Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells

  • Authors:
    • Jie He
    • Yongyun Li
    • Ying Wang
    • He Zhang
    • Shengfang Ge
    • Xianqun Fan
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7053-7059
    |
    Published online on: March 13, 2018
       https://doi.org/10.3892/ol.2018.8252
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP‑ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified that ART3 is highly expressed in melanoma cells and melanoma tissues compared with the normal RPE cell line, and adjacent normal tissue, respectively. Small interfering RNA and short hairpin RNA were used to silence ART3 gene expression, and the results revealed that the silencing of ART3 inhibits the migratory ability of melanoma cells. The present study indicates that ART3 serves a notable role in the metastasis of melanoma and provides a potential therapeutic target for this disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sato T, Han F and Yamamoto A: The biology and management of uveal melanoma. Curr Oncol Rep. 10:431–438. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Singh AD, Turell ME and Topham AK: Uveal melanoma: Trends in incidence, treatment, and survival. Ophthalmology. 118:1881–1885. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Y, Jia R, Wang J, Xu X, Yao Y, Ge S and Fan X: Targeted silencing of MART-1 gene expression by RNA interference enhances the migration ability of uveal melanoma cells. Int J Mol Sci. 14:15092–15104. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yousef YA and Alkilany M: Characterization, treatment, and outcome of uveal melanoma in the first two years of life. Hematol Oncol Stem Cell Ther. 8:1–5. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Sagoo MS, Harbour JW, Stebbing J and Bowcock AM: Combined PKC and MEK inhibition for treating metastatic uveal melanoma. Oncogene. 33:4722–4723. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Pereira PR, Odashiro AN, Lim LA, Miyamoto C, Blanco PL, Odashiro M, Maloney S, De Souza DF and Burnier MN Jr: Current and emerging treatment options for uveal melanoma. Clin Ophthalmol. 7:1669–1682. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Okazaki IJ and Moss J: Mono-ADP-ribosylation: A reversible posttranslational modification of proteins. Adv Pharmacol. 35:247–280. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Bourne HR: ADP-Ribosylating toxins and G proteins. Insights into signal transduction. Joel Moss and Martha Vaughan, Eds. American society for microbiology, Washington, DC, 1990. xviii, 567 pp., illus. $79; to ASM members, $69. Science. 250:841–842. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Ludden PW: Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes. Mol Cell Biochem. 138:123–129. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Isa M A, Abu-Rafea B, Al-Asiri S, Al-Motawa J, Almady K and Alwaznah R: Ovarian stimulation medications and patients' responses as prognostic factors in IUI-treated infertile Saudi patients. Iran J Reprod Med. 12:493–498. 2014.PubMed/NCBI

11 

Shi W, Gong P, Fan J, Yan YH, Ni L, Wu X, Cui G, Wu X, Gu X and Chen J: The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury. J Mol Histol. 43:37–47. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Rajender S, Avery K and Agarwal A: Epigenetics, spermatogenesis and male infertility. Mutat Res. 727:62–71. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Xiao M, Tang Y, Chen WW, Wang YL, Yang L, Li X, Song GL and Kuang J: Tubb3 regulation by the Erk and Akt signaling pathways: A mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells. Tumour Biol. 37:2353–2363. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Bi J, Li P, Li C, He J, Wang Y, Zhang H, Fan X, Jia R and Ge S: The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration. Tumour Biol. 37:4175–4182. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Method. 25:402–408. 2001. View Article : Google Scholar

16 

Chang W, Dynek JN and Smith S: NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. Biochem J. 391:177–184. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Momii A and Koide SS: Adenosine diphosphate-ribosyltransferase activity in permeabilized mouse testicular cells. Arch Biochem Biophys. 214:628–633. 1982. View Article : Google Scholar : PubMed/NCBI

18 

Okada H, Tajima A, Shichiri K, Tanaka A, Tanaka K and Inoue I: Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. PLoS Genet. 4:e262008. View Article : Google Scholar : PubMed/NCBI

19 

Friedrich M, Grahnert A, Klein C, Tschöp K, Engeland K and Hauschildt S: Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene. Biochim Biophys Acta. 1759:270–280. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Cools-Lartigue JJ, McCauley CS, Marshall JC, Di Cesare S, Gregoire F, Antecka E, Logan P and Burnier MN: Immunomagnetic isolation and in vitro expansion of human uveal melanoma cell lines. Mol Vis. 14:50–55. 2008.PubMed/NCBI

21 

Nareyeck G, Zeschnigk M, Prescher G, Lohmann DR and Anastassiou G: Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3. Exp Eye Res. 83:858–864. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Cheng H, Terai M, Kageyama K, Ozaki S, McCue PA, Sato T and Aplin AE: Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors in metastatic uveal melanoma. Cancer Res. 75:2737–2748. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Carvajal RD, Sosman JA, Quevedo JF, Milhem MM, Joshua AM, Kudchadkar RR, Linette GP, Gajewski TF, Lutzky J, Lawson DH, et al: Effect of selumetinib vs. chemotherapy on progression-free survival in uveal melanoma: A randomized clinical trial. JAMA. 311:2397–2405. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM and Harbour JW: Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin Cancer Res. 18:408–416. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zhang H, Wang H, Zhang J, Qian G, Niu B, Fan X, Lu J, Hoffman AR, Hu JF and Ge S: Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors. Mol Ther. 17:57–64. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Hu S, Luo Q, Cun B, Hu D, Ge S, Fan X and Chen F: The pharmacological NF-κB inhibitor BAY11-7082 induces cell apoptosis and inhibits the migration of human uveal melanoma cells. Int J Mol Sci. 13:15653–15667. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Paraoan L, Gray D, Hiscott P, Garcia-Finana M, Lane B, Damato B and Grierson I: Cathepsin S and its inhibitor cystatin C: Imbalance in uveal melanoma. Front Biosci (Landmark Ed). 14:2504–2513. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Johansson Hertzman C and Brage Egyhazi S: BRAF inhibitors in cancer therapy. Pharmacol Ther. 142:176–182. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He J, Li Y, Wang Y, Zhang H, Ge S and Fan X: Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells. Oncol Lett 15: 7053-7059, 2018.
APA
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., & Fan, X. (2018). Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells. Oncology Letters, 15, 7053-7059. https://doi.org/10.3892/ol.2018.8252
MLA
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., Fan, X."Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells". Oncology Letters 15.5 (2018): 7053-7059.
Chicago
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., Fan, X."Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells". Oncology Letters 15, no. 5 (2018): 7053-7059. https://doi.org/10.3892/ol.2018.8252
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Li Y, Wang Y, Zhang H, Ge S and Fan X: Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells. Oncol Lett 15: 7053-7059, 2018.
APA
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., & Fan, X. (2018). Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells. Oncology Letters, 15, 7053-7059. https://doi.org/10.3892/ol.2018.8252
MLA
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., Fan, X."Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells". Oncology Letters 15.5 (2018): 7053-7059.
Chicago
He, J., Li, Y., Wang, Y., Zhang, H., Ge, S., Fan, X."Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells". Oncology Letters 15, no. 5 (2018): 7053-7059. https://doi.org/10.3892/ol.2018.8252
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team