Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site

  • Authors:
    • Yufeng Li
    • Wenyue Dong
    • Xijin Shan
    • Hui Hong
    • Yan Liu
    • Yankun Liu
    • Xiaohui Liu
    • Xiaojun Zhang
    • Jinghua Zhang
  • View Affiliations / Copyright

    Affiliations: The Cancer Institute, Affiliated Tangshan People's Hospital of North China University of Science and Technology, Tangshan, Hebei 063001, P.R. China, Department of Anesthesiology, Affiliated Tangshan People's Hospital of North China University of Science and Technology, Tangshan, Hebei 063001, P.R. China, Department of Surgery, Rizhao Port Hospital, Rizhao, Shandong 276800, P.R. China, Department of Head, Neck and Breast Surgery, Shangrao People's Hospital, Shangrao, Jiangxi 334000, P.R. China, Department of Bioengineering, College of Life Sciences, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China, Department of Thoracic Surgery, Affiliated Tangshan People's Hospital of North China University of Science and Technology, Tangshan, Hebei 063001, P.R. China, Department of Internal Medicine, Affiliated Zunhua People's Hospital of North China University of Science and Technology, Zunhua, Hebei 064200, P.R. China
  • Pages: 8011-8018
    |
    Published online on: March 21, 2018
       https://doi.org/10.3892/ol.2018.8314
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mitofusin 2 (Mfn2) is expressed in numerous human tissues and serves a pivotal role in cell proliferation. However, Mfn2 is considered as an anti‑tumor gene, and is silenced in human malignant tumors, including those of breast cancer. However, the mechanisms contributing to Mfn2 silencing and the mechanism of its anti‑tumor function in breast cancer remain unclear. In the present study, hypoexpression of Mfn2, and hypermethylation of its promoter, was confirmed in human breast cancer cells and in breast cancer tissues by reverse transcription‑quantitative polymerase chain reaction (PCR) and methylation specific PCR, respectively. Chemical demethylation treatment with 5‑aza‑2'‑deoxycytidine upregulated the mRNA expression level of Mfn2 in MCF‑7 cells in a dose‑dependent manner. In addition, overexpression of Mfn2 repressed the proliferation, migration and invasion of MCF‑7 cells, mediated by inhibition of the Ras‑extracellular signal‑regulated kinase (ERK)1/2 signaling pathway. However, overexpression of Mfn2 with deletion of the p21Ras motif (Mfn2ΔRas) and protein kinase A (PKA) phosphorylation site (Mfn2ΔPKA) partially reduced the anti‑tumor function of Mfn2, and inhibited the Ras‑ERK1/2 signaling pathway. Taken together, the present study confirmed the anti‑tumor effects of Mfn2 in human breast cancer and clarified that the mechanism of its anti‑tumor functions includes promoter DNA methylation, the P21Ras binding site and PKA phosphorylation.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Fojo T: Multiple paths to a drug resistance phenotype: Mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs. Drug Resist Updat. 10:59–67. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao RP and Tang J: Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol. 6:872–883. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Zhang D, Ma C, Li S, Ran Y, Chen J, Lu P, Shi S and Zhu D: Effect of Mitofusin 2 on smooth muscle cells proliferation in hypoxic pulmonary hypertension. Microvasc Res. 84:286–296. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Zhang GE, Jin HL, Lin XK, Chen C, Liu XS, Zhang Q and Yu JR: Anti-tumor effects of Mfn2 in gastric cancer. Int J Mol Sci. 14:13005–13021. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Wang W, Sun Q, Wu Z, Zhou D, Wei J, Xie H, Zhou L and Zheng S: Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Front Biosci (Landmark Ed). 18:1141–1149. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Jin B, Fu G, Pan H, Cheng X, Zhou L, Lv J, Chen G and Zheng S: Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma. Med Oncol. 28 Suppl 1:S373–S380. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ma L, Liu Y, Geng C, Qi X and Jiang J: Estrogen receptor β inhibits estradiol-induced proliferation and migration of MCF-7 cells through regulation of mitofusin 2. Int J Oncol. 42:1993–2000. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Xia Y, Wu YQ, Zhang L, Li XL, Yuan HL, He XJ, Tao DD, Gong JP and Qiu FZ: Effects of mitofusin-2 gene on proliferation and chemosensitivity of human breast carcinoma cell line MCF-7. Ai Zheng. 26:815–819. 2007.(In Chinese). PubMed/NCBI

