Significance of cytodiagnosis in primary carcinoid tumor of the middle ear: A case report

Sato,Kiminobu; Mihashi,Ryota; Kurita,Takashi; Umeno,Hirohito; Yoshida,Tomoko; Kawahara,Akihiko; Akiba,Jun; Yano,Hirohisa

doi:10.3892/ol.2018.8302

May-2018 Volume 15 Issue 5

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May-2018 Volume 15 Issue 5

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Case Report

Significance of cytodiagnosis in primary carcinoid tumor of the middle ear: A case report

Authors:
- Kiminobu Sato
- Ryota Mihashi
- Takashi Kurita
- Hirohito Umeno
- Tomoko Yoshida
- Akihiko Kawahara
- Jun Akiba
- Hirohisa Yano
View Affiliations / Copyright

Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan, Department of Diagnostic Pathology, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan, Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 8300011, Japan
Pages: 8062-8066
|
Published online on: March 20, 2018

https://doi.org/10.3892/ol.2018.8302
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Abstract

Primary carcinoid tumors of the middle ear are uncommon. Cytodiagnosis of the middle ear is not usually performed as a preoperative examination because of the anatomical structure of the middle ear. To the best of our knowledge, the present study reports for the first time a case of a carcinoid tumor of the middle ear, which was preoperatively diagnosed using cytodiagnosis, and also review current literature. A 22‑year‑old woman complained of left‑sided otalgia. A subcutaneous tumor in the left middle ear was observed. Magnetic resonance imaging revealed that the tumor was primarily present in the tympanic cavity of the middle ear and extended to the mastoid antrum and mastoid cells of the middle ear and to the external acoustic meatus. Fine needle aspiration cytology was performed from the tumor protruding into the external acoustic meatus. Cytologically, the tumor was composed of small uniform cells with small round nuclei and granular eosinophilic cytoplasm, arranged in a nested pattern. Tumor cells were immunocytochemically positive for synaptophysin and cytokeratin CAM5.2. These results indicated that this was a neuroendocrine tumor. No other tumor lesions were identified on computed tomography scans, and the tumor was considered to be the primary lesion. Tympanoplasty and mastidectomy were then performed and carcinoid tumor was diagnosed in the postoperative pathological diagnosis. To the best of our knowledge, the present study is the first to report on preoperative cytodiagnosis for carcinoid tumors of the middle ear.

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1	Soga J: Carcinoid and their variant endocrinomas. An analysis of 11842 reported cases. J Exp Clin Cancer Res. 22:517–530. 2003.PubMed/NCBI
2	Godwin JD II: Carcinoid tumors. An analysis of 2,837 cases. Cancer. 36:560–569. 1975. View Article : Google Scholar : PubMed/NCBI
3	Ramsey MJ, Nadol JB Jr, Pilch BZ and Mckenna MJ: Carcinoid tumor of the middle ear: Clinical features, recurrences, and metastases. Laryngoscope. 115:1660–1666. 2005. View Article : Google Scholar : PubMed/NCBI
4	Tamai S, Iri H, Maruyama T, Kasahara M, Akatsuka S, Sakurai S and Murakami Y: Laryngeal carcinoid tumor: Light and electron microscopic studies. Cancer. 48:2256–2259. 1981. View Article : Google Scholar : PubMed/NCBI
5	Kunz PL: Carcinoid and neuroendocrine tumors: Building on success. J Clin Oncol. 33:1855–1863. 2015. View Article : Google Scholar : PubMed/NCBI
6	Krouse JH, Nadol JB Jr and Goodman ML: Carcinoid tumors of the middle ear. Ann Otol Rhinol Laryngol. 99:547–552. 1990. View Article : Google Scholar : PubMed/NCBI
7	Inoue S, Tanaka K and Kannae S: Primary carcinoid tumor of the ear. Virchows Arch A Pathol Anat Histol. 396:357–363. 1982. View Article : Google Scholar : PubMed/NCBI
8	Ohta Y, Morihana T, Hanada Y, Imai T, Iwamoto Y, Uno A, Kawashima T, Hasegawa T, Kitahara T, Morii E and Inohara H: A clinical study of 61 cases of tumorous disease in external ear canal: Diagnosis of tumor. Otol Jpn. 25:771–776. 2015.
9	Mohan H, Handa U, Amanjit, Kotwal SA and Dass A: Adenoid cystic carcinoma of the external auditory canal. A case report with diagnosis by fine needle aspiration. Acta Cytol. 47:792–794. 2003. View Article : Google Scholar : PubMed/NCBI
10	Murphy GF, Pilch BZ, Dickersin GR, Goodman ML and Nadol JB Jr: Carcinoid tumor of the middle ear. Am J Clin Pathol. 73:816–823. 1980. View Article : Google Scholar : PubMed/NCBI
11	Torske KR and Thompson LD: Adenoma versus carcinoid tumor of the middle ear: A Study of 48 cases and review of the literature. Mod Pathol. 15:543–555. 2002. View Article : Google Scholar : PubMed/NCBI
12	Renshaw AA, Haja J, Lozano RL and Wilbur DC: Cytology Committee, College of American Pathologists: Distinguishing carcinoid tumor from small cell carcinoma of the lung: Correlating cytologic features and performance in the College of American Pathologists Non-Gynecologic Cytology Program. Arch Pathol Lab Med. 129:614–618. 2005.PubMed/NCBI
13	Burke AP, Thomas RM, Elsayed AM and Sobin LH: Carcinoids of the jejunum and ileum: An immnohistochemical and climicopathologic study of 167 cases. Cancer. 79:1086–1093. 1997. View Article : Google Scholar : PubMed/NCBI
14	Sato K, Higaki Y, Sakaguchi S, Hirano M, Tanimura A and Sasaguri Y: Carcinoid tumor of the larynx. Auris Nasus Larynx. 18:39–53. 1991. View Article : Google Scholar : PubMed/NCBI
15	Manni JJ, Faverly DR and Van Haelst UJ: Primary carcinoid tumors of the middle ear. Report on four cases and review of the literature. Arch Otolaryngol Head Neck Surg. 118:1341–1347. 1992. View Article : Google Scholar : PubMed/NCBI
16	Knerer B, Matula C, Youssefzadeh S, Ulrich W and Swoboda H: Treatment of a local recurrence of a carcinoid tumor of the middle ear by extended subtotal petrosectomy. Eur Arch Otorhinolaryngol. 255:57–61. 1998. View Article : Google Scholar : PubMed/NCBI
17	Inzani F, Petrone G, Fadda S and Rindi G: Cyto-histology in NET: What is necessary today and what is the future. Rev Endocr Metab Disore. 2017.Doi: 10.1007/s11154-017-9428-x. View Article : Google Scholar
18	Biancosino C, Krüger M, Vollmer E and Welker L: Intraoperative fine needle apirations-dignosis and typing of lung cancer in small biopsies: Challenges and limitations. Diagn Pathol. 11:592016. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significance of cytodiagnosis in primary carcinoid tumor of the middle ear: A case report

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