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Article

Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma

  • Authors:
    • Ana Isabel Plano Sánchez
    • Lucía Velasco Roces
    • Isabel Zapico García
    • Eva Lázaro López
    • Miguel Angel Calleja Hernandez
    • Maria Isabel Baena Parejo
    • Jaime Peña‑Díaz
  • View Affiliations / Copyright

    Affiliations: Hospital Pharmacy Department, Central University Hospital of Asturias, Oviedo, 33011 Asturias, Spain, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
  • Pages: 8863-8870
    |
    Published online on: March 30, 2018
       https://doi.org/10.3892/ol.2018.8400
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Abstract

Sorafenib is an oral multikinase inhibitor with antiangiogenic and antiproliferative properties, and is used as the first‑line treatment for patients with advanced hepatocellular carcinoma (HCC). Previous studies have identified an improvement in overall survival and progression‑free survival in patients with a manageable toxicity profile. α‑fetoprotein (AFP) has been revealed to be of great diagnostic and predictive value for tumour staging in multiple studies; however, its role as a predictive factor of response to treatment with sorafenib is not entirely clear. The present study aimed to determine the effectiveness of sorafenib and investigate the value of AFP as a predictive factor of early response to sorafenib in patients with HCC. Effectiveness was analysed based on median overall survival (mOS) time, while to analyse the possible predictive value of AFP, patients were classified into two groups: Non‑responders (≤20% AFP reduction) and responders (>20% AFP reduction) at 6‑8 weeks of treatment when compared with basal AFP level. For assessment of toxicity, any adverse effects were recorded. A total of 167 patients were included, who collectively exhibited a mOS time of 11 months with a median treatment duration of 5 months. The mOS time was significantly higher for patients with better hepatic function (12 months in cases of Child‑Pugh score A vs. 8 months in cases of Child‑Pugh score B; P=0.03) and with basal AFP values ≤200 ng/ml (14 months vs. 8 months in patients with AFP levels >200 ng/ml; P=0.01). A >20% reduction of AFP at 6‑8 weeks was determined to be a positive predictive factor upon multivariate analysis (P=0.002), obtaining, for the responder patients, an mOS of 18 months compared with 10 months (P=0.004) for the non‑responders. The main adverse reactions were hand‑foot syndrome (35/167; 21%), diarrhoea (39/167; 23.4%), anorexia (29/167; 17.4%) and arterial hypertension (30/167; 18%). In conclusion, a >20% drop in AFP at 6‑8 weeks may be useful as a predictive factor of response to sorafenib, as indicated by its association with longer survival times in patients with advanced HCC following treatment with sorafenib in the present study.
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1 

International Agency for Research on Cancer (IARC): Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/Default.aspxApril 10–2015

2 

Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Mittal S and El-Serag HB: Epidemiology of hepatocellular carcinoma: Consider the population. J Clin Gastroenterol. 47:S2–S6. 2013. View Article : Google Scholar : PubMed/NCBI

4 

European Association for the Study of The Liver; European Organisation for Research and Treatment of Cancer: EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 56:908–943. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, Tateishi R, Han KH, Chawla YK, Shiina S, et al: Asia-pacific clinical practice guidelines on the management of hepatocellular carcinoma: A 2017 update. Hepatol Int. 11:317–370. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Reig M, Matilla A, Bustamante J, Castells L, de La Mata M, Delgado M, Moreno JM, Forner A and Varela M: Recommendations for the management of Sorafenib in patients with hepatocellular carcinoma. Gastroenterol Hepatol. 33:741–752. 2010.(In Spanish). View Article : Google Scholar : PubMed/NCBI

