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Article Open Access

Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells

  • Authors:
    • Lei Zhang
    • Hongmei Chen
    • Mingfei Wang
    • Xiaojing Song
    • Fanghui Ding
    • Jun Zhu
    • Xun Li
  • View Affiliations / Copyright

    Affiliations: Fifth General Surgery Department, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Physiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Pathology, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7037-7045
    |
    Published online on: March 14, 2018
       https://doi.org/10.3892/ol.2018.8260
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Abstract

Gastric cancer most commonly occurs in East Asia, and China accounts for more than half the of world's gastric cancer burden. Despite the efficacy of chemotherapy for patients, this treatment leads to significant patient inconvenience, toxicity and cost. The present study aimed to assess a non‑toxic agent, glabridin, as a future chemotherapeutic approach for treating gastric cancer. Using cell proliferation, apoptosis, invasion, and colony formation assays, it was determined that glabridin alone, or in combination with 5‑fluorouracil (5‑FU), inhibited MKN‑45 cell proliferation and invasion, and increased apoptosis. These effects were accompanied by downregulation of p16, E‑cadherin and apoptosis regulator Bcl‑2 protein, and upregulation of N‑cadherin, apoptosis regulator BAX and caspases 3, 8 and 9. The results demonstrated that glabridin may inhibit the malignant proliferation of the human gastric cancer MKN‑45 cell line and enhance the efficiency of 5‑FU. The data indicate that the p16, and potentially the p16/cyclin‑dependent kinase 4/cyclin D1 pathway, may be a novel target for gastric cancer therapy.
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1 

Kásler M, Ottó S and Kenessey I: The current situation of cancer morbidity and mortality in the light of the national cancer registry. Orv Hetil. 158:84–89. 2017.(In Hungarian). View Article : Google Scholar : PubMed/NCBI

2 

Sun X, Liu W, Wu S, Han H, Lin Y and Dai X: The morbidity and mortality trend and prediction of lung cancer in residents of Nangang District of Harbin in China during the past 10 years. Zhongguo Fei Ai Za Zhi. 8:514–517. 2005.(In Chinese). PubMed/NCBI

3 

Fukunaga S, Nagami Y, Shiba M, Ominami M, Tanigawa T, Yamagami H, Tanaka H, Muguruma K, Watanabe T, Tominaga K, et al: Long-term prognosis of expanded-indication differentiated-type early gastric cancer treated with endoscopic submucosal dissection or surgery using propensity score analysis. Gastrointest Endosc. 85:143–152. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Dittmar Y, Schüle S, Koch A, Rauchfuss F, Scheuerlein H and Settmacher U: Predictive factors for survival and recurrence rate in patients with node-negative gastric cancer-a European single-centre experience. Langenbecks Arch Surg. 400:27–35. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Greenhill C: Gastric cancer. Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol. 12:1242015. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Q and Ye M: Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). J Chromatogr A. 1216:1954–1969. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Yang R, Yuan BC, Ma YS, Zhou S and Liu Y: The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 55:5–18. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Chen X, Liu Z, Meng R, Shi C and Guo N: Antioxidative and anticancer properties of Licochalcone A from licorice. J Ethnopharmacol. 198:331–337. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhang LP and Li JG: Glabridin reduces lipopolysaccharide-induced lung injury in rats by inhibiting p38 mitogen activated protein kinase/extracellular regulated protein kinases signaling pathway. Zhonghua Yi Xue Za Zhi. 96:3893–3897. 2016.(In Chinese). PubMed/NCBI

10 

Liu C, Sui H, Zhao Q, Zhang X and Wang W: Enhanced skin permeation of Glabridin using eutectic mixture-based nanoemulsion. Drug Deliv Transl Res. 7:325–332. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ito C, Oi N, Hashimoto T, Nakabayashi H, Aoki F, Tominaga Y, Yokota S, Hosoe K and Kanazawa K: Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. J Nutr Sci Vitaminol (Tokyo). 53:358–365. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Cao J, Chen X, Liang J, Yu XQ, Xu AL, Chan E, Wei D, Huang M, Wen JY, Yu XY, et al: Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra. Drug Metab Dispos. 35:539–553. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Ye X, Jiang F, Li Y, Mu J, Si L, Wang X, Ning S and Li Z: Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. Cancer Sci. 105:875–882. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Tsai YM, Yang CJ, Hsu YL, Wu LY, Tsai YC, Hung JY, Lien CT, Huang MS and Kuo PL: Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. Integr Cancer Ther. 10:341–349. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Tamir S, Eizenberg M, Somjen D, Stern N, Shelach R, Kaye A and Vaya J: Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res. 60:5704–5709. 2000.PubMed/NCBI

16 

Jiang F, Mu J, Wang X, Ye X, Si L, Ning S, Li Z and Li Y: The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells. PLoS One. 9:e966982014. View Article : Google Scholar : PubMed/NCBI

