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Article

Endoscopic analysis of colorectal serrated lesions with cancer

  • Authors:
    • Shuichiro Nagata
    • Keiichi Mitsuyama
    • Hiroshi Kawano
    • Tetsuhiro Noda
    • Yasuhiko Maeyama
    • Michita Mukasa
    • Hidetoshi Takedatsu
    • Shinichiro Yoshioka
    • Kotaro Kuwaki
    • Jun Akiba
    • Osamu Tsuruta
    • Takuji Torimura
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Gastroenterology, St. Mary's Hospital, Kurume, Fukuoka 830‑8543, Japan, Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan
  • Pages: 8655-8662
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/ol.2018.8386
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Abstract

Serrated lesions, including hyperplastic polyps (HPs), traditional serrated adenomas (TSAs) and sessile serrated adenomas/polyps (SSA/Ps), are important contributors to colorectal carcinogenesis. The aim of the present study was to analyze the potential of conventional endoscopy and advanced endoscopic imaging techniques to delineate the characteristic features of serrated lesions with cancer. The present study was a retrospective analysis of the data of 168 patients who had undergone colonoscopy, and a total of 228 serrated lesions (77 HPs, 58 TSAs, 84 SSA/Ps, 9 SSA/P plus TSAs) have been identified in these patients. A cancer component was identified in 2.6% of HPs, 13.8% of TSAs and 10.7% of SSA/Ps, but none of SSA/P plus TSAs. Compared with the lesions without cancer, the lesions with cancer exhibited a larger size (HP, TSA and SSA/P), a reddish appearance (SSA/P), a two‑tier raised appearance (HP and SSA/P), a central depression (HP, TSA and SSA/P), the type V pit pattern (HP, TSA and SSA/P), and/or the type III capillary pattern (TSA and SSA/P). Deep invasion was identified in 50.0% of HPs, 12.5% of TSAs and 55.6% of SSA/Ps with cancer. The Ki‑67 proliferative zone was distributed diffusely within the area of the cancer, but partially within the non‑cancer area of HPs, TSAs and SSA/Ps. The lesion types were also analyzed on the basis of mucin phenotype. The present study suggested that a detailed endoscopic analysis of serrated lesions with cancer is useful for delineating characteristic features, and the analysis aids treatment selection.
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Copy and paste a formatted citation
Spandidos Publications style
Nagata S, Mitsuyama K, Kawano H, Noda T, Maeyama Y, Mukasa M, Takedatsu H, Yoshioka S, Kuwaki K, Akiba J, Akiba J, et al: Endoscopic analysis of colorectal serrated lesions with cancer. Oncol Lett 15: 8655-8662, 2018.
APA
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M. ... Torimura, T. (2018). Endoscopic analysis of colorectal serrated lesions with cancer. Oncology Letters, 15, 8655-8662. https://doi.org/10.3892/ol.2018.8386
MLA
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M., Takedatsu, H., Yoshioka, S., Kuwaki, K., Akiba, J., Tsuruta, O., Torimura, T."Endoscopic analysis of colorectal serrated lesions with cancer". Oncology Letters 15.6 (2018): 8655-8662.
Chicago
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M., Takedatsu, H., Yoshioka, S., Kuwaki, K., Akiba, J., Tsuruta, O., Torimura, T."Endoscopic analysis of colorectal serrated lesions with cancer". Oncology Letters 15, no. 6 (2018): 8655-8662. https://doi.org/10.3892/ol.2018.8386
Copy and paste a formatted citation
x
Spandidos Publications style
Nagata S, Mitsuyama K, Kawano H, Noda T, Maeyama Y, Mukasa M, Takedatsu H, Yoshioka S, Kuwaki K, Akiba J, Akiba J, et al: Endoscopic analysis of colorectal serrated lesions with cancer. Oncol Lett 15: 8655-8662, 2018.
APA
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M. ... Torimura, T. (2018). Endoscopic analysis of colorectal serrated lesions with cancer. Oncology Letters, 15, 8655-8662. https://doi.org/10.3892/ol.2018.8386
MLA
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M., Takedatsu, H., Yoshioka, S., Kuwaki, K., Akiba, J., Tsuruta, O., Torimura, T."Endoscopic analysis of colorectal serrated lesions with cancer". Oncology Letters 15.6 (2018): 8655-8662.
Chicago
Nagata, S., Mitsuyama, K., Kawano, H., Noda, T., Maeyama, Y., Mukasa, M., Takedatsu, H., Yoshioka, S., Kuwaki, K., Akiba, J., Tsuruta, O., Torimura, T."Endoscopic analysis of colorectal serrated lesions with cancer". Oncology Letters 15, no. 6 (2018): 8655-8662. https://doi.org/10.3892/ol.2018.8386
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