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Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma

  • Authors:
    • Xiao‑Lu Ma
    • Jing Zhu
    • Jiong Wu
    • Lu Tian
    • Yao‑Yi Gao
    • Chun‑Yan Zhang
    • Yan Zhou
    • Qian Dai
    • Bei‑Li Wang
    • Bai‑Shen Pan
    • Jian Zhou
    • Jia Fan
    • Xin‑Rong Yang
    • Wei Guo

  • View Affiliations

  • Published online on: March 29, 2018     https://doi.org/10.3892/ol.2018.8375
  • Pages: 8396-8404

  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to determine the levels of prothrombin induced by vitamin K absence‑II (PIVKA‑II) according to the Barcelona Clinic Liver Cancer (BCLC) staging system, to develop an appropriate strategy for managing hepatocellular carcinoma (HCC), particularly early HCC, and to investigate the value of PIVKA‑II for predicting prognosis‑associated pathological parameters. Clinical information of 117 patients with hepatitis B‑associated HCC was retrospectively collected. Preoperative serum PIVKA‑II and α‑fetoprotein (AFP) levels were measured using a chemiluminescence method. The efficiency of PIVKA‑II levels for predicting pathological parameters was evaluated using step‑wise logistic regression. The receiver operator characteristic curve was used to evaluate the predictive performance of PIVKA‑II levels. It was demonstrated that except for the difference between stages B and C HCC (P=0.923), serum PIVKA‑II levels significantly increased according to BCLC stage (P<0.050), however AFP levels did not. In early HCC (stage 0+A), the correlation between PIVKA‑II and AFP levels (dual‑positive, 64.70% in stage 0; 46.97% in stage A) was relatively weak (r=0.410). PIVKA‑II >40 mAU/ml was an independent predictor of microvascular invasion [hazard ratio (HR), 3.77; 95% confidence interval (CI), 1.31‑10.88; P=0.014; and high Ki67 expression in situ (HR, 2.99; 95% CI, 1.19‑7.52; P=0.020). Combined analysis of PIVKA and AFP levels may contribute to an effective strategy for the management of patients with early HCC, as high PIVKA‑II levels indicated a more aggressive tumor phenotype. Further investigation of PIVKA‑II levels may provide novel insights into the mechanism underlying the metastasis of HCC cells and facilitate the development of novel therapeutic strategies for HCC.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ma XL, Zhu J, Wu J, Tian L, Gao YY, Zhang CY, Zhou Y, Dai Q, Wang BL, Pan BS, Pan BS, et al: Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma. Oncol Lett 15: 8396-8404, 2018
APA
Ma, X., Zhu, J., Wu, J., Tian, L., Gao, Y., Zhang, C. ... Guo, W. (2018). Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma. Oncology Letters, 15, 8396-8404. https://doi.org/10.3892/ol.2018.8375
MLA
Ma, X., Zhu, J., Wu, J., Tian, L., Gao, Y., Zhang, C., Zhou, Y., Dai, Q., Wang, B., Pan, B., Zhou, J., Fan, J., Yang, X., Guo, W."Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma". Oncology Letters 15.6 (2018): 8396-8404.
Chicago
Ma, X., Zhu, J., Wu, J., Tian, L., Gao, Y., Zhang, C., Zhou, Y., Dai, Q., Wang, B., Pan, B., Zhou, J., Fan, J., Yang, X., Guo, W."Significance of PIVKA‑II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus‑associated hepatocellular carcinoma". Oncology Letters 15, no. 6 (2018): 8396-8404. https://doi.org/10.3892/ol.2018.8375