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∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer

  • Authors:
    • Yingzhi Zhang
    • Wei Zheng
    • Kewei Shen
    • Weiwei Shen
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Gynecology, The Affiliated Hospital of School of Medicine of Ningbo University, Hangzhou, Zhejiang 310058, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8527-8535
    |
    Published online on: April 2, 2018
       https://doi.org/10.3892/ol.2018.8407
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Abstract

Limited therapeutic interventions are clinically available for treating aggressive endometrial cancer (EC). Therefore, effective therapies are urgently required. Therefore, the present study investigated the role of ∆9‑tetrahydrocannabinol (THC), which is reported to impact proliferative and migratory activities during impairment of cancer progression. In the present study, cell migration in response to THC was measured using transwell assays. Using western blot analysis, the levels of cannabinoid receptors in EC tissues were detected and pathways leading to the inhibition of cell migration by THC on human EC cells were determined. Results suggested that cannabinoid receptors were highly expressed in EC tissues. Furthermore, THC inhibited EC cell viability and motility by inhibiting epithelial‑mesenchymal transition (EMT) and downregulating matrix metalloproteinase‑9 (MMP‑9) gene expression in aggressive human EC cells. The results have the potential to promote the development of novel compounds for the treatment of EC metastasis. The presnet findings suggest that THC may inhibit human EC cell migration through regulating EMT and MMP‑9 pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zheng W, Shen K and Shen W: ∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer. Oncol Lett 15: 8527-8535, 2018.
APA
Zhang, Y., Zheng, W., Shen, K., & Shen, W. (2018). ∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer. Oncology Letters, 15, 8527-8535. https://doi.org/10.3892/ol.2018.8407
MLA
Zhang, Y., Zheng, W., Shen, K., Shen, W."∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer". Oncology Letters 15.6 (2018): 8527-8535.
Chicago
Zhang, Y., Zheng, W., Shen, K., Shen, W."∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer". Oncology Letters 15, no. 6 (2018): 8527-8535. https://doi.org/10.3892/ol.2018.8407
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zheng W, Shen K and Shen W: ∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer. Oncol Lett 15: 8527-8535, 2018.
APA
Zhang, Y., Zheng, W., Shen, K., & Shen, W. (2018). ∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer. Oncology Letters, 15, 8527-8535. https://doi.org/10.3892/ol.2018.8407
MLA
Zhang, Y., Zheng, W., Shen, K., Shen, W."∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer". Oncology Letters 15.6 (2018): 8527-8535.
Chicago
Zhang, Y., Zheng, W., Shen, K., Shen, W."∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer". Oncology Letters 15, no. 6 (2018): 8527-8535. https://doi.org/10.3892/ol.2018.8407
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