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Article

Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells

  • Authors:
    • Jiehong Zeng
    • Zhengkai Liu
    • Shuwen Sun
    • Jianhong Xie
    • Li Cao
    • Pin Lv
    • Shengdan Nie
    • Bao Zhang
    • Bowen Xie
    • Siyuan Peng
    • Bo Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University‑Hunan Provincial People's Hospital, Changsha, Hunan 410006, P.R. China, Department of Pharmacy, Yiyang Central Hospital, Yiyang, Hunan 413000, P.R. China, Department of General Surgery, Yiyang Central Hospital, Yiyang, Hunan 413000, P.R. China, Intistute of Clinical Medical Research, The First Affiliated Hospital of Hunan Normal University‑Hunan Provincial People's Hospital, Changsha, Hunan 410006, P.R. China
  • Pages: 8681-8686
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/ol.2018.8372
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Abstract

Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN‑recruited tumor‑associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC‑9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44+ (cancer stem cells) and CD44‑ cells (non‑cancer stem cells), and medium were evaluated by western blot analysis. HCCC‑9810 cells and THP‑1 macrophages were used to detect the effects of POSTN on recruiting TAMs in vitro. The present study revealed that CD44+ cells in ICC tissues and the HCCC‑9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP‑1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC.
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Copy and paste a formatted citation
Spandidos Publications style
Zeng J, Liu Z, Sun S, Xie J, Cao L, Lv P, Nie S, Zhang B, Xie B, Peng S, Peng S, et al: Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells. Oncol Lett 15: 8681-8686, 2018.
APA
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P. ... Jiang, B. (2018). Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells. Oncology Letters, 15, 8681-8686. https://doi.org/10.3892/ol.2018.8372
MLA
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P., Nie, S., Zhang, B., Xie, B., Peng, S., Jiang, B."Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells". Oncology Letters 15.6 (2018): 8681-8686.
Chicago
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P., Nie, S., Zhang, B., Xie, B., Peng, S., Jiang, B."Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells". Oncology Letters 15, no. 6 (2018): 8681-8686. https://doi.org/10.3892/ol.2018.8372
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng J, Liu Z, Sun S, Xie J, Cao L, Lv P, Nie S, Zhang B, Xie B, Peng S, Peng S, et al: Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells. Oncol Lett 15: 8681-8686, 2018.
APA
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P. ... Jiang, B. (2018). Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells. Oncology Letters, 15, 8681-8686. https://doi.org/10.3892/ol.2018.8372
MLA
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P., Nie, S., Zhang, B., Xie, B., Peng, S., Jiang, B."Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells". Oncology Letters 15.6 (2018): 8681-8686.
Chicago
Zeng, J., Liu, Z., Sun, S., Xie, J., Cao, L., Lv, P., Nie, S., Zhang, B., Xie, B., Peng, S., Jiang, B."Tumor‑associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells". Oncology Letters 15, no. 6 (2018): 8681-8686. https://doi.org/10.3892/ol.2018.8372
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