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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2018 Volume 15 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy

  • Authors:
    • Yong Zhang
    • Ailiang Zeng
    • Shuheng Liu
    • Rui Li
    • Xiefeng Wang
    • Wei Yan
    • Hailin Li
    • Yongping You
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7625-7630
    |
    Published online on: March 15, 2018
       https://doi.org/10.3892/ol.2018.8280
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Abstract

MicroRNAs (miRNA) regulate a number of cellular processes. Recent studies have indicated that these molecules function in the epithelial‑mesenchymal transition (EMT). However, the crucial systematic role of EMT and miRNAs together in glioblastoma (GBM) remains poorly understood. The present study demonstrated that EMT was closely associated with malignant progression and clinical outcome using three independent glioma databases (GSE16011, Rembrandt and The Cancer Genome Atlas). Furthermore, integrated analysis of miRNAs and mRNA profiling in 491 GBM samples revealed an EMT biological process associated with an miRNA profile (19 positively and 18 negatively correlated miRNAs). Among these miRNAs, miR‑95 and miR‑223 indicated a high level of functional validation, reflecting their positive correlation with EMT. Additionally, the upregulation of miR‑95, which was negatively correlated with EMT, inhibited cellular invasion in glioma U251 and LN229 cells and decreased the expression of the mesenchymal marker N‑catenin, whereas an miRNA positively correlated with EMT, miR‑223, exhibited the opposite effect. Therefore, the results of the present study could further enhance the current understanding of the functions of miRNAs in GBM, indicating that the EMT‑specific miRNA signature may represent a novel target for GBM therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zeng A, Liu S, Li R, Wang X, Yan W, Li H and You Y: Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy. Oncol Lett 15: 7625-7630, 2018.
APA
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W. ... You, Y. (2018). Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy. Oncology Letters, 15, 7625-7630. https://doi.org/10.3892/ol.2018.8280
MLA
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W., Li, H., You, Y."Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy". Oncology Letters 15.5 (2018): 7625-7630.
Chicago
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W., Li, H., You, Y."Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy". Oncology Letters 15, no. 5 (2018): 7625-7630. https://doi.org/10.3892/ol.2018.8280
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zeng A, Liu S, Li R, Wang X, Yan W, Li H and You Y: Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy. Oncol Lett 15: 7625-7630, 2018.
APA
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W. ... You, Y. (2018). Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy. Oncology Letters, 15, 7625-7630. https://doi.org/10.3892/ol.2018.8280
MLA
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W., Li, H., You, Y."Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy". Oncology Letters 15.5 (2018): 7625-7630.
Chicago
Zhang, Y., Zeng, A., Liu, S., Li, R., Wang, X., Yan, W., Li, H., You, Y."Genome‑wide identification of epithelial‑mesenchymal transition‑associated microRNAs reveals novel targets for glioblastoma therapy". Oncology Letters 15, no. 5 (2018): 7625-7630. https://doi.org/10.3892/ol.2018.8280
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