Open Access

Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma

  • Authors:
    • Changjiang Feng
    • Jiaqi Wu
    • Fan Yang
    • Mangtang Qiu
    • Shuofeng Hu
    • Saisai Guo
    • Jin Wu
    • Xiaomin Ying
    • Jun Wang
  • View Affiliations

  • Published online on: March 7, 2018     https://doi.org/10.3892/ol.2018.8198
  • Pages: 6925-6930
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung squamous cell carcinoma (LUSC) is the second major type of lung cancer globally. The majority of patients with LUSC are clinically diagnosed at the advanced stages, thus it is urgent to identify suitable prognostic markers for LUSC. B‑cell lymphoma 2 (Bcl‑2) has been widely studied in non‑small cell lung cancer (NSCLC). However, the prognostic role of Bcl‑2 in NSCLC remains conflicting and controversial, particularly for LUSC. Although certain studies have been performed to identify the prognostic value of Bcl‑2, to the best of our knowledge, no study has investigated the prognostic role of Bcl‑2 in LUSC specifically. The present study aimed to comprehensively evaluate the prognostic value of Bcl‑2 in LUSC. Microarray data for LUSC were downloaded from public databases, including the Gene Expression Omnibus and The Cancer Genome Atlas. Microarray data of 901 patients with LUSC from 16 data sets were retrieved. The meta‑z algorithm was applied and the combined z score was identified as ‑2.43, suggesting Bcl‑2 is a favorable prognostic biomarker. Furthermore, immunohistochemical staining of Bcl‑2 expression was performed in a tissue microarray of 72 patients with LUSC and survival analysis demonstrated that patients with high expression Bcl‑2 exhibited significantly more improved overall survival rates compared with those with low Bcl‑2 expression. Multivariate Cox regression revealed that high expression of Bcl‑2 is an independent favorable prognostic factor (hazard ratio, 0.295; confidence interval, 0.097‑0.904; P<0.05). Therefore, the results of the present study demonstrated that Bcl‑2 is a favorable prognostic biomarker in LUSC.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Feng C, Wu J, Yang F, Qiu M, Hu S, Guo S, Wu J, Ying X and Wang J: Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncol Lett 15: 6925-6930, 2018
APA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S. ... Wang, J. (2018). Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma. Oncology Letters, 15, 6925-6930. https://doi.org/10.3892/ol.2018.8198
MLA
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15.5 (2018): 6925-6930.
Chicago
Feng, C., Wu, J., Yang, F., Qiu, M., Hu, S., Guo, S., Wu, J., Ying, X., Wang, J."Expression of Bcl-2 is a favorable prognostic biomarker in lung squamous cell carcinoma". Oncology Letters 15, no. 5 (2018): 6925-6930. https://doi.org/10.3892/ol.2018.8198