Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer

  • Authors:
    • Juan An
    • Chuan‑Hao Tang
    • Na Wang
    • Yi Liu
    • Jin Lv
    • Bin Xu
    • Xiao‑Yan Li
    • Wan‑Feng Guo
    • Hong‑Jun Gao
    • Kun He
    • Xiao‑Qing Liu
  • View Affiliations

  • Published online on: April 11, 2018     https://doi.org/10.3892/ol.2018.8460
  • Pages: 9307-9316
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Epidermal growth factor receptor (EGFR) mutation is an important predictor for response to personalized treatments of patients with advanced non‑small‑cell lung cancer (NSCLC). However its usage is limited due to the difficult of obtaining tissue specimens. A novel prediction system using matrix assisted laser desorption ionization‑time of flight mass spectrometry (MALDI‑TOF MS) has been reported to be a perspective tool in European countries to identify patients who are likely to benefit from EGFR tyrosine kinase inhibitor (TKI) treatment. In the present study, MALDI‑TOF MS was used on pretreatment serum samples of patients with advanced non‑small‑cell lung cancer to discriminate the spectra between disease control and disease progression groups in one cohort of Chinese patients. The candidate features for classification were subsequently validated in a blinded fashion in another set of patients. The correlation between plasma EGFR mutation status and the intensities of representative spectra for classification was evaluated. A total of 103 patients that were treated with EGFR‑TKIs were included. It was determined that 8 polypeptides peaks were significant different between the disease control and disease progression group. A total of 6 polypeptides were established in the classification algorithm. The sensitivity of the algorithm to predict treatment responses was 76.2% (16/21) and the specificity was 81.8% (18/22). The accuracy rate of the algorithm was 79.1% (34/43). A total of 3 polypeptides were significantly correlated with EGFR mutations (P=0.04, P=0.03 and P=0.04, respectively). The present study confirmed that MALDI‑TOF MS analysis can be used to predict responses to EGFR‑TKI treatment of the Asian population where the EGFR mutation status differs from the European population. Furthermore, the expression intensities of the three polypeptides in the classification model were associated with EGFR mutation.
View Figures
View References

Related Articles

Journal Cover

June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
An J, Tang CH, Wang N, Liu Y, Lv J, Xu B, Li XY, Guo WF, Gao HJ, He K, He K, et al: Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer. Oncol Lett 15: 9307-9316, 2018
APA
An, J., Tang, C., Wang, N., Liu, Y., Lv, J., Xu, B. ... Liu, X. (2018). Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer. Oncology Letters, 15, 9307-9316. https://doi.org/10.3892/ol.2018.8460
MLA
An, J., Tang, C., Wang, N., Liu, Y., Lv, J., Xu, B., Li, X., Guo, W., Gao, H., He, K., Liu, X."Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer". Oncology Letters 15.6 (2018): 9307-9316.
Chicago
An, J., Tang, C., Wang, N., Liu, Y., Lv, J., Xu, B., Li, X., Guo, W., Gao, H., He, K., Liu, X."Serum peptide expression and treatment responses in patients with advanced non‑small‑cell lung cancer". Oncology Letters 15, no. 6 (2018): 9307-9316. https://doi.org/10.3892/ol.2018.8460