7 

Bruix J and Sherman M: American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma: An update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al: Efficacy and safety of sorafenib in patients in the asia-pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Llovet JM and Bruix J: Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology. 37:429–442. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Dawson LA: The evolving role of radiation therapy in hepatocellular carcinoma. Cancer Radiother. 12:96–101. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Han KH, Seong J, Kim JK, Ahn SH, Lee DY and Chon CY: Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis. Cancer. 113:995–1003. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Colagrande S, Regini F, Taliani GG, Nardi C and Inghilesi AL: Advanced hepatocellular carcinoma and sorafenib: Diagnosis, indications, clinical and radiological follow-up. World J Hepatol. 7:1041–1053. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Lencioni R and Llovet JM: Modified recist (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 30:52–60. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kawaoka T, Aikata H, Murakami E, Nakahara T, Naeshiro N, Tanaka M, Honda Y, Miyaki D, Nagaoki Y, Takaki S, et al: Evaluation of the mrecist and α-fetoprotein ratio for stratification of the prognosis of advanced-hepatocellular-carcinoma patients treated with sorafenib. Oncology. 83:192–200. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Takada J, Hidaka H, Nakazawa T, Kondo M, Numata K, Tanaka K, Matsunaga K, Okuse C, Kobayashi S, Morimoto M, et al: Modified response evaluation criteria in solid tumors is superior to response evaluation criteria in solid tumors for assessment of responses to sorafenib in patients with advanced hepatocellular carcinoma. BMC Res Notes. 8:6092015. View Article : Google Scholar : PubMed/NCBI

17 

Yau T, Yao TJ, Chan P, Wong H, Pang R, Fan ST and Poon RT: The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib. Oncologist. 16:1270–1279. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Nomura F, Ohnishi K and Tanabe Y: Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients. Cancer. 64:1700–1707. 1989. View Article : Google Scholar : PubMed/NCBI

19 

Matsumoto Y, Suzuki T, Ono H, Nakase A and Honjo I: Evaluation of hepatoma chemotherapy by alpha-fetoprotein determination. Am J Surg. 132:325–328. 1976. View Article : Google Scholar : PubMed/NCBI

20 

Chan SL, Mo FK, Johnson PJ, Hui EP, Ma BB, Ho WM, Lam KC, Chan AT, Mok TS and Yeo W: New utility of an old marker: Serial alpha-fetoprotein measurement in predicting radiologic response and survival of patients with hepatocellular carcinoma undergoing systemic chemotherapy. J Clin Oncol. 27:446–452. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Personeni N, Bozzarelli S, Pressiani T, Rimassa L, Tronconi MC, Sclafani F, Carnaghi C, Pedicini V, Giordano L and Santoro A: Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma. J Hepatol. 57:101–107. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Liu L, Zhao Y, Jia J, Chen H, Bai W, Yang M, Yin Z, He C, Zhang L, Guo W, et al: The prognostic value of alpha-fetoprotein response for advanced-stage hepatocellular carcinoma treated with sorafenib combined with transarterial chemoembolization. Sci Rep. 6:198512016. View Article : Google Scholar : PubMed/NCBI

23 

Okuyama H, Ikeda M, Kuwahara A, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Senda S and Okusaka T: Prognostic factors in patients with hepatocellular carcinoma refractory or intolerant to sorafenib. Oncology. 88:241–246. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Bruix J, Raoul JL, Sherman M, Mazzaferro V, Bolondi L, Craxi A, Galle PR, Santoro A, Beaugrand M, Sangiovanni A, et al: Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial. J Hepatol. 57:821–829. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Iavarone M, Cabibbo G, Piscaglia F, Zavaglia C, Grieco A, Villa E, Cammà C and Colombo M: SOFIA (SOraFenib Italian Assessment) study group: Field-practice study of sorafenib therapy for hepatocellular carcinoma: A prospective multicenter study in Italy. Hepatology. 54:2055–2063. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Kudo M, Imanaka K, Chida N, Nakachi K, Tak WY, Takayama T, Yoon JH, Hori T, Kumada H, Hayashi N, et al: Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma. Eur J Cancer. 47:2117–2127. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Køstner AH, Sorensen M, Olesen RK, Grønbæk H, Lassen U and Ladekarl M: Sorafenib in advanced hepatocellular carcinoma: A nationwide retrospective study of efficacy and tolerability. ScientificWorldJournal. 2013:9319722013. View Article : Google Scholar : PubMed/NCBI

