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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2018 Volume 15 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance

  • Authors:
    • Ales Hlavka
    • Jaroslav Vanasek
    • Karel Odrazka
    • Jan Stuk
    • Martin Dolezel
    • Vit Ulrych
    • Martina Vitkova
    • Jiri Mynarik
    • Iveta Kolarova
    • Zdenka Vilasova
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Radiation Oncology, Oncology Centre, Multiscan and Pardubice Hospital, 53002 Pardubice, Czech Republic
  • Pages: 6009-6014
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ol.2018.8083
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Abstract

Image guided radiation therapy (IGRT) enables the achievement of higher precision in radiation delivery, a reduction in safety margins and a reduced risk of toxicity in healthy tissues. The present study investigated the magnitude of safety margins for the radiation boost setup on skin marks or metal clips implanted into the tumor bed during breast cancer surgery. One hundred eighty‑four patients after breast conserving surgery with implanted metal clips into tumor bed were analyzed. The present study investigated the difference in safety margin required for the treatment setup on skin marks and metal clips. The skin marks were created using a positioning laser system in the treatment room. Metal clips implanted in the tumor bed were registered using IGRT with kilovoltage X‑rays in orthogonal projection. Treatment setup was performed during free breathing. The safety margin corresponding to the planning target volume (PTV) was calculated from the recorded data. Calculated safety margins for the treatment setup on skin marks were 9.4, 11.1 and 11.1 mm in the anteroposterior, craniocaudal, and laterolateral directions, respectively. Corresponding safety margins with the use of IGRT and metal clips registration were 4.7, 5.1 and 5.9 mm, respectively. The safe PTV margin was 12 mm using setup on skin marks without IGRT, whereas a 6‑mm margin was sufficient with the use of metal clip‑based IGRT with daily online correction. IGRT has been adopted as the standard treatment method within the Oncology Centre of Multiscan and Pardubice Hospital (Pardubice, Czech Republic).
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Copy and paste a formatted citation
Spandidos Publications style
Hlavka A, Vanasek J, Odrazka K, Stuk J, Dolezel M, Ulrych V, Vitkova M, Mynarik J, Kolarova I, Vilasova Z, Vilasova Z, et al: Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance. Oncol Lett 15: 6009-6014, 2018.
APA
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V. ... Vilasova, Z. (2018). Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance. Oncology Letters, 15, 6009-6014. https://doi.org/10.3892/ol.2018.8083
MLA
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V., Vitkova, M., Mynarik, J., Kolarova, I., Vilasova, Z."Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance". Oncology Letters 15.4 (2018): 6009-6014.
Chicago
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V., Vitkova, M., Mynarik, J., Kolarova, I., Vilasova, Z."Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance". Oncology Letters 15, no. 4 (2018): 6009-6014. https://doi.org/10.3892/ol.2018.8083
Copy and paste a formatted citation
x
Spandidos Publications style
Hlavka A, Vanasek J, Odrazka K, Stuk J, Dolezel M, Ulrych V, Vitkova M, Mynarik J, Kolarova I, Vilasova Z, Vilasova Z, et al: Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance. Oncol Lett 15: 6009-6014, 2018.
APA
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V. ... Vilasova, Z. (2018). Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance. Oncology Letters, 15, 6009-6014. https://doi.org/10.3892/ol.2018.8083
MLA
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V., Vitkova, M., Mynarik, J., Kolarova, I., Vilasova, Z."Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance". Oncology Letters 15.4 (2018): 6009-6014.
Chicago
Hlavka, A., Vanasek, J., Odrazka, K., Stuk, J., Dolezel, M., Ulrych, V., Vitkova, M., Mynarik, J., Kolarova, I., Vilasova, Z."Tumor bed radiotherapy in women following breast conserving surgery for breast cancer-safety margin with/without image guidance". Oncology Letters 15, no. 4 (2018): 6009-6014. https://doi.org/10.3892/ol.2018.8083
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