michieletti
    • Elisa Maria Stroppa
    • Patrizia Mordenti
    • Chiara Citterio
    • Stefano Vecchia
    • Adriano Zangrandi
  • View Affiliations

  • Published online on: February 14, 2018     https://doi.org/10.3892/ol.2018.8054
  • Pages: 5787-5791
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Abstract

Central nervous system (CNS) metastases from cancers of the gastrointestinal tract (GIT) are rare, and occur in 0.16‑0.69% of patients with gastric or gastro‑esophageal (GE) junction cancer. Overexpression of the human epidermal growth factor 2 (HER‑2) is associated with poor prognosis in the absence of HER‑2‑targeted therapy, and with an increased incidence of CNS metastases in patients with breast cancer. The role of HER‑2 overexpression in CNS metastases is not well known in gastric adenocarcinoma. The purpose of the present retrospective study was to assess the incidence of CNS metastases and to evaluate the associations between the CNS and HER‑2 status in a series of consecutive patients with gastric or GE junction cancer. Between 2007 and 2013, 300 patients with gastric cancer (GC) or gastroesophageal junction, were admitted to Piacenza General Hospital, Italy. These cases were retrospectively analyzed to evaluate CNS metastases. The metastases were diagnosed with imaging techniques performed on symptomatic patients. Gastric histological samples of patients with CNS metastases were reviewed and tested for HER‑2. A total of 7 of the 300 patients (2.33%) with GC were observed to have CNS metastases and 6 (85.71%) had HER‑2 positive disease. These patients exhibited a poor prognosis with a median overall survival rate of 4.1 months (range, 2.1‑6.6 months). These results suggested there may be CNS recurrence susceptibility in patients with HER‑2 positive GC. To the best of our knowledge, this is the first report that associates CNS metastases and HER‑2 status in gastric or GE junction cancer.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cavanna L, Seghini P, Di Nunzio C, Orlandi E, Michieletti E, Stroppa EM, Mordenti P, Citterio C, Vecchia S, Zangrandi A, Zangrandi A, et al: Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status. Oncol Lett 15: 5787-5791, 2018
APA
Cavanna, L., Seghini, P., Di Nunzio, C., Orlandi, E., Michieletti, E., Stroppa, E.M. ... Zangrandi, A. (2018). Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status. Oncology Letters, 15, 5787-5791. https://doi.org/10.3892/ol.2018.8054
MLA
Cavanna, L., Seghini, P., Di Nunzio, C., Orlandi, E., Michieletti, E., Stroppa, E. M., Mordenti, P., Citterio, C., Vecchia, S., Zangrandi, A."Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status". Oncology Letters 15.4 (2018): 5787-5791.
Chicago
Cavanna, L., Seghini, P., Di Nunzio, C., Orlandi, E., Michieletti, E., Stroppa, E. M., Mordenti, P., Citterio, C., Vecchia, S., Zangrandi, A."Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status". Oncology Letters 15, no. 4 (2018): 5787-5791. https://doi.org/10.3892/ol.2018.8054