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Review

Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)

  • Authors:
    • Xiaolei Ren
    • Chao Tu
    • Zhenchu Tang
    • Ruofei Ma
    • Zhihong Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Orthopaedics, Beijing Jishuitan Hospital, Beijing 100035, P.R. China
  • Pages: 7489-7496
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    Published online on: March 22, 2018
       https://doi.org/10.3892/ol.2018.8318
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Abstract

Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α‑thalassemia/mental retardation syndrome X‑linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently associated with α‑thalassemia syndrome. Cancer cells depend on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative programmed mortality. Loss of ATRX is associated with ALT in sarcoma. In the present review, recent whole genome and/or whole exome genomic studies are summarized. In addition ATRX immunohistochemistry and ALT fluorescence in situ hybridization in sarcomas of various subtypes and at diverse sites, including osteosarcoma, leiomyosarcoma, liposarcoma, angiosarcoma and chondrosarcoma are evaluated. The present review involves certain studies associated with the molecular mechanisms underlying the loss of ATRX controlling the activation of ALT in sarcomas. Identification of the loss of ATRX and ALT in sarcomas may provide novel methods for the treatment of aggressive sarcomas.
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View References

1 

Gibbons RJ, Picketts DJ, Villard L and Higgs DR: Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome). Cell. 80:837–845. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Villard L and Fontes M: Alpha-thalassemia/mental retardation syndrome, X-Linked (ATR-X, MIM #301040, ATR-X/XNP/XH2 gene MIM #300032). Eur J Hum Genet. 10:223–225. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Qadeer ZA, Harcharik S, Valle-Garcia D, Chen C, Birge MB, Vardabasso C, Duarte LF and Bernstein E: Decreased expression of the chromatin remodeler ATRX associates with melanoma progression. J Invest Dermatol. 134:1768–1772. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Cai J, Chen J, Zhang W, Yang P, Zhang C, Li M, Yao K, Wang H, Li Q, Jiang C and Jiang T: Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors. Oncotarget. 6:18105–18115. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Gibbons RJ and Higgs DR: Molecular-clinical spectrum of the ATR-X syndrome. Am J Med Genet. 97:204–212. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontès M and Colleaux L: Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet. 7:679–684. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, et al: Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci USA. 111:E5564–E5573. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Reimann E, Kõks S, Ho XD, Maasalu K and Märtson A: Whole exome sequencing of a single osteosarcoma case-integrative analysis with whole transcriptome RNA-seq data. Hum Genomics. 8:202014. View Article : Google Scholar : PubMed/NCBI

9 

Bousquet M, Noirot C, Accadbled F, de Gauzy Sales J, Castex MP, Brousset P and Gomez-Brouchet A: Whole-exome sequencing in osteosarcoma reveals important heterogeneity of genetic alterations. Ann Oncol. 27:738–744. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Joseph CG, Hwang H, Jiao Y, Wood LD, Kinde I, Wu J, Mandahl N, Luo J, Hruban RH, Diaz LA Jr, et al: Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas. Genes Chromosomes Cancer. 53:15–24. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Li D, Yuan Q and Wang W: The role of telomeres in musculoskeletal diseases. J Int Med Res. 40:1242–1250. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Ozturk MB, Li Y and Tergaonkar V: Current insights to regulation and role of telomerase in human diseases. Antioxidants (Basel). 6:pii: E17. 2017.PubMed/NCBI

13 

Henderson ER and Blackburn EH: An overhanging 3′ terminus is a conserved feature of telomeres. Mol Cell Biol. 9:345–348. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Hayflick L and Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res. 25:585–621. 1961. View Article : Google Scholar : PubMed/NCBI