17 

Jiang F, Li Y, Mu J, Hu C, Zhou M, Wang X, Si L, Ning S and Li Z: Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: An epigenetic regulation of miR-148a/SMAd2 signaling. Mol Carcinog. 55:929–940. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Hsieh MJ, Lin CW, Yang SF, Chen MK and Chiou HL: Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 171:3037–3050. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Retraction statement: ‘Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c’. by. Xianqing Ye, Fei Jiang, Yuan Li, Juan Mu, Lu Si, Xingxing Wang, Shilong Ning, Zhong L.. Cancer Sci. 106:1252015. View Article : Google Scholar : PubMed/NCBI

20 

Nabekura T, Yamaki T, Ueno K and Kitagawa S: Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol. 62:867–873. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Khazraei-Moradian S, Ganjalikhani-Hakemi M, Andalib A, Yazdani R, Arasteh J and Kardar GA: The effect of licorice protein fractions on proliferation and apoptosis of gastrointestinal cancer cell lines. Nutr Cancer. 69:330–339. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zhou X, Wang W, Li P, Zheng Z, Tu Y, Zhang Y and You T: Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in inducing gastric cancer cell apoptosis both in vitro and in vivo. Oncol Res. 23:29–34. 2016. View Article : Google Scholar

23 

Alimperti S and Andreadis ST: CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem Cell Res. 14:270–282. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Saika K and Sobue T: Cancer statistics in the world. Gan To Kagaku Ryoho. 40:2475–2480. 2013.(In Japanese). PubMed/NCBI

25 

Zeng H, Zheng R, Zhang S, Zuo T, Xia C, Zou X and Chen W: Esophageal cancer statistics in China, 2011: Estimates based on 177 cancer registries. Thorac Cancer. 7:232–237. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Kinoshita T, Kajiyama K, Hiraga Y, Takahashi K, Tamura Y and Mizutani K: Isoflavan derivatives from Glycyrrhiza glabra (licorice). Heterocycles. 43:581–588. 1996. View Article : Google Scholar

28 

Vaya J, Belinky PA and Aviram M: Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med. 23:302–313. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Fulmer CG, Hoda RS, Pirog EC, Park KJ and Holcomb K: Cytomorphology of gastric-type cervical adenocarcinoma on a ThinPrep Pap test: Report of a p16-positive tumor case. Diagn Cytopathol. 44:710–713. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Kosemehmetoglu K, Ardic F, Karslioglu Y, Kandemir O and Ozcan A: p16 expression predicts neoadjuvant tumor necrosis in osteosarcomas: Reappraisal with a larger series using whole sections. Hum Pathol. 50:170–175. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Benassi MS, Molendini L, Gamberi G, Ragazzini P, Sollazzo MR, Merli M, Asp J, Magagnoli G, Balladelli A, Bertoni F and Picci P: Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. Int J Cancer. 84:489–493. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Dobashi Y, Goto A, Fukayama M, Abe A and Ooi A: Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma. Int J Cancer. 110:532–541. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Maelandsmo GM, Flørenes VA, Hovig E, Oyjord T, Engebraaten O, Holm R, Børresen AL and Fodstad O: Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas. Br J Cancer. 73:909–916. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Rossi KA, Markwalder JA, Seitz SP, Chang CH, Cox S, Boisclair MD, Brizuela L, Brenner SL and Stouten PF: Understanding and modulating cyclin-dependent kinase inhibitor specificity: Molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors. J Comput Aided Mol Des. 19:111–122. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Lee SK, Park KK, Park JH, Lim SS and Chung WY: The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction. Phytother Res. 27:1776–1783. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Jo EH, Hong HD, Ahn NC, Jung JW, Yang SR, Park JS, Kim SH, Lee YS and Kang KS: Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 52:1715–1719. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Jo EH, Kim SH, Ra JC, Kim SR, Cho SD, Jung JW, Yang SR, Park JS, Hwang JW, Aruoma OI, et al: Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: Induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett. 230:239–247. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Brahmbhatt H, Oppermann S, Osterlund EJ, Leber B and Andrews DW: Molecular pathways: Leveraging the BCL-2 interactome to kill cancer cells-mitochondrial outer membrane permeabilization and beyond. Clin Cancer Res. 21:2671–2676. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Chen H, Wang M, Song X, Ding F, Zhu J and Li X: Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells. Oncol Lett 15: 7037-7045, 2018.
APA
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., & Li, X. (2018). Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells. Oncology Letters, 15, 7037-7045. https://doi.org/10.3892/ol.2018.8260
MLA
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., Li, X."Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells". Oncology Letters 15.5 (2018): 7037-7045.
Chicago
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., Li, X."Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells". Oncology Letters 15, no. 5 (2018): 7037-7045. https://doi.org/10.3892/ol.2018.8260
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Chen H, Wang M, Song X, Ding F, Zhu J and Li X: Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells. Oncol Lett 15: 7037-7045, 2018.
APA
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., & Li, X. (2018). Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells. Oncology Letters, 15, 7037-7045. https://doi.org/10.3892/ol.2018.8260
MLA
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., Li, X."Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells". Oncology Letters 15.5 (2018): 7037-7045.
Chicago
Zhang, L., Chen, H., Wang, M., Song, X., Ding, F., Zhu, J., Li, X."Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells". Oncology Letters 15, no. 5 (2018): 7037-7045. https://doi.org/10.3892/ol.2018.8260
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