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FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis

  • Authors:
    • Shinan Chen
    • Yan Qiu
    • Peng Guo
    • Tianjie Pu
    • Ye Feng
    • Hong Bu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8206-8214
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    Published online on: April 4, 2018
       https://doi.org/10.3892/ol.2018.8423
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Abstract

Human epidermal growth factor receptor 1 or 2 (HER1/2), and fibroblast growth factor receptor 1 (FGFR1) signaling serve critical roles in the progression of breast cancer; however, cross‑talk between HER1/2 and FGFR1 signaling has not been extensively studied. In the present study, the copy number variation status of FGFR1 and HER1/2, and the clinical implications and prognostic relevance of this, were evaluated in invasive ductal breast cancer (IDC) tissue samples. Quantitative polymerase chain reaction and fluorescence in situ hybridization were used to assess gene copy number variation in IDC samples, and the clinical characteristics and survival curves of patients with IDC were analyzed. The amplification of FGFR1 was identified in 16.0% of the samples (12 of 75), of HER1 in 26.7% (20 of 75), of HER2 in 37.3% (28 of 75), and of FGFR1 and HER1/2 simultaneously in 8.0% (6 of 75). FGFR1 and HER1/2 co‑amplification were significantly correlated with distant metastasis (P=0.035), recurrence (P=0.026) and decreased disease‑free survival time (P=0.042). This was the case for patients undergoing endocrine therapy (P=0.002) and chemotherapy (P=0.044). Taken together, the results indicate that patients with FGFR1 and HER1/2 co‑amplification may exhibit a less favorable prognosis compared with patients with either FGFR1, HER1/2 amplification or without amplification.
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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Qiu Y, Guo P, Pu T, Feng Y and Bu H: FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis. Oncol Lett 15: 8206-8214, 2018.
APA
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., & Bu, H. (2018). FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis. Oncology Letters, 15, 8206-8214. https://doi.org/10.3892/ol.2018.8423
MLA
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., Bu, H."FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis". Oncology Letters 15.6 (2018): 8206-8214.
Chicago
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., Bu, H."FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis". Oncology Letters 15, no. 6 (2018): 8206-8214. https://doi.org/10.3892/ol.2018.8423
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Qiu Y, Guo P, Pu T, Feng Y and Bu H: FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis. Oncol Lett 15: 8206-8214, 2018.
APA
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., & Bu, H. (2018). FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis. Oncology Letters, 15, 8206-8214. https://doi.org/10.3892/ol.2018.8423
MLA
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., Bu, H."FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis". Oncology Letters 15.6 (2018): 8206-8214.
Chicago
Chen, S., Qiu, Y., Guo, P., Pu, T., Feng, Y., Bu, H."FGFR1 and HER1 or HER2 co‑amplification in breast cancer indicate poor prognosis". Oncology Letters 15, no. 6 (2018): 8206-8214. https://doi.org/10.3892/ol.2018.8423
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