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Article Open Access

Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis

  • Authors:
    • Xuehai Wang
    • Gang Li
    • Qingsong Luo
    • Chongzhi Gan
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8983-8990
    |
    Published online on: April 11, 2018
       https://doi.org/10.3892/ol.2018.8464
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Abstract

To uncover the genes associated with the development of esophageal squamous cell carcinoma (ESCC), an ESCC microarray dataset was used to identify genes differentially expressed between ESCC and normal control tissues. The dataset GSE17351 was downloaded from the Gene Expression Omnibus, containing 5 tumor esophageal mucosa samples and 5 adjacent normal esophageal mucosa samples from 5 male patients with ESCC. The differentially expressed genes (DEGs) were identified using the Linear Models for Microarray Data R package. Then, a co‑expression network was constructed using the Weighted Correlation Network Analysis (WGCNA) package, and co‑expression network modules were obtained with a hierarchical clustering algorithm. Additionally, functional enrichment analyses for DEGs in the top 2 modules with the highest significance were respectively conducted using the WGCNA package and the cluster Profiler package. In total, 487 upregulated and 468 downregulated DEGs were identified. A total of 24 modules were obtained from the co‑expression network, and the top 2 modules with the highest significance, designated as ‘blue4’ and ‘magenta’, were further analyzed. In the module blue4, DEGs were significantly enriched in a number of Gene Ontology terms, including ‘spindle organization’ [e.g., ubiquitin conjugating enzyme E2 C (UBE2C) and SAC3 domain containing 1] and ‘cell cycle process’ [e.g., UBE2C, minichromosome maintenance complex component 6 (MCM6) and cell division cycle 20 (CDC20)]. Furthermore, a number of DEGs (e.g., UBE2C, CDC20 and MCM6) were enriched in the ‘cell cycle’ and ‘ubiquitin mediated proteolysis’ pathways. In the module ‘magenta’, a number of DEGs [e.g., transferrin receptor (TFRC) and TEA domain transcription factor 4 (TEAD4)] were enriched in the primary metabolic process and intracellular membrane‑bounded organelle. Additionally, 308 upregulated genes and 215 downregulated genes were differentially expressed in the same pattern in another dataset, GSE20347, including UBE2C, CDC20, MCM6, TFRC, TEAD4, protein phosphatase 1 regulatory subunit 3C and MAL, T‑cell differentiation protein. These DEGs may function in the development of ESCC.
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1 

Yu VZ, Ko JM, Law S, Wang LD and Lung ML: Abstract 1158: Differential expression and functional impact of the alternatively spliced transcripts of extracellular matrix protein 1 in esophageal squamous cell carcinoma. Cancer Res. 76:11582016. View Article : Google Scholar : PubMed/NCBI

2 

Yan S, Zhou C, Zhang W, Zhang G, Zhao X, Yang S, Wang Y, Lu N, Zhu H and Xu N: β-catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett. 271:85–97. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Zhang H, Lai R, Li E and Xu L: Abstract 3507: STAT3beta suppresses tumorigenesis via modulating the phosphorylation dynamics and transcription activity of STAT3alpha in esophageal squamous cell carcinoma. Cancer Res. 74 19 Suppl:S3507. 2014. View Article : Google Scholar

4 

Yao R, Chen Z, Zhou C, Luo M, Shi X, Li J, Gao Y, Zhou F, Pu J, Sun H and He J: Xerophilusin B induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma cells and does not cause toxicity in nude mice. J Nat Prod. 78:10–16. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Chen YK, Tung CW, Lee JY, Hung YC, Lee CH, Chou SH, Lin HS, Wu MT and Wu IC: Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma. Sci Rep. 6:300572016. View Article : Google Scholar : PubMed/NCBI

6 

Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, et al: Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 31:427–434. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

8 

Hu N, Clifford RJ, Yang HH, Wang C, Goldstein AM, Ding T, Taylor PR and Lee MP: Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma. BMC Genomics. 11:5762010. View Article : Google Scholar : PubMed/NCBI

9 

Li X: An aggregate function method for nonlinear programming. Sci In China (A). 34:1467–1473. 1991.

10 

Altman NS: An introduction to kernel and nearest-neighbor nonparametric regression. American Statist. 46:175–185. 1992. View Article : Google Scholar

11 

Bolstad BM, Irizarry RA, Astrand M and Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19:185–193. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 3:Article32004. View Article : Google Scholar : PubMed/NCBI

13 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Stat Soc (Methodological). 57:289–300. 1995.

14 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Rücker G and Rücker C: On using the adjacency matrix power method for perception of symmetry and for isomorphism testing of highly intricate graphs. J Chem Inf Comput Sci. 31:123–126. 1991. View Article : Google Scholar : PubMed/NCBI

16 

Wang J, Li M, Chen J and Pan Y: A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks. IEEE/ACM Trans Comput Biol Bioinform. 8:607–620. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Nepusz T, Yu H and Paccanaro A: Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods. 9:471–472. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Scheffner M, Nuber U and Huibregtse JM: Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature. 373:81–83. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Jesenberger V and Jentsch S: Deadly encounter: Ubiquitin meets apoptosis. Nat Rev Mol Cell Biol. 3:112–121. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Lin J, Raoof DA, Wang Z, Lin MY, Thomas DG, Greenson JK, Giordano TJ, Orringer MB, Chang AC, Beer DG and Lin L: Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. Neoplasia. 8:1062–1071. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Ieta K, Ojima E, Tanaka F, Nakamura Y, Haraguchi N, Mimori K, Inoue H, Kuwano H and Mori M: Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. Int J Cancer. 121:33–38. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rajkumar T, Sabitha K, Vijayalakshmi N, Shirley S, Bose MV, Gopal G and Selvaluxmy G: Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer. 11:802011. View Article : Google Scholar : PubMed/NCBI

