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Article

Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins

  • Authors:
    • Yateng Tie
    • Chong Chen
    • Yanli Yang
    • Zhen Qian
    • Hang Yuan
    • Huan Wang
    • Haili Tang
    • Yao Peng
    • Xilin Du
    • Bin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Lanzhou General Hospital of the People's Liberation Army, Lanzhou, Gansu 730050, P.R. China, Department of Neurosurgery, 451st Central Hospital of the People's Liberation Army, Xi'an, Shaanxi 710054, P.R. China, Department of Pathology, Tianjin Children's Hospital, Tianjin 300134, P.R. China, Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 8695-8702
    |
    Published online on: April 2, 2018
       https://doi.org/10.3892/ol.2018.8410
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Abstract

Colorectal cancer (CRC) is one of the most frequently occurring primary malignant tumors worldwide. Chemotherapeutic resistance is a major clinical problem in the treatment of CRC. Therefore, it is of great importance to investigate novel biomarkers that may predict chemoresistance and facilitate the development of individualized treatment for patients with CRC. The present study reported that let‑7f‑5p expression was elevated in chemotherapy‑resistant CRC tissues compared with chemotherapy‑sensitive tissues. Furthermore, upregulating let‑7f‑5p increased the expression levels of the anti‑apoptotic proteins, B‑cell lymphoma 2 (Bcl‑2) and B‑cell lymphoma‑extra large (Bcl‑xL), and decreased the activity of caspase‑3 and caspase‑9 in CRC cells. By contrast, downregulating let‑7f‑5p yielded the opposite effect. Notably, the results indicated that let‑7f‑5p promoted chemotherapeutic resistance by directly repressing the expression of several pro‑apoptotic proteins, including tumor protein p53, tumor protein p53‑inducible nuclear protein 1, tumor protein p53‑inducible nuclear protein 2 and caspase‑3. Therefore, a novel mechanism by which let‑7f‑5p enhances the resistance of CRC cells to chemotherapeutics has been revealed, indicating that silencing let‑7f‑5p may become an effective therapeutic strategy against CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Tie Y, Chen C, Yang Y, Qian Z, Yuan H, Wang H, Tang H, Peng Y, Du X, Liu B, Liu B, et al: Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins. Oncol Lett 15: 8695-8702, 2018.
APA
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H. ... Liu, B. (2018). Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins. Oncology Letters, 15, 8695-8702. https://doi.org/10.3892/ol.2018.8410
MLA
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H., Tang, H., Peng, Y., Du, X., Liu, B."Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins". Oncology Letters 15.6 (2018): 8695-8702.
Chicago
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H., Tang, H., Peng, Y., Du, X., Liu, B."Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins". Oncology Letters 15, no. 6 (2018): 8695-8702. https://doi.org/10.3892/ol.2018.8410
Copy and paste a formatted citation
x
Spandidos Publications style
Tie Y, Chen C, Yang Y, Qian Z, Yuan H, Wang H, Tang H, Peng Y, Du X, Liu B, Liu B, et al: Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins. Oncol Lett 15: 8695-8702, 2018.
APA
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H. ... Liu, B. (2018). Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins. Oncology Letters, 15, 8695-8702. https://doi.org/10.3892/ol.2018.8410
MLA
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H., Tang, H., Peng, Y., Du, X., Liu, B."Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins". Oncology Letters 15.6 (2018): 8695-8702.
Chicago
Tie, Y., Chen, C., Yang, Y., Qian, Z., Yuan, H., Wang, H., Tang, H., Peng, Y., Du, X., Liu, B."Upregulation of let‑7f‑5p promotes chemotherapeutic resistance in colorectal cancer by directly repressing several pro‑apoptotic proteins". Oncology Letters 15, no. 6 (2018): 8695-8702. https://doi.org/10.3892/ol.2018.8410
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