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Article

Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer

  • Authors:
    • Daisuke Kitajima
    • Atsushi Kasamatsu
    • Dai Nakashima
    • Isao Miyamoto
    • Yasushi Kimura
    • Yosuke Endo‑Sakamoto
    • Masashi Shiiba
    • Hideki Tanzawa
    • Katsuhiro Uzawa
  • View Affiliations / Copyright

    Affiliations: Department of Oral Science, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan, Department of Dentistry and Oral‑Maxillofacial Surgery, Graduate School of Medicine, Chiba University Hospital, Chuo‑ku, Chiba 260‑8670, Japan, Department of Oral and Maxillofacial Surgery, National Defense Medical College Hospital, Tokorozawa, Saitama 359‑8513, Japan, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chuo‑ku, Chiba 260‑8670, Japan
  • Pages: 7237-7242
    |
    Published online on: March 8, 2018
       https://doi.org/10.3892/ol.2018.8212
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Abstract

Angiopoietin-1 (Ang1) is a binding partner of endothelial cell‑specific tyrosine‑protein kinase receptor (Tie2), which serves important roles in vascular development and angiogenesis. Tie2 is closely associated with the metastasis of oral squamous cell carcinomas (OSCCs) however, little is known about the correlation between Tie2 and Ang1. In the present study, the functional mechanisms of the Tie2/Ang1 interaction were investigated using Tie2 overexpressed (oeTie2) OSCC cells and recombinant Ang1 protein. oeTie2 cells had increased cell‑cell and cell‑extracellular matrix adhesions compared with the control cells. Additionally, the adhesive activities increased following treatment with exogenous Ang1, indicating that Ang1 directly enhances Tie2 functions. In the clinical OSCC data from 10 cases positive for regional lymph node metastasis, all cases were negative for Tie2 expression and eight cases (80%) were negative for Ang1 expression. These results suggest that Tie2 and Ang1 serve important roles in cancer metastasis and may be potential biomarkers and therapeutic targets for OSCC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Endo‑Sakamoto Y, Shiiba M, Tanzawa H and Uzawa K: Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncol Lett 15: 7237-7242, 2018.
APA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y. ... Uzawa, K. (2018). Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncology Letters, 15, 7237-7242. https://doi.org/10.3892/ol.2018.8212
MLA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15.5 (2018): 7237-7242.
Chicago
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15, no. 5 (2018): 7237-7242. https://doi.org/10.3892/ol.2018.8212
Copy and paste a formatted citation
x
Spandidos Publications style
Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Endo‑Sakamoto Y, Shiiba M, Tanzawa H and Uzawa K: Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncol Lett 15: 7237-7242, 2018.
APA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y. ... Uzawa, K. (2018). Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer. Oncology Letters, 15, 7237-7242. https://doi.org/10.3892/ol.2018.8212
MLA
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15.5 (2018): 7237-7242.
Chicago
Kitajima, D., Kasamatsu, A., Nakashima, D., Miyamoto, I., Kimura, Y., Endo‑Sakamoto, Y., Shiiba, M., Tanzawa, H., Uzawa, K."Evidence for critical role of Tie2/Ang1 interaction in metastatic oral cancer". Oncology Letters 15, no. 5 (2018): 7237-7242. https://doi.org/10.3892/ol.2018.8212
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