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Article Open Access

Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma

  • Authors:
    • Changjiang Feng
    • Jiaqi Wu
    • Fan Yang
    • Mangtang Qiu
    • Shuofeng Hu
    • Saisai Guo
    • Jin Wu
    • Xiaomin Ying
    • Jun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, P.R. China, Computational Omics Laboratory, Beijing Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing 100850, P.R. China, State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing 100850, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6925-6930
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ol.2018.8198
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Abstract

Lung squamous cell carcinoma (LUSC) is the second major type of lung cancer globally. The majority of patients with LUSC are clinically diagnosed at the advanced stages, thus it is urgent to identify suitable prognostic markers for LUSC. B‑cell lymphoma 2 (Bcl‑2) has been widely studied in non‑small cell lung cancer (NSCLC). However, the prognostic role of Bcl‑2 in NSCLC remains conflicting and controversial, particularly for LUSC. Although certain studies have been performed to identify the prognostic value of Bcl‑2, to the best of our knowledge, no study has investigated the prognostic role of Bcl‑2 in LUSC specifically. The present study aimed to comprehensively evaluate the prognostic value of Bcl‑2 in LUSC. Microarray data for LUSC were downloaded from public databases, including the Gene Expression Omnibus and The Cancer Genome Atlas. Microarray data of 901 patients with LUSC from 16 data sets were retrieved. The meta‑z algorithm was applied and the combined z score was identified as ‑2.43, suggesting Bcl‑2 is a favorable prognostic biomarker. Furthermore, immunohistochemical staining of Bcl‑2 expression was performed in a tissue microarray of 72 patients with LUSC and survival analysis demonstrated that patients with high expression Bcl‑2 exhibited significantly more improved overall survival rates compared with those with low Bcl‑2 expression. Multivariate Cox regression revealed that high expression of Bcl‑2 is an independent favorable prognostic factor (hazard ratio, 0.295; confidence interval, 0.097‑0.904; P<0.05). Therefore, the results of the present study demonstrated that Bcl‑2 is a favorable prognostic biomarker in LUSC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Lewis DR, Check DP, Caporaso NE, Travis WD and Devesa SS: US lung cancer trends by histologic type. Cancer. 120:2883–2892. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, et al: Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 439:353–357. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Huang P, Cheng CL, Chang YH, Liu CH, Hsu YC, Chen JS, Chang GC, Ho BC, Su KY, Chen HY and Yu SL: Molecular gene signature and prognosis of non-small cell lung cancer. Oncotarget. 7:51898–51907. 2016.PubMed/NCBI

6 

Tan Q, Wang G, Huang J, Ding Z, Luo Q, Mok T, Tao Q and Lu S: Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking. Onco Targets Ther. 6:1471–1479. 2013.PubMed/NCBI

7 

Botling J, Edlund K, Lohr M, Hellwig B, Holmberg L, Lambe M, Berglund A, Ekman S, Bergqvist M, Pontén F, et al: Biomarker discovery in non-small cell lung cancer: Integrating gene expression profiling, meta-analysis, and tissue microarray validation. Clin Cancer Res. 19:194–204. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, Cabanski CR, Muldrew K, Miller CR, Randell SH, Socinski MA, et al: Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clin Cancer Res. 16:4864–4875. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Raponi M, Zhang Y, Yu J, Chen G, Lee G, Taylor JM, Macdonald J, Thomas D, Moskaluk C, Wang Y and Beer DG: Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res. 66:7466–7472. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lawson MH, Cummings NM, Rassl DM, Vowler SL, Wickens M, Howat WJ, Brenton JD, Murphy G and Rintoul RC: Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer. Br J Cancer. 103:1710–1715. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Dutta C, Day T, Kopp N, van Bodegom D, Davids MS, Ryan J, Bird L, Kommajosyula N, Weigert O, Yoda A, et al: BCL-2 suppresses PARP1 function and nonapoptotic cell death. Cancer Res. 72:4193–4203. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Janumyan Y, Cui Q, Yan L, Sansam CG, Valentin M and Yang E: G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. J Biol Chem. 283:34108–34120. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Daniel JC and Smythe WR: The role of Bcl-2 family members in non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 16:19–27. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Bouchalova K, Kharaishvili G, Bouchal J, Vrbkova J, Megova M and Hlobilkova A: Triple negative breast cancer-BCL2 in prognosis and prediction. Review. Curr Drug Targets. 15:1166–1175. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Renouf DJ, Wood-Baker R, Ionescu DN, Leung S, Masoudi H, Gilks CB and Laskin J: BCL-2 expression is prognostic for improved survival in non-small cell lung cancer. J Thorac Oncol. 4:486–491. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Martinez-Arribas F, Alvarez T, Del Val G, Martín-Garabato E, Núñez-Villar MJ, Lucas R, Sánchez J, Tejerina A and Schneider J: Bcl-2 expression in breast cancer: A comparative study at the mRNA and protein level. Anticancer Res. 27:219–222. 2007.PubMed/NCBI

