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Article

The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer

  • Authors:
    • Jing‑Wei Wang
    • Xiao‑Long Wei
    • Xiao‑Wei Dou
    • Wen‑He Huang
    • Cai‑Wen Du
    • Guo‑Jun Zhang
  • View Affiliations / Copyright

    Affiliations: The Breast Center and Changjiang Scholar's Laboratory, The Cancer Hospital of Shantou University Medical College (SUMC), Shantou, Guangdong 515031, P.R. China, Cancer Research Center, SUMC, Shantou, Guangdong 515041, P.R. China
  • Pages: 8749-8755
    |
    Published online on: April 5, 2018
       https://doi.org/10.3892/ol.2018.8442
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Abstract

Notch4, a family member of the Notch signaling pathway, has important roles in cellular developmental pathways, including proliferation, differentiation and apoptosis. The present study aimed to investigate the association between Notch4 expression and clinical outcomes with immunohistochemistry. Notch4 was expressed in 55.6% of triple‑negative breast cancer (TNBC), 45.8% of Her‑2‑overexpressing and 25.5% of luminal breast cancer cases, with significantly higher expression occurring in TNBC (P<0.05). Furthermore, Notch4 expression was inversely associated with estrogen receptor (ER) and/or progesterone receptor positivity, and positively associated with larger tumor size, more lymph node involvement, and more advanced tumor node metastasis stage (P<0.05). No significant association was identified regarding age, menopausal status, Her‑2 status or distant metastasis. Univariate survival analysis revealed that patients with low Notch4‑expressing tumors exhibited a lower relative risk of cancer recurrence compared with patients with high Notch4‑expressing tumors. However, in the luminal cohort, high Notch4 expression conferred significantly lower 5‑year overall survival (OS) rates compared with Notch4 low‑expression groups (P=0.003) but not in TNBC and Her‑2‑overexpressing patients. In conclusion, Notch4 expression was significantly higher in patients with TNBC and Her‑2‑overexpressing breast cancer compared with luminal breast cancer patients. Notch4 expression is associated with aggressive clinicopathological and biological phenotypes, and may predict poor prognosis in luminal breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang JW, Wei XL, Dou XW, Huang WH, Du CW and Zhang GJ: The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer. Oncol Lett 15: 8749-8755, 2018.
APA
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., & Zhang, G. (2018). The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer. Oncology Letters, 15, 8749-8755. https://doi.org/10.3892/ol.2018.8442
MLA
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., Zhang, G."The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer". Oncology Letters 15.6 (2018): 8749-8755.
Chicago
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., Zhang, G."The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer". Oncology Letters 15, no. 6 (2018): 8749-8755. https://doi.org/10.3892/ol.2018.8442
Copy and paste a formatted citation
x
Spandidos Publications style
Wang JW, Wei XL, Dou XW, Huang WH, Du CW and Zhang GJ: The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer. Oncol Lett 15: 8749-8755, 2018.
APA
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., & Zhang, G. (2018). The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer. Oncology Letters, 15, 8749-8755. https://doi.org/10.3892/ol.2018.8442
MLA
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., Zhang, G."The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer". Oncology Letters 15.6 (2018): 8749-8755.
Chicago
Wang, J., Wei, X., Dou, X., Huang, W., Du, C., Zhang, G."The association between Notch4 expression, and clinicopathological characteristics and clinical outcomes in patients with breast cancer". Oncology Letters 15, no. 6 (2018): 8749-8755. https://doi.org/10.3892/ol.2018.8442
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