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Article

Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma

  • Authors:
    • Peijie Chen
    • Liwen Zhao
    • Xiang Pan
    • Lu Jin
    • Canbin Lin
    • Weijie Xu
    • Jinling Xu
    • Xin Guan
    • Xueling Wu
    • Yong Wang
    • Shangqi Yang
    • Tao Wang
    • Yongqing Lai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Urology, Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, P.R. China, Department of Reproduction, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 5995-6002
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ol.2018.8081
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Abstract

MicroRNAs (miRs) are involved in diverse physiological and developmental processes at the post-transcriptional level in cells. Previous studies have demonstrated that miR‑136‑5p is involved in certain types of cancer. However, the function of miR‑136‑5p in renal cell carcinoma (RCC) remains to be fully elucidated. In present study, miR‑136‑5p expression levels were determined by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), and MTT assays, CCK‑8 assays, Transwell assays, wound healing assays and flow cytometry were performed to investigate the function of miR‑136‑5p in RCC. RT‑qPCR revealed that the expression of miR‑136 was significantly lower in RCC tissues and cells compared with adjacent non‑tumor tissues and cells in vitro. miR‑136‑5pwas also demonstrated to be associated with RCC cell proliferation, viability, migration, invasion and apoptosis. miR‑136‑5p may therefore function as a tumor suppressor in RCC. Further studies are required to elucidate the molecular mechanisms and signaling pathways underlying these functions of miR‑136‑5p, to investigate the potential function of miR‑136‑5p as a biomarker for the early detection and prognosis of RCC, and its potential as a therapeutic target for the treatment of RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen P, Zhao L, Pan X, Jin L, Lin C, Xu W, Xu J, Guan X, Wu X, Wang Y, Wang Y, et al: Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma. Oncol Lett 15: 5995-6002, 2018.
APA
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W. ... Lai, Y. (2018). Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma. Oncology Letters, 15, 5995-6002. https://doi.org/10.3892/ol.2018.8081
MLA
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Wu, X., Wang, Y., Yang, S., Wang, T., Lai, Y."Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma". Oncology Letters 15.4 (2018): 5995-6002.
Chicago
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Wu, X., Wang, Y., Yang, S., Wang, T., Lai, Y."Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma". Oncology Letters 15, no. 4 (2018): 5995-6002. https://doi.org/10.3892/ol.2018.8081
Copy and paste a formatted citation
x
Spandidos Publications style
Chen P, Zhao L, Pan X, Jin L, Lin C, Xu W, Xu J, Guan X, Wu X, Wang Y, Wang Y, et al: Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma. Oncol Lett 15: 5995-6002, 2018.
APA
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W. ... Lai, Y. (2018). Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma. Oncology Letters, 15, 5995-6002. https://doi.org/10.3892/ol.2018.8081
MLA
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Wu, X., Wang, Y., Yang, S., Wang, T., Lai, Y."Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma". Oncology Letters 15.4 (2018): 5995-6002.
Chicago
Chen, P., Zhao, L., Pan, X., Jin, L., Lin, C., Xu, W., Xu, J., Guan, X., Wu, X., Wang, Y., Yang, S., Wang, T., Lai, Y."Tumor suppressor microRNA‑136‑5p regulates the cellular function of renal cell carcinoma". Oncology Letters 15, no. 4 (2018): 5995-6002. https://doi.org/10.3892/ol.2018.8081
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