17 

Martin B, Paesmans M, Berghmans T, Branle F, Ghisdal L, Mascaux C, Meert AP, Steels E, Vallot F, Verdebout JM, et al: Role of Bcl-2 as a prognostic factor for survival in lung cancer: A systematic review of the literature with meta-analysis. Br J Cancer. 89:55–64. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Shibata Y, Hidaka S, Tagawa Y and Nagayasu T: Bcl-2 protein expression correlates with better prognosis in patients with advanced non-small cell lung cancer. Anticancer Res. 24:1925–1928. 2004.PubMed/NCBI

19 

Porebska I, Kosacka M, Wyrodek E and Jankowska R: Expression of p53, bcl-2 and nm23 proteins in squamous cell lung cancer. Pneumonol Alergol Pol. 77:131–137. 2009.(In Polish). PubMed/NCBI

20 

Kim YC, Park KO, Kern JA, Park CS, Lim SC, Jang AS and Yang JB: The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients. Lung Cancer. 22:181–190. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Zhang J, Wang S, Wang L, Wang R, Chen S, Pan B, Sun Y and Chen H: Prognostic value of Bcl-2 expression in patients with non-small-cell lung cancer: A meta-analysis and systemic review. Onco Targets Ther. 8:3361–3369. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Cancer Genome Atlas Research Network: Comprehensive genomic characterization of squamous cell lung cancers. Nature. 489:519–525. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Cancer Genome Atlas Research Network: Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Baty F, Facompré M, Kaiser S, Schumacher M, Pless M, Bubendorf L, Savic S, Marrer E, Budach W, Buess M, et al: Gene profiling of clinical routine biopsies and prediction of survival in non-small cell lung cancer. Am J Respir Crit Care Med. 181:181–188. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Wang Y, Zhao W and Zhou X: Integration of genomic data analysis for demonstrating potential targets in the subgroup populations of squamous cell lung cancer patients. Oncotarget. Jun 15–2016.DOI: 10.18632/oncotarget.10072.

26 

Gentles AJ, Newman AM, Liu CL, Bratman SV, Feng W, Kim D, Nair VS, Xu Y, Khuong A, Hoang CD, et al: The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 21:938–945. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Pøhl M, Olsen KE, Holst R, Ditzel HJ and Hansen O: Tissue microarrays in non-small-cell lung cancer: Reliability of immunohistochemically-determined biomarkers. Clin Lung Cancer. 15:222–230.e3. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Micke P, Mattsson JS, Djureinovic D, Nodin B, Jirström K, Tran L, Jönsson P, Planck M, Botling J and Brunnström H: The impact of the 4th edition of the WHO classification of lung tumours on histological classification of resected pulmonary NSCCs. J Thorac Oncol. 11:862–872. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Li Q, Hou J, Hu Z, Gu B and Shi Y: Multiple mutations of lung squamous cell carcinoma shared common mechanisms. Oncotarget. 7:79629–79636. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Der SD, Sykes J, Pintilie M, Zhu CQ, Strumpf D, Liu N, Jurisica I, Shepherd FA and Tsao MS: Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage IA patients. J Thorac Oncol. 9:59–64. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Hwang KT, Woo JW, Shin HC, Kim HS, Ahn SK, Moon HG, Han W, Park IA and Noh DY: Prognostic influence of BCL-2 expression in breast cancer. Int J Cancer. 131:E1109–E1119. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Peng Y, Wang L, Qing Y, Li C, Ren T, Li Q, Li M, Zhang S, Shan J, Wang G, et al: Polymorphisms of BCL2 and BAX genes associate with outcomes in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Sci Rep. 5:177662015. View Article : Google Scholar : PubMed/NCBI

34 

Singh K and Briggs JM: Functional implications of the spectrum of BCL2 mutations in lymphoma. Mutat Res Rev Mutat Res. 769:1–18. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Feng C, Wu J, Yang F, Qiu M, Hu S, Guo S, Wu J, Ying X and Wang J: Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncol Lett 15: 6925-6930, 2018.
APA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S. ... Wang, J. (2018). Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncology Letters, 15, 6925-6930. https://doi.org/10.3892/ol.2018.8198
MLA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15.5 (2018): 6925-6930.
Chicago
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15, no. 5 (2018): 6925-6930. https://doi.org/10.3892/ol.2018.8198
Copy and paste a formatted citation
x
Spandidos Publications style
Feng C, Wu J, Yang F, Qiu M, Hu S, Guo S, Wu J, Ying X and Wang J: Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncol Lett 15: 6925-6930, 2018.
APA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S. ... Wang, J. (2018). Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncology Letters, 15, 6925-6930. https://doi.org/10.3892/ol.2018.8198
MLA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15.5 (2018): 6925-6930.
Chicago
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15, no. 5 (2018): 6925-6930. https://doi.org/10.3892/ol.2018.8198
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