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Case Report Open Access

Cronkhite‑Canada syndrome: A case report

  • Authors:
    • Wei Yuan
    • Li Tian
    • Fei‑Yan Ai
    • Shao‑Jun Liu
    • Shou‑Rong Shen
    • Xiao‑Yan Wang
    • Fen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Hunan Key Laboratory of Non‑Resolving Inflammation and Cancer, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8447-8453
    |
    Published online on: April 2, 2018
       https://doi.org/10.3892/ol.2018.8409
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Abstract

Cronkhite‑Canada syndrome (CCS) is a rare non‑inherited condition characterized by gastrointestinal (GI) hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhea. The etiology is most likely autoimmune and diagnosis is based on patient history, physical examination, endoscopic findings of GI polyposis and histology. The disease is very rare; thus far more than 500 cases of CCS have been reported globally. A 58‑years‑old male with CCS was reported in the present case study. The patient experienced a history of diarrhea and hematochezia for 4 months, with abdominal pain for 1 month and additional nail and toenail loss for half a month. The clinical, endoscopic and histological data confirmed the diagnosis.
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1 

Sweetser S, Alexander GL and Boardman LA: A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps. Nat Rev Gastroenterol Hepatol. 7:460–464. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Goto A: Cronkhite-Canada syndrome: Epidemiological study of 110 cases reported in Japan. Nihon Geka Hokan. 64:3–14. 1995.PubMed/NCBI

3 

Ward EM and Wolfsen HC: Review article: The non-inherited gastrointestinal polyposis syndromes. Aliment Pharmacol Ther. 16:333–342. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Gardner EJ, Burt RW and Freston JW: Gastrointestinal polyposis: Syndromes and genetic mechanisms. West J Med. 132:488–499. 1980.PubMed/NCBI

5 

Rubio CA and Björk J: Cronkhite-Canada syndrome-A case report. Anticancer Res. 36:4215–4217. 2016.PubMed/NCBI

6 

Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM and Schwabe AD: The Cronkhite-Canada syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. Medicine. 61:293–309. 1982. View Article : Google Scholar : PubMed/NCBI

7 

Watanabe C, Komoto S, Tomita K, Hokari R, Tanaka M, Hirata I, Hibi T, Kaunitz JD and Miura S: Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: A Japanese nationwide survey. J Gastroenterol. 51:327–336. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yun SH, Cho JW, Kim JW, Kim JK, Park MS, Lee NE, Lee JU and Lee YJ: Cronkhite-Canada syndrome associated with serrated adenoma and malignant polyp: A case report and a literature review of 13 cronkhite-Canada syndrome cases in Korea. Clin Endosc. 463:301–305. 2013. View Article : Google Scholar

9 

Wen XH, Wang L, Wang YX and Qian JM: Cronkhite-Canada syndrome: Report of six cases and review of literature. World J Gastroenterol. 20:7518–7522. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Patil V, Patil LS, Jakareddy R, Verma A and Gupta AB: Cronkhite-Canada syndrome: A report of two familial cases. Indian J Gastroenterol. 32:119–122. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Murata I, Yoshikawa I, Endo M, Tai M, Toyoda C, Abe S, Hirano Y and Otsuki M: Cronkhite-Canada syndrome: Report of two cases. J Gastroenterol. 35:706–711. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Sweetser S, Ahlquist DA, Osborn NK, Sanderson SO, Smyrk TC, Chari ST and Boardman LA: Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: Support for autoimmunity. Dig Dis Sci. 57:496–502. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Riegert-Johnson DL, Osborn N, Smyrk T and Boardman LA: Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells. Digestion. 75:96–97. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Freeman K, Anthony PP, Miller DS and Warin AP: Cronkhite Canada syndrome: A new hypothesis. Gut. 26:531–536. 1985. View Article : Google Scholar : PubMed/NCBI

15 

Matsui S, Kibi M, Anami E, Anami T, Inagaki Y, Kanouda A, Yoshinaga H, Watanabe A, Sugahara A, Mukai H, et al: A case of Cronkhite-Canada syndrome with multiple colon adenomas and early colon cancers. Nihon Shokakibyo Gakkai Zasshi. 108:778–786. 2011.(In Japanese). PubMed/NCBI