23 

Zhao L, Jiang L, Wang L, He J, Yu H, Sun G, Chen J, Xiu Q and Li B: UbcH10 expression provides a useful tool for the prognosis and treatment of non-small cell lung cancer. J Cancer Res Clin Oncol. 138:1951–1961. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Zhao ZK, Wu WG, Chen L, Dong P, Gu J, Mu JS, Yang JH and Liu YB: Expression of UbcH10 in pancreatic ductal adenocarcinoma and its correlation with prognosis. Tumor Biol. 34:1473–1477. 2013. View Article : Google Scholar

25 

McLean JR, Chaix D, Ohi MD and Gould KL: State of the APC/C: Organization, function, and structure. Crit Rev Biochem Mol Biol. 46:118–136. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Kidokoro T, Tanikawa C, Furukawa Y, Katagiri T, Nakamura Y and Matsuda K: CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene. 27:1562–1571. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Smolders L and Teodoro JG: Targeting the anaphase promoting complex: Common pathways for viral infection and cancer therapy. Expert Opin Ther Targets. 15:767–780. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yamabuki T, Daigo Y, Kato T, Hayama S, Tsunoda T, Miyamoto M, Ito T, Fujita M, Hosokawa M, Kondo S and Nakamura Y: Genome-wide gene expression profile analysis of esophageal squamous cell carcinomas. Int J Oncol. 28:1375–1384. 2006.PubMed/NCBI

29 

Zinovyeva MV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Kostina MB, Sass AV, Filyukova OB, Uspenskaya NY, Sukhikh GT and Sverdlov ED: Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development. Dis Esophagus. 23:260–270. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Jin Z, Mori Y, Yang J, Sato F, Ito T, Cheng Y, Paun B, Hamilton JP, Kan T, Olaru A, et al: Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. Oncogene. 26:6332–6340. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Wada S, Noguchi T, Takeno S and Kawahara K: PIK3CA and TFRC located in 3q are new prognostic factors in esophageal squamous cell carcinoma. Ann Surg Oncol. 13:961–966. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Pobbati AV and Hong W: Emerging roles of TEAD transcription factors and its coactivators in cancers. Cancer Biol Ther. 14:390–398. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T and Inazawa J: YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis. 32:389–398. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Uchikado Y, Inoue H, Haraguchi N, Mimori K, Natsugoe S, Okumura H, Aikou T and Mori M: Gene expression profiling of lymph node metastasis by oligomicroarray analysis using laser microdissection in esophageal squamous cell carcinoma. Int J Oncol. 29:1337–1347. 2006.PubMed/NCBI

35 

Shen Y, Tantai J and Zhao H: Ranking candidate genes of esophageal squamous cell carcinomas based on differentially expressed genes and the topological properties of the co-expression network. Eur J Med Res. 19:522014. View Article : Google Scholar : PubMed/NCBI

36 

Boult J, Roberts K, Brookes MJ, Hughes S, Bury JP, Cross SS, Anderson GJ, Spychal R, Iqbal T and Tselepis C: Overexpression of cellular iron import proteins is associated with malignant progression of esophageal adenocarcinoma. Clin Cancer Res. 14:379–387. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Hu YC, Lam KY, Law S, Wong J and Srivastava G: Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: Overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC. Clin Cancer Res. 7:2213–2221. 2001.PubMed/NCBI

38 

Luo A, Kong J, Hu G, Liew CC, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M and Liu Z: Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene. 23:1291–1299. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Mimori K, Shiraishi T, Mashino K, Sonoda H, Yamashita K, Yoshinaga K, Masuda T, Utsunomiya T, Alonso MA, Inoue H and Mori M: MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway. Oncogene. 22:3463–3471. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Dandara C, Li DP, Walther G and Parker MI: Gene-environment interaction: The role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus. Carcinogenesis. 27:791–797. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Li G, Luo Q and Gan C: Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis. Oncol Lett 15: 8983-8990, 2018.
APA
Wang, X., Li, G., Luo, Q., & Gan, C. (2018). Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis. Oncology Letters, 15, 8983-8990. https://doi.org/10.3892/ol.2018.8464
MLA
Wang, X., Li, G., Luo, Q., Gan, C."Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis". Oncology Letters 15.6 (2018): 8983-8990.
Chicago
Wang, X., Li, G., Luo, Q., Gan, C."Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis". Oncology Letters 15, no. 6 (2018): 8983-8990. https://doi.org/10.3892/ol.2018.8464
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Li G, Luo Q and Gan C: Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis. Oncol Lett 15: 8983-8990, 2018.
APA
Wang, X., Li, G., Luo, Q., & Gan, C. (2018). Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis. Oncology Letters, 15, 8983-8990. https://doi.org/10.3892/ol.2018.8464
MLA
Wang, X., Li, G., Luo, Q., Gan, C."Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis". Oncology Letters 15.6 (2018): 8983-8990.
Chicago
Wang, X., Li, G., Luo, Q., Gan, C."Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis". Oncology Letters 15, no. 6 (2018): 8983-8990. https://doi.org/10.3892/ol.2018.8464
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