28 

DA Fonseca LG, Barroso-Sousa R, Bento AD, Blanco BP, Valente GL, Pfiffer TE, Hoff PM and Sabbaga J: Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma. Mol Clin Oncol. 3:793–796. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Nakano M, Tanaka M, Kuromatsu R, Nagamatsu H, Tajiri N, Satani M, Niizeki T, Aino H, Okamura S, Iwamoto H, et al: Kurume liver cancer study group of japan. sorafenib for the treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: A prospective multicenter cohort study. Cancer Med. 4:1836–1843. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Wang Z, Wu XL, Zeng WZ, Xu GS, Xu H, Weng M, Hou JN and Jiang MD: Meta-analysis of the efficacy of sorafenib for hepatocellular carcinoma. Asian Pac J Cancer Prev. 14:691–694. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Shao YY, Lin ZZ, Hsu C, Shen YC, Hsu CH and Cheng AL: Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma. Cancer. 116:4590–4596. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Raoul JL, Bruix J, Greten TF, Sherman M, Mazzaferro V, Hilgard P, Scherubl H, Scheulen ME, Germanidis G, Dominguez S, et al: Relationship between baseline hepatic status and outcome, and effect of sorafenib on liver function: SHARP trial subanalyses. J Hepatol. 56:1080–1088. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Lee S, Kim BK, Kim SU, Park SY, Kim JK, Lee HW, Park JY, Kim DY, Ahn SH, Tak WY, et al: Clinical outcomes and prognostic factors of patients with advanced hepatocellular carcinoma treated with sorafenib as first-line therapy: A korean multicenter study. J Gastroenterol Hepatol. 29:1463–1469. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Chen LT, Liu TW, Chao Y, Shiah HS, Chang JY, Juang SH, Chen SC, Chuang TR, Chin YH and Whang-Peng J: Alpha-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma. Aliment Pharmacol Ther. 22:217–226. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Raoul JL, Park JW, Kang YK, Finn RS, Kim JS, Yeo W, Polite BN, Chao Y, Walters I, Baudelet C and Lencioni R: Using modified recist and alpha-fetoprotein levels to assess treatment benefit in hepatocellular carcinoma. Liver Cancer. 3:439–450. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Chou WC, Lee CL, Yang TS, Huang CY, Teng W, Tseng YT, Chen JS, Lin YC, Hou MM, Chang HH and Hsieh Chia-Hsun J: Changes in serum α-fetoprotein level predicts treatment response and survival in hepatocellular carcinoma patients and literature review. J Formos Med Assoc. 117:153–163. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Xu XS, Qu K, Liu C, Zhang YL, Liu J, Song YZ, Zhang P, Liu SN and Chang HL: Highlights for α-fetoprotein in determining prognosis and treatment monitoring for hepatocellular carcinoma. World J Gastroenterol. 18:7242–7250. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Plano Sánchez AI, Velasco Roces L, Zapico García I, Lázaro López E, Calleja Hernandez MA, Baena Parejo MI and Peña‑Díaz J: Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma. Oncol Lett 15: 8863-8870, 2018.
APA
Plano Sánchez, A.I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M.A., Baena Parejo, M.I., & Peña‑Díaz, J. (2018). Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma. Oncology Letters, 15, 8863-8870. https://doi.org/10.3892/ol.2018.8400
MLA
Plano Sánchez, A. I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M. A., Baena Parejo, M. I., Peña‑Díaz, J."Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma". Oncology Letters 15.6 (2018): 8863-8870.
Chicago
Plano Sánchez, A. I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M. A., Baena Parejo, M. I., Peña‑Díaz, J."Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma". Oncology Letters 15, no. 6 (2018): 8863-8870. https://doi.org/10.3892/ol.2018.8400
Copy and paste a formatted citation
x
Spandidos Publications style
Plano Sánchez AI, Velasco Roces L, Zapico García I, Lázaro López E, Calleja Hernandez MA, Baena Parejo MI and Peña‑Díaz J: Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma. Oncol Lett 15: 8863-8870, 2018.
APA
Plano Sánchez, A.I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M.A., Baena Parejo, M.I., & Peña‑Díaz, J. (2018). Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma. Oncology Letters, 15, 8863-8870. https://doi.org/10.3892/ol.2018.8400
MLA
Plano Sánchez, A. I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M. A., Baena Parejo, M. I., Peña‑Díaz, J."Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma". Oncology Letters 15.6 (2018): 8863-8870.
Chicago
Plano Sánchez, A. I., Velasco Roces, L., Zapico García, I., Lázaro López, E., Calleja Hernandez, M. A., Baena Parejo, M. I., Peña‑Díaz, J."Value of α‑fetoprotein as an early biomarker for treatment response to sorafenib therapy in advanced hepatocellular carcinoma". Oncology Letters 15, no. 6 (2018): 8863-8870. https://doi.org/10.3892/ol.2018.8400
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