16 

Wang J, Zhao L, Ma N, Che J, Li H and Cao B: Cronkhite-Canada syndrome associated with colon cancer metastatic to liver: A case report. Medicine (Baltimore). 968:e74662017. View Article : Google Scholar

17 

Chakrabarti S: Cronkhite-Canada syndrome (CCS)-A rare case report. J Clin Diagn Res. 9:OD08–OD09. 2015.PubMed/NCBI

18 

Goto A, Mimoto H, Shibuya C and Matsunami E: Cronkhite-Canada syndrome: An analysis of clinical features and follow-up studies of 80 cases reported in Japan. Nihon Geka Hokan. 57:506–526. 1988.PubMed/NCBI

19 

Seshadri D, Karagiorgos N and Hyser MJ: A case of cronkhite-Canada syndrome and a review of gastrointestinal polyposis syndromes. Gastroenterol Hepatol (NY). 8:197–201. 2012.

20 

Yasuda T, Ueda T, Matsumoto I, Shirasaka D, Nakajima T, Sawa H, Shinzeki M, Kim Y, Fujino Y and Kuroda Y: Cronkhite-Canada syndrome presenting as recurrent severe acute pancreatitis. Gastrointest Endosc. 67:570–572. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Takeuchi Y, Yoshikawa M, Tsukamoto N, Shiroi A, Hoshida Y, Enomoto Y, Kimura T, Yamamoto K, Shiiki H, Kikuchi E and Fukui H: Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. J Gastroenterol. 38:791–795. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Sweetser S and Boardman LA: Cronkhite-Canada syndrome: An acquired condition of gastrointestinal polyposis and dermatologic abnormalities. Gastroenterol Hepatol (NY). 8:201–203. 2012.

23 

Samet JD, Horton KM, Fishman EK and Iacobuzio-Donahue CA: Cronkhite-Canada syndrome: Gastric involvement diagnosed by MDCT. Case Rep Med. 2009:1487952009. View Article : Google Scholar : PubMed/NCBI

24 

Kopáčová M, Urban O, Cyrany J, Laco J, Bureš J, Rejchrt S, Bártová J and Tachecí I: Cronkhite-Canada syndrome: Review of the literature. Gastroenterol Res Pract. 2013:8568732013. View Article : Google Scholar : PubMed/NCBI

25 

Iqbal U, Chaudhary A, Karim MA, Anwar H and Merrell N: Cronkhite-Canada syndrome: A rare cause of chronic diarrhea. Gastroenterology Res. 10:196–198. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Fan RY, Wang XW, Xue LJ, An R and Sheng JQ: Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells. World J Clin Cases. 4:248–252. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan W, Tian L, Ai FY, Liu SJ, Shen SR, Wang XY and Liu F: Cronkhite‑Canada syndrome: A case report. Oncol Lett 15: 8447-8453, 2018.
APA
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., & Liu, F. (2018). Cronkhite‑Canada syndrome: A case report. Oncology Letters, 15, 8447-8453. https://doi.org/10.3892/ol.2018.8409
MLA
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., Liu, F."Cronkhite‑Canada syndrome: A case report". Oncology Letters 15.6 (2018): 8447-8453.
Chicago
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., Liu, F."Cronkhite‑Canada syndrome: A case report". Oncology Letters 15, no. 6 (2018): 8447-8453. https://doi.org/10.3892/ol.2018.8409
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan W, Tian L, Ai FY, Liu SJ, Shen SR, Wang XY and Liu F: Cronkhite‑Canada syndrome: A case report. Oncol Lett 15: 8447-8453, 2018.
APA
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., & Liu, F. (2018). Cronkhite‑Canada syndrome: A case report. Oncology Letters, 15, 8447-8453. https://doi.org/10.3892/ol.2018.8409
MLA
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., Liu, F."Cronkhite‑Canada syndrome: A case report". Oncology Letters 15.6 (2018): 8447-8453.
Chicago
Yuan, W., Tian, L., Ai, F., Liu, S., Shen, S., Wang, X., Liu, F."Cronkhite‑Canada syndrome: A case report". Oncology Letters 15, no. 6 (2018): 8447-8453. https://doi.org/10.3892/ol.2018.8409
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