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Article

Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines

  • Authors:
    • Jun Li
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
  • Pages: 9392-9396
    |
    Published online on: April 10, 2018
       https://doi.org/10.3892/ol.2018.8458
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Abstract

The present study investigated the function of ROS proto‑oncogene 1 receptor tyrosine kinase (ROS1) in regulating the migration and proliferation of acute myeloid leukemia (AML) cells through Wnt/β‑catenin signaling, and in arsenic trioxide (ATO) treatment. The migration and proliferation of multiple ROS1‑silenced leukemic cell lines was assessed, and the expression levels of proteins associated with Wnt/β‑catenin signaling were determined using western blot analysis. Compared with the AML control cells, ROS1‑knockdown cells exhibited increased migration and proliferation, and the significant downregulation of β‑catenin expression. Additionally, ROS1 knockdown sensitized AML cells to the effects of chemotherapeutic ATO. The results of the present study demonstrated that, in leukemic cell lines, ROS1 counteracted the effects of ATO on migration and proliferation, suggesting that ROS1 may be a potential therapeutic target in patients with AML undergoing ATO treatment. The results of the present study provided novel insight into the function of ATO and ROS1 in regulating AML progression.
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Copy and paste a formatted citation
Spandidos Publications style
Li J: Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines. Oncol Lett 15: 9392-9396, 2018.
APA
Li, J. (2018). Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines. Oncology Letters, 15, 9392-9396. https://doi.org/10.3892/ol.2018.8458
MLA
Li, J."Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines". Oncology Letters 15.6 (2018): 9392-9396.
Chicago
Li, J."Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines". Oncology Letters 15, no. 6 (2018): 9392-9396. https://doi.org/10.3892/ol.2018.8458
Copy and paste a formatted citation
x
Spandidos Publications style
Li J: Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines. Oncol Lett 15: 9392-9396, 2018.
APA
Li, J. (2018). Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines. Oncology Letters, 15, 9392-9396. https://doi.org/10.3892/ol.2018.8458
MLA
Li, J."Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines". Oncology Letters 15.6 (2018): 9392-9396.
Chicago
Li, J."Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines". Oncology Letters 15, no. 6 (2018): 9392-9396. https://doi.org/10.3892/ol.2018.8458
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