15 

Shay JW: Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6:584–593. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Günes C and Rudolph KL: The role of telomeres in stem cells and cancer. Cell. 152:390–393. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Harley CB and Villeponteau B: Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev. 5:249–255. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Artandi SE and DePinho RA: Telomeres and telomerase in cancer. Carcinogenesis. 31:9–18. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Cesare AJ and Reddel RR: Alternative lengthening of telomeres: Models, mechanisms and implications. Nat Rev Genet. 11:319–330. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Heaphy CM, Subhawong AP, Hong SM, Goggins MG, Montgomery EA, Gabrielson E, Netto GJ, Epstein JI, Lotan TL, Westra WH, et al: Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol. 179:1608–1615. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Sidaway P: Sarcoma: Genetic determinants of sarcoma risk revealed. Nat Rev Clin Oncol. 13:5902016. View Article : Google Scholar

22 

Thomas DM and Ballinger ML: Diagnosis and management of hereditary sarcoma. Recent Results Cancer Res. 205:169–189. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Ballinger ML, Goode DL, Ray-Coquard I, James PA, Mitchell G, Niedermayr E, Puri A, Schiffman JD, Dite GS, Cipponi A, et al: Monogenic and polygenic determinants of sarcoma risk: An international genetic study. Lancet Oncol. 17:1261–1271. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Antonescu CR: The role of genetic testing in soft tissue sarcoma. Histopathology. 48:13–21. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Bridge JA: The role of cytogenetics and molecular diagnostics in the diagnosis of soft-tissue tumors. Mod Pathol. 27 Suppl 1:S80–S97. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Rosenberg AE: WHO classification of soft tissue and bone, fourth edition: Summary and commentary. Curr Opin Oncol. 25:571–573. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zambo I and Veselý K: WHO classification of tumours of soft tissue and bone 2013: The main changes compared to the 3rd edition. Cesk Patol. 50:64–70. 2014.PubMed/NCBI

28 

Ji J, Quindipan C, Parham D, Shen L, Ruble D, Bootwalla M, Maglinte DT, Gai X, Saitta SC, Biegel JA and Mascarenhas L: Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma. Am J Med Genet A. 173:1390–1395. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Smolle MA, Heitzer E, Geigl JB, Al Kaissi A, Liegl-Atzwanger B, Seidel MG, Holzer LA and Leithner A: A novel mutation in ATRX associated with intellectual disability, syndromic features, and osteosarcoma. Pediatr Blood Cancer. 64:e265222017. View Article : Google Scholar

30 

Liau JY, Lee JC, Tsai JH, Yang CY, Liu TL, Ke ZL, Hsu HH and Jeng YM: Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas. Mod Pathol. 28:1545–1554. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Kovac M, Blattmann C, Ribi S, Smida J, Mueller NS, Engert F, Castro-Giner F, Weischenfeldt J, Kovacova M, Krieg A, et al: Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency. Nat Commun. 6:89402015. View Article : Google Scholar : PubMed/NCBI

32 

Liau JY, Tsai JH, Jeng YM, Lee JC, Hsu HH and Yang CY: Leiomyosarcoma with alternative lengthening of telomeres is associated with aggressive histologic features, loss of ATRX expression, and poor clinical outcome. Am J Surg Pathol. 39:236–244. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chen X, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E, Ellison D, Shurtleff S, Wu G, Wei L, et al: Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep. 7:104–112. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Lee PJ, Yoo NS, Hagemann IS, Pfeifer JD, Cottrell CE, Abel HJ and Duncavage EJ: Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing. Exp Mol Pathol. 102:156–161. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Mäkinen N, Aavikko M, Heikkinen T, Taipale M, Taipale J, Koivisto-Korander R, Bützow R and Vahteristo P: Exome sequencing of uterine leiomyosarcomas identifies frequent mutations in TP53, ATRX, and MED12. PLoS Genet. 12:e10058502016. View Article : Google Scholar : PubMed/NCBI

36 

Yang CY, Liau JY, Huang WJ, Chang YT, Chang MC, Lee JC, Tsai JH, Su YN, Hung CC and Jeng YM: Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma. Am J Transl Res. 7:2072–2081. 2015.PubMed/NCBI