10 

Jones PA: Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat Rev Genet. 13:484–492. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Chik F and Szyf M: Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis. 32:224–232. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Antequera F and Bird A: Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci USA. 90:11995–11999. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Bergman Y and Cedar H: DNA methylation dynamics in health and disease. Nat Struct Mol Biol. 20:274–281. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Akhavan-Niaki H and Samadani AA: DNA methylation and cancer development: Molecular mechanism. Cell Biochem Biophys. 67:501–513. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kanwal R and Gupta S: Epigenetic modifications in cancer. Clin Genet. 81:303–311. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Zhou W, Cao WJ, Chen LL, Xiaomei G and Guanghui CH: Effect of mitofusin 2 gene with protein kinase A phosphorylation site deletion on the proliferation of vascular smooth muscle cells. J Clin Rehabilitative Tissue Engineering Res. 14:1322–1325. 2010.

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Gnyszka A, Jastrzebski Z and Flis S: DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer. Anticancer Res. 33:2989–2996. 2013.PubMed/NCBI

19 

Yoo CB and Jones PA: Epigenetic therapy of cancer: Past, present and future. Nat Rev Drug Discov. 5:37–50. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Lee S, Kim HS, Roh KH, Lee BC, Shin TH, Yoo JM, Kim YL, Yu KR, Kang KS and Seo KW: DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells. Sci Rep. 5:80202015. View Article : Google Scholar : PubMed/NCBI

21 

Xu J, Huo D, Chen Y, Nwachukwu C, Collins C, Rowell J, Slamon DJ and Olopade OI: CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. Breast Cancer Res Treat. 120:593–601. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Guo Y, Stacey DW and Hitomi M: Post-transcriptional regulation of cyclin D1 expression during G2 phase. Oncogene. 21:7545–7556. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Sorianello E, Soriano FX, Fernandez-Pascual S, Sancho A, Naon D, Vila-Caballer M, Gonzalez-Navarro H, Portugal J, Andres V, Palacin M and Zorzano A: The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells. Cardiovasc Res. 94:38–47. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Vucic EA, Brown CJ and Lam WL: Epigenetics of cancer progression. Pharmacogenomics. 9:215–234. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Tada M, Kanai F, Tanaka Y, Tateishi K, Ohta M, Asaoka Y, Seto M, Muroyama R, Fukai K, Imazeki F, et al: Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma. Clin Cancer Res. 14:3768–3776. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Duffy MJ, Napieralski R, Martens JW, Span PN, Spyratos F, Sweep FC, Brunner N, Foekens JA and Schmitt M: EORTC PathoBiology Group: Methylated genes as new cancer biomarkers. Eur J Cancer. 45:335–346. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Tost J, Hamzaoui H, Busato F, Neyret A, Mourah S, Dupont JM and Bouizar Z: Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. Epigenetics. 6:1035–1046. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Caffarelli E and Filetici P: Epigenetic regulation in cancer development. Front Biosci (Landmark Ed). 16:2682–2694. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Coppedè F: The role of epigenetics in colorectal cancer. Expert Rev Gastroenterol Hepatol. 8:935–948. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Milavetz BI and Balakrishnan L: Viral epigenetics. Methods Mol Biol. 1238:569–596. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Wu Y, Sarkissyan M and Vadgama JV: Epigenetics in breast and prostate cancer. Methods Mol Biol. 1238:425–466. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Zhou X, Zhang L, Zheng B, Yan Y, Zhang Y, Xie H, Zhou L, Zheng S and Wang W: MicroRNA-761 is upregulated in hepatocellular carcinoma and regulates tumorigenesis by targeting Mitofusin-2. Cancer Sci. 107:424–432. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Santel A and Fuller MT: Control of mitochondrial morphology by a human mitofusin. J Cell Sci. 114:867–874. 2001.PubMed/NCBI

34 

Rojo M, Legros F, Chateau D and Lombès A: Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci. 115:1663–1674. 2002.PubMed/NCBI

