|
1
|
Degterev A, Huang Z, Boyce M, Li Y, Jagtap
P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA and Yuan J:
Chemical inhibitor of nonapoptotic cell death with therapeutic
potential for ischemic brain injury. Nat Chem Biol. 1:112–119.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Cao JY and Dixon SJ: Mechanisms of
ferroptosis. Cell Mol Life Sci. 73:2195–2209. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Fuchs Y and Steller H: Programmed cell
death in animal development and disease. Cell. 147:742–758. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Magtanong L, Ko PJ and Dixon SJ: Emerging
roles for lipids in non-apoptotic cell death. Cell Death Differ.
23:1099–1109. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Yang WS and Stockwell BR: Ferroptosis:
Death by lipid peroxidation. Trends Cell Biol. 26:165–176. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Skouta R, Dixon SJ, Wang J, Dunn DE, Orman
M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A and
Stockwell BR: Ferrostatins inhibit oxidative lipid damage and cell
death in diverse disease models. J Am Chem Soc. 136:4551–4556.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Gao M, Monian P, Quadri N, Ramasamy R and
Jiang X: Glutaminolysis and transferrin regulate ferroptosis. Mol
Cell. 59:298–308. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Friedmann Angeli JP, Schneider M, Proneth
B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch
A, Eggenhofer E, et al: Inactivation of the ferroptosis regulator
Gpx4 triggers acute renal failure in mice. Nat Cell Biol.
16:1180–1191. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hayano M, Yang WS, Corn CK, Pagano NC and
Stockwell BR: Loss of cysteinyl-tRNA synthetase (CARS) induces the
transsulfuration pathway and inhibits ferroptosis induced by
cystine deprivation. Cell Death Differ. 23:270–278. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kerr JF, Wyllie AH and Currie AR:
Apoptosis: A basic biological phenomenon with wide-ranging
implications in tissue kinetics. Br J Cancer. 26:239–257. 1972.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Kroemer G, Galluzzi L, Vandenabeele P,
Abrams J, Alnemri ES, Baehrecke EH, Blagosklonny MV, El-Deiry WS,
Golstein P, Green DR, et al Nomenclature Committee on Cell Death
2009, : Classification of cell death: Recommendations of the
nomenclature committee on cell death 2009. Cell Death Differ.
16:3–31. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Galluzzi L, Vitale I, Abrams JM, Alnemri
ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry
WS, Fulda S, et al: Molecular definitions of cell death
subroutines: Recommendations of the nomenclature committee on cell
death 2012. Cell Death Differ. 19:107–120. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Conrad M and Friedmann Angeli JP:
Glutathione peroxidase 4 (Gpx4) and ferroptosis: What's so special
about it? Mol Cell Oncol. 30:e9950472015. View Article : Google Scholar
|
|
15
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Dixon SJ: Ferroptosis: Bug or feature?
Immunol Rev. 277:150–157. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Muller T, Dewitz C, Schmitz J, Schröder
AS, Bräsen JH, Stockwell BR, Murphy JM, Kunzendorf U and Krautwald
S: Necroptosis and ferroptosis are alternative cell death pathways
that operate in acute kidney failure. Cell Mol Life Sci.
27:2017.(Epub ahead of print).
|
|
18
|
Yang WS and Stockwell BR: Synthetic lethal
screening identifies compounds activating iron-dependent,
nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Chem. Biol. 15:234–245. 2008.
|
|
19
|
Louandre C, Ezzoukhry Z, Godin C, Barbare
JC, Mazière JC, Chauffert B and Galmiche A: Iron-dependent cell
death of hepatocellular carcinoma cells exposed to sorafenib. Int J
Cancer. 133:1732–1742. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Dixon SJ, Patel DN, Welsch M, Skouta R,
Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS
and Stockwell BR: Pharmacological inhibition of cystine-glutamate
exchange induces endoplasmic reticulum stress and ferroptosis.