37 

Hartmann C, Meyer J, Balss J, Capper D, Mueller W, Christians A, Felsberg J, Wolter M, Mawrin C, Wick W, et al: Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: A study of 1,010 diffuse gliomas. Acta Neuropathol. 118:469–474. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Cleven AHG, Suijker J, Agrogiannis G, Briaire-de Bruijn IH, Frizzell N, Hoekstra AS, Wijers-Koster PM, Cleton-Jansen AM and Bovée JVMG: IDH1 or −2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. Clin Sarcoma Res. 7:82017. View Article : Google Scholar : PubMed/NCBI

39 

Johnson JE, Varkonyi RJ, Schwalm J, Cragle R, Klein-Szanto A, Patchefsky A, Cukierman E, von Mehren M and Broccoli D: Multiple mechanisms of telomere maintenance exist in liposarcomas. Clin Cancer Res. 11:5347–5355. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Lee JC, Jeng YM, Liau JY, Tsai JH, Hsu HH and Yang CY: Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas. Mod Pathol. 28:1064–1073. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Venturini L, Motta R, Gronchi A, Daidone M and Zaffaroni N: Prognostic relevance of ALT-associated markers in liposarcoma: A comparative analysis. BMC Cancer. 10:2542010. View Article : Google Scholar : PubMed/NCBI

42 

Liau JY, Tsai JH, Yang CY, Lee JC, Liang CW, Hsu HH and Jeng YM: Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas. Hum Pathol. 46:1360–1366. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Willems SM, Debiec-Rychter M, Szuhai K, Hogendoorn PC and Sciot R: Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol. 19:407–416. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Hechtman JF, Zehir A, Mitchell T, Borsu L, Singer S, Tap W, Oultache A, Ladanyi M and Nafa K: Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing. Genes Chromosomes Cancer. 54:177–184. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Napier CE, Huschtscha LI, Harvey A, Bower K, Noble JR, Hendrickson EA and Reddel RR: ATRX represses alternative lengthening of telomeres. Oncotarget. 6:16543–16558. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, et al: Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 347:273–277. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Deeg KI, Chung I, Bauer C and Rippe K: Cancer cells with alternative lengthening of telomeres do not display a general hypersensitivity to ATR inhibition. Front Oncol. 6:1862016. View Article : Google Scholar : PubMed/NCBI

48 

McFarlane S and Preston CM: Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX. Virus Res. 157:47–53. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Kovatcheva M, Liu DD, Dickson MA, Klein ME, O'Connor R, Wilder FO, Socci ND, Tap WD, Schwartz GK, Singer S, et al: MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget. 6:8226–8243. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren X, Tu C, Tang Z, Ma R and Li Z: Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review). Oncol Lett 15: 7489-7496, 2018.
APA
Ren, X., Tu, C., Tang, Z., Ma, R., & Li, Z. (2018). Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review). Oncology Letters, 15, 7489-7496. https://doi.org/10.3892/ol.2018.8318
MLA
Ren, X., Tu, C., Tang, Z., Ma, R., Li, Z."Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)". Oncology Letters 15.5 (2018): 7489-7496.
Chicago
Ren, X., Tu, C., Tang, Z., Ma, R., Li, Z."Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)". Oncology Letters 15, no. 5 (2018): 7489-7496. https://doi.org/10.3892/ol.2018.8318
Copy and paste a formatted citation
x
Spandidos Publications style
Ren X, Tu C, Tang Z, Ma R and Li Z: Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review). Oncol Lett 15: 7489-7496, 2018.
APA
Ren, X., Tu, C., Tang, Z., Ma, R., & Li, Z. (2018). Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review). Oncology Letters, 15, 7489-7496. https://doi.org/10.3892/ol.2018.8318
MLA
Ren, X., Tu, C., Tang, Z., Ma, R., Li, Z."Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)". Oncology Letters 15.5 (2018): 7489-7496.
Chicago
Ren, X., Tu, C., Tang, Z., Ma, R., Li, Z."Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas (Review)". Oncology Letters 15, no. 5 (2018): 7489-7496. https://doi.org/10.3892/ol.2018.8318
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