35 

Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL and Youle RJ: Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol. 159:931–938. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE and Chan DC: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 160:189–200. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Stefansson OA, Jonasson JG, Olafsdottir K, Hilmarsdottir H, Olafsdottir G, Esteller M, Johannsson OT and Eyfjord JE: CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer. Epigenetics. 6:638–649. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Wang W, Zhu F, Wang S, Wei J, Jia C, Zhang Y, Zhou L, Xie H and Zheng S: HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo. Oncol Rep. 24:183–188. 2010.PubMed/NCBI

39 

Xia Y, Wu Y, He X, Gong J and Qiu F: Effects of mitofusin-2 gene on cell proliferation and chemotherapy sensitivity of MCF-7. J Huazhong Univ Sci Technolog Med Sci. 28:185–189. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Wang W, Zhou D, Wei J, Wu Z, Cheng X, Sun Q, Xie H, Zhou L and Zheng S: Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells. Biochem Biophys Res Commun. 421:355–360. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C and Archer SL: Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. FASEB J. 26:2175–2186. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Lou Y, Li R, Liu J, Zhang Y, Zhang X, Jin B, Liu Y, Wang Z, Zhong H, Wen S and Han B: Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma. Med Oncol. 32:1322015. View Article : Google Scholar : PubMed/NCBI

43 

Lou Y, Zhang Y, Li R, Gu P, Xiong L, Zhong H, Zhang W and Han B: Transcriptional profiling revealed the anti-proliferative effect of MFN2 deficiency and identified risk factors in lung adenocarcinoma. Tumour Biol. 37:8643–8655. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Ansurudeen I, Willenberg HS, Kopprasch S, Krug AW, Ehrhart-Bornstein M and Bornstein SR: Endothelial factors mediate aldosterone release via PKA-independent pathways. Mol Cell Endocrinol. 300:66–70. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Martini CN, Plaza MV and Vila Mdel C: PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation. Mol Cell Endocrinol. 298:42–47. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O and Degerman E: Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B protein kinase A, Epac and lipolysis. Cell Signal. 21:760–766. 2009. View Article : Google Scholar : PubMed/NCBI

47 

McConnachie G, Langeberg LK and Scott JD: AKAP signaling complexes: Getting to the heart of the matter. Trends Mol Med. 12:317–323. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Lorenowicz MJ, Fernandez-Borja M, Kooistra MR, Bos JL and Hordijk PL: PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol. 87:779–792. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Kannan A, Wells RB, Sivakumar S, Komatsu S, Singh KP, Samten B, Philley JV, Sauter ER, Ikebe M, Idell S, et al: Mitochondrial reprogramming regulates breast cancer progression. Clin Cancer Res. 22:3348–3360. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Dong W, Shan X, Hong H, Liu Y, Liu Y, Liu X, Zhang X and Zhang J: The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site. Oncol Lett 15: 8011-8018, 2018.
APA
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y. ... Zhang, J. (2018). The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site. Oncology Letters, 15, 8011-8018. https://doi.org/10.3892/ol.2018.8314
MLA
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y., Liu, X., Zhang, X., Zhang, J."The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site". Oncology Letters 15.5 (2018): 8011-8018.
Chicago
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y., Liu, X., Zhang, X., Zhang, J."The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site". Oncology Letters 15, no. 5 (2018): 8011-8018. https://doi.org/10.3892/ol.2018.8314
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Dong W, Shan X, Hong H, Liu Y, Liu Y, Liu X, Zhang X and Zhang J: The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site. Oncol Lett 15: 8011-8018, 2018.
APA
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y. ... Zhang, J. (2018). The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site. Oncology Letters, 15, 8011-8018. https://doi.org/10.3892/ol.2018.8314
MLA
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y., Liu, X., Zhang, X., Zhang, J."The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site". Oncology Letters 15.5 (2018): 8011-8018.
Chicago
Li, Y., Dong, W., Shan, X., Hong, H., Liu, Y., Liu, Y., Liu, X., Zhang, X., Zhang, J."The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site". Oncology Letters 15, no. 5 (2018): 8011-8018. https://doi.org/10.3892/ol.2018.8314
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team