Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells

He,Jie; Li,Yongyun; Wang,Ying; Zhang,He; Ge,Shengfang; Fan,Xianqun

doi:10.3892/ol.2018.8252

Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells

Authors:
- Jie He
- Yongyun Li
- Ying Wang
- He Zhang
- Shengfang Ge
- Xianqun Fan
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Affiliations: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
Published online on: March 13, 2018 https://doi.org/10.3892/ol.2018.8252
Pages: 7053-7059
Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP‑ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified that ART3 is highly expressed in melanoma cells and melanoma tissues compared with the normal RPE cell line, and adjacent normal tissue, respectively. Small interfering RNA and short hairpin RNA were used to silence ART3 gene expression, and the results revealed that the silencing of ART3 inhibits the migratory ability of melanoma cells. The present study indicates that ART3 serves a notable role in the metastasis of melanoma and provides a potential therapeutic target for this disease.

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