Elife. 3:e025232014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun
X, Kang R and Tang D: Ferroptosis: Process and function. Cell Death
Differ. 23:369–379. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kurz T, Gustafsson B and Brunk UT:
Intralysosomal iron chelation protects against oxidative
stress-induced cellular damage. FEBS J. 273:3106–3117. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Barradas MA, Jeremy JY, Kontoghiorghes GJ,
Mikhailidis DP, Hoffbrand AV and Dandona P: Iron chelators inhibit
human platelet aggregation, thromboxane A2 synthesis and
lipoxygenase activity. FEBS Lett. 245:105–109. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Soupene E and Kuypers FA: Mammalian
long-chain acyl-CoA synthetases. Exp Biol Med (Maywood).
233:507–521. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Eling N, Reuter L, Hazin J, Hamacher-Brady
A and Brady NR: Identification of artesunate as a specific
activator of ferroptosis in pancreatic cancer cells. Oncoscience.
2:517–532. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Louandre C, Marcq I, Bouhlal H, Lachaier
E, Godin C, Saidak Z, François C, Chatelain D, Debuysscher V,
Barbare JC, et al: The retinoblastoma (Rb) protein regulates
ferroptosis induced by sorafenib in human hepatocellular carcinoma
cells. Cancer Lett. 356:971–977. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
McBean GJ: Cerebral cystine uptake: A tale
of two transporters. Trends Pharmacol Sci. 23:299–302. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Shimada K and Stockwell BR: tRNA synthase
suppression activates de novo cysteine synthesis to compensate for
cystine and glutathione deprivation during ferroptosis. Mol Cell
Oncol. 3:e10910592015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Stipanuk MH, Dominy JE Jr, Lee JI and
Coloso RM: Mammalian cysteine metabolism: New insights into
regulation of cysteine metabolism. J Nutr. 136:1652S–1659S. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
McBean GJ: The transsulfuration pathway: A
source of cysteine for glutathione in astrocytes. Amino Acids.
42:199–205. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kabil O, Vitvitsky V, Xie P and Banerjee
R: The quantitative significance of the transsulfuration enzymes
for H2S production in murine tissues. Antioxid Redox Signal.
15:363–372. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Stipanuk MH and Ueki I: Dealing with
methionine/homocysteine sulfur: cysteine metabolism to taurine and
inorganic sulfur. J Inherit Metab Dis. 34:17–32. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Bannai S, Tsukeda H and Okumura H: Effect
of antioxidants on cultured human diploid fibroblasts exposed to
cystine-free medium. Biochem Biophys Res Commun. 74:1582–1588.
1977. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kryukov GV, Castellano S, Novoselov SV,
Lobanov AV, Zehtab O, Guigó R and Gladyshev VN: Characterization of
mammalian selenoproteomes. Science. 300:1439–1443. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Warner GJ, Berry MJ, Moustafa ME, Carlson
BA, Hatfield DL and Faust JR: Inhibition of selenoprotein synthesis
by selenocysteine tRNA [Ser]Sec lacking isopentenyladenosine. J
Biol Chem. 275:28110–28119. 2000.PubMed/NCBI
|
|
36
|
do Nascimento NC, Menguer PK, Henriques AT
and Fett-Neto AG: Accumulation of brachycerine, an antioxidant
glucosidic indole alkaloid, is induced by abscisic acid, heavy
metal and osmotic stress in leaves of Psychotria brachyceras. Plant
Physiol Biochem. 73:33–40. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Shimada K, Skouta R, Kaplan A, Yang WS,
Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ and
Stockwell BR: Global survey of cell death mechanisms reveals
metabolic regulation of ferroptosis. 12:1–503. 2016.
|
|
38
|
Taylor J: Joint societies CVD prevention
guidelines launched in, May 2012. Eur Heart J.
33:15392012.PubMed/NCBI
|
|
39
|
Gazzerro P, Proto MC, Gangemi G, Malfitano
AM, Ciaglia E, Pisanti S, Santoro A, Laezza C and Bifulco M:
Pharmacological actions of statins: A critical appraisal in the
management of cancer. Pharmacol Rev. 64:102–146. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Ciofu C: The statins as anticancer agents.
Maedica (Buchar). 7:3772012.PubMed/NCBI
|
|
41
|
Altwairgi AK: Statins are potential
anticancerous agents (review). Oncol Rep. 33:1019–1039. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kromer A and Moosmann B: Statin-induced
liver injury involves cross-talk between cholesterol and
selenoprotein biosynthetic pathways. Mol Pharmacol. 75:1421–1429.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhao Y, Hu X, Liu Y, Dong S, Wen Z, He W,
Zhang S, Huang Q and Shi M: ROS signaling under metabolic stress:
Cross-talk between AMPK and AKT pathway. Mol Cancer. 16:792017.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Reisman SA, Yeager RL, Yamamoto M and
Klaassen CD: Increased Nrf2 activation in livers from
keap1-knockdown mice increases expression of cytoprotective genes
that detoxify electrophiles more than those that detoxify reactive
oxygen species. Toxicol Sci. 108:35–47. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Goven D, Boutten A, Lecon-Malas V,
Marchal-Sommé J, Soler P, Boczkowski J and Bonay M: Induction of
heme oxygenase-1, biliverdin reductase and H-ferritin in lung
macrophage in smokers with primary spontaneous pneumothorax: Role
of HIF-1alpha. PLoS One. 5:e108862010. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Kirby J, Halligan E, Baptista MJ, Allen S,
Heath PR, Holden H, Barber SC, Loynes CA, Wood-Allum CA, Lunec J
and Shaw PJ: Mutant SOD1 alters the motor neuronal transcriptome:
Implications for familial ALS. Brain. 128:1686–1706. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R
and Tang D: Activation of the p62-Keap1-NRF2 pathway protects
against ferroptosis in hepatocellular carcinoma cells. Hepatology.
63:173–184. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Shimada K, Hayano M, Pagano NC and
Stockwell BR: Cell-Line selectivity improves the predictive power
of pharmacogenomic analyses and helps identify NADPH as biomarker
for ferroptosis sensitivity. Cell Chem Biol. 23:225–235. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Bedard K and Krause KH: The NOX family of
ROS-generating NADPH oxidases: Physiology and pathophysiology.
Physiol Rev. 87:245–313. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Shindou H and Shimizu T: Acyl-CoA:
Lysophospholipid acyltransferases. J Biol Chem. 284:1–5. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Dixon SJ, Winter GE, Musavi LS, Lee ED,
Snijder B, Rebsamen M, Superti-Furga G and Stockwell BR: Human
haploid cell genetics reveals roles for lipid metabolism genes in
nonapoptotic cell death. ACS Chem Biol. 10:1604–1609. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Cheng Z and Li Y: What is responsible for
the initiating chemistry of iron-mediated lipid peroxidation: An
update. Chem Rev. 107:748–766. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Bogdan AR, Miyazawa M, Hashimoto K and
Tsuji Y: Regulators of iron homeostasis: New players in metabolism,
cell death and disease. Trends Biochem Sci. 41:274–286. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Dixon SJ and Stockwell BR: The role of
iron and reactive oxygen species in cell death. Nat Chem Biol.
10:9–17. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Zhao G, Arosio P and Chasteen ND: Iron
(II) and hydrogen peroxide detoxification by human H-chain
ferritin. An EPR spin-trapping study. Biochemistry. 45:3429–3436.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh
HJ III, Kang R and Tang D: Autophagy promotes ferroptosis by
degradation of ferritin. Autophagy. 12:1425–1428. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Gao M, Monian P, Pan Q, Zhang W, Xiang J
and Jiang X: Ferroptosis is an autophagic cell death process. Cell
Res. 26:1021–1032. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Martin-Sanchez D, Ruiz-Andres O, Poveda J,
Carrasco S, Cannata-Ortiz P, Sanchez-Niño MD, Ruiz Ortega M, Egido
J, Linkermann A, Ortiz A and Sanz AB: Ferroptosis, but not
necroptosis, is important in nephrotoxic folic acid-induced AKI. J
Am Soc Nephrol. 28:218–229. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Zille M, Karuppagounder SS, Chen Y, Gough
PJ, Bertin J, Finger J, Milner TA, Jonas EA and Ratan RR: Neuronal
death after hemorrhagic stroke in vitro and in vivo shares features
of ferroptosis and necroptosis. Stroke. 48:1033–1043. 2017.
View Article : Google Scholar : PubMed/